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Team of professionalsEarly detection of iron overload requires an understanding of the complex relationships between prevalence of iron overload, HFE gene mutations and penetrance of the disease.

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"An important challenge for genomics and public health in the next decade is to develop the road map for integrating genetics into disease prevention and health promotion programs. Ultimately people die from diseases and not from genes. We need information, information, and more information! We need to collect, analyze, and disseminate population-level information on the prevalence of gene variants, disease burden, and gene-environment interaction. We also need to evaluate genetic tests and the utility of genetic information. The ultimate challenge is to determine the benefits of using genetic information to target interventions that improve health and prevent disease. The obvious issues are why, how, and when we should change our traditional public health-oriented interventions to become more targeted on the basis of individual differential susceptibilities to disease."

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Muin J. Khoury, MD, PhD
Centers for Disease Control and Prevention
Director, Office of Genomics and Disease Prevention

Content in this module includes:

  • Prevalence of iron overload and HFE gene mutations.
  • Patients at risk for iron overload, hemochromatosis, and hereditary hemochromatosis.
  • Penetrance of HFE gene mutations.
  