NCEH in Partnership with Michigan
The National Center for Environmental Health (NCEH) is part of the
Centers for Disease Control and Prevention (CDC). NCEH’s work
focuses on three program areas: identifying environmental hazards,
measuring exposure to environmental chemicals, and preventing
health effects that result from environmental hazards. NCEH has
approximately 450 employees and a budget for 2004 of approximately
$189 million; its mission is to promote health and quality of life
by preventing or controlling diseases and deaths that result from
interactions between people and their environment.
NCEH and partners in Michigan collaborate on a variety of
environmental health projects throughout the state. In fiscal
years 2000–2004, NCEH awarded more than $4.9 million in
direct funds and services to Michigan for various projects. These
projects include activities related to addressing asthma,
characterizing phthalate exposure among men eating Great Lakes
fish, and preventing childhood lead poisoning. In addition,
Michigan benefits from national-level prevention and response
activities conducted by NCEH or NCEH-funded partners.
Identifying
Environmental Hazards
NCEH identifies, investigates, and
tracks environmental hazards and their effects on people’s health.
Following are examples of such activities that NCEH has conducted
or supported in Michigan.
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Addressing Asthma from a Public
Health Perspective—NCEH is funding the Michigan
Department of Community Health (MDCH) to continue asthma
surveillance activities and to fully implement its asthma plan,
which was developed through a statewide collaborative effort.
Implementation of the statewide comprehensive asthma plan will
reduce the burden of asthma in the home, school, and
occupational environments through disease tracking,
science-based interventions, and statewide partnerships. Funding
began in fiscal year 2000 and ends in fiscal year 2005.
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Investigation of the June 26–July
16, 2002, Events in the New Haven Drinking Water Distribution
System—NCEH reviewed epidemiologic data collected by the
Macomb County Health Department and the operational and
water quality data collected by the Michigan Department of
Environmental Quality (MDEQ) as part of an investigation of
the possible link between water quality issues and human illness
in New Haven after two water main breaks. The study revealed no
relation between the reported illnesses and the changes in water
quality and distribution system integrity. This study was funded
in fiscal year 2003.
Measuring
Exposure to Environmental Chemicals
NCEH measures environmental
chemicals in people to determine how to protect people and improve
their health. Following are examples of such activities that NCEH
conducted or supported in Michigan.
Funding
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Antiterrorism Funding to Increase
State Chemical Laboratory Capacity—In fiscal year 2004, CDC
provided more than $1.8 million to Michigan to help
expand chemical laboratory capacity to prepare for and respond
to chemical-terrorism incidents and other chemical emergencies.
This expansion will allow full participation of
chemical-terrorism response laboratories in the Laboratory
Response Network.
Studies
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Characterizing Phthalate Exposure
Among Men Eating Great Lakes Fish—Phthalates, common
industrial chemicals used in a variety of applications, are
among the most abundant synthetic chemicals in the environment.
They are found in a variety of consumer products and have been
detected in sediment and surface water of the United States,
including the Great Lakes Basin ecosystem. The highest
concentrations have been found in streambed sediment and water
in urban areas. Southeastern Michigan, the region from
which study participants will be recruited, is the most heavily
populated and industrialized area in Michigan.
The purpose of this pilot study, conducted in collaboration with
Michigan State University, is to determine levels of nine
phthalate metabolites in 50 men who eat fish caught in the Great
Lakes. On the basis of questionnaire data, half of the men will
be categorized as people who eat large amounts of fish and half
as people who eat small amounts of fish. The mens’ phthalate
levels will be compared to determine the contribution of fish
consumption to the phthalate body burden. NCEH has received 26
urine samples; analytic results from these samples were returned
to Michigan State University in December 2004.
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Colorectal Neoplasia Screening
with Colonoscopy in Asymptomatic, Average-Risk Women at Regional
Navy/Army Medical Centers (CONCeRN)—The NCEH laboratory, in
collaboration with the National Cancer Institute (NCI) and the
University of Michigan, will analyze folate species,
vitamin B12, vitamin B6, and homocysteine in blood specimens for
the CONCeRN study. Researchers at NCI have enrolled
approximately 1,500 asymptomatic women referred for colorectal
screening to assess the benefits of colonoscopy versus
sigmoidoscopy and to assess potential risk-factor associations
with prevalence of polyps. Epidemiologic studies have shown
associations between folate status and colon cancer. The NCEH
laboratory will use its new state-of-the-art tandem mass
spectrometry method to measure folate species in serum samples
from study participants. The study is ongoing; results are
expected in 2005.
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A Pilot Exposure Investigation:
Dioxin Exposure Among Adults Living in the Tittabawassee River
Flood Plain, Saginaw County—Dioxins are chemical by-products
of industrial and combustion activities, including the
manufacture of chemicals and pesticides. Dioxins are found at
low levels in air, soil, water, and sediment, as well as in
foods such as meat, dairy products, fish, and shellfish. Adverse
health effects have been found in people who have been exposed
to high levels of dioxins. Carcinogenic health effects and
adverse genetic, reproductive, and developmental effects have
been found in animal studies.
During April–December 2000, MDEQ conducted environmental
sampling in the Tittabawassee River basin and found elevated
levels of dioxins throughout the flood plain. This finding
prompted a pilot investigation by MDEQ and MDCH. The pilot study
collected soil and indoor-dust samples from the area and blood
samples from 25 residents. The blood samples will be analyzed to
determine levels of dioxins, furans, and coplanar
polychlorinated biphenyls. The NCEH laboratory has received and
analyzed 20 blood samples in this ongoing investigation.
Services
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Helping State Public Health
Laboratories Respond to Chemical Terrorism—NCEH is working
with Michigan’s public health laboratory to prepare state
laboratory scientists to measure chemical-terrorism agents or
their metabolites in people’s blood or urine. NCEH is
transferring analytic methods for measuring chemical-terrorism
agents (including cyanide-based compounds and other chemicals)
to Michigan. In addition, NCEH instituted a proficiency-testing
program to measure the comparability of the state’s analytic
results with results from the NCEH laboratory.
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Lipid Standardization Program (LSP)―NCEH
provides two lipid research laboratories in Michigan with
accuracy-based standardization support for analytic measurement.
These laboratories are involved in one or more ongoing lipid
metabolism longitudinal studies or clinical trials that
investigate risk factors and complications associated with
cardiovascular disease. The LSP, supported by NCEH’s Lipid
Reference Laboratory, provides quarterly analytic performance
challenges and statistical assessment reports that allow program
participants to monitor performance over time and thus ensure
the accuracy and comparability of study results and findings.
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Newborn Screening Quality
Assurance Program―NCEH provides proficiency-testing services
and dried-blood-spot quality-control materials to monitor and
help assure the quality of screening program operations for
newborns in Michigan. Michigan screens newborns for 12
diseases and conditions. The importance of accurate screening
tests for genetic metabolic diseases cannot be overestimated.
Testing of blood spots collected from newborns is mandated by
law in almost every state to promote early intervention that can
prevent mental retardation, severe illness, and premature death.
Preventing
Health Effects That Result from Environmental Hazards
NCEH promotes safe environmental
public health practices to minimize exposure to environmental
hazards and prevent adverse health effects. Following are examples
of such activities that NCEH conducted or supported in Michigan.
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Childhood Lead Poisoning
Prevention Program—The Michigan Childhood Lead Poisoning
Prevention Program (MI CLPPP) has received NCEH funding
since 1992. NCEH has also funded the city of Detroit (Detroit
CLPPP) under a separate cooperative agreement since 1992. In
2001, both programs combined screened 83,867 children for lead
poisoning; 5,109 children under 6 years of age had elevated
blood lead levels.
The Detroit CLPPP and MI CLPPP are using NCEH funds to implement
plans to eliminate childhood lead poisoning elimination plan for
Detroit the rest of the state, respectively, and to increase
their targeted screening and primary prevention activities. The
programs are also using NCEH funds to maintain the existing
surveillance system, increase protective policy, and build
strategic partnerships.
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Building Communities of
Excellence Through Environmental Health Capacity-Building—In
fiscal year 2004, NCEH established a 3-year cooperative
agreement with the Detroit Department of Health and Wellness
Promotion to implement the environmental health services and
capacity-building components of a comprehensive asthma program
for the city of Detroit. The ultimate goal is to reduce
asthma exacerbations due to environmental triggers. Successful
implementation of the program is expected to reduce the number
of episodes that result in emergency department visits and
hospitalizations, the number of missed school days and resulting
adult workdays, and the use of quick-relief medications.
Activities will include conducting general and topic-specific
workshops in the community and schools on asthma triggers (e.g.,
integrated pest management, mold), conducting home assessment
and home cleaning interventions, and promoting indoor air
quality programs in day-care centers and schools. Activities
will also include educating healthcare personnel and public
housing authorities about maintenance issues that can help
eliminate asthma triggers, conducting train-the-trainer
programs, educating communities about sources of outdoor
triggers attributed to various industries, and developing a
surveillance program.
Resources
NCEH develops materials that public
health professionals, medical-care providers, emergency
responders, decision makers, and the public can use to identify
and track environmental hazards that threaten human health and to
prevent or mitigate exposure to those hazards. NCEH’s resources
cover a range of environmental public health issues. These issues
include air pollution and respiratory health (e.g., asthma, carbon
monoxide poisoning, and mold exposure), biomonitoring to determine
whether selected chemicals in the environment get into people and
to what degree, childhood lead poisoning, emergency preparedness
for and response to chemicals and radiation, environmental health
services, environmental public health tracking, international
emergency and refugee health, laboratory sciences as applied to
environmental health, radiation studies, safe disposal of chemical
weapons, specific health studies, vessel sanitation, and veterans’
health.
For more information about NCEH programs, activities, and
publications as well as other resources, contact the NCEH Health
Line toll-free at 1-888-232-6789, e-mail
NCEHinfo@cdc.gov, or visit
the NCEH Web site at
www.cdc.gov/nceh.
March 2005
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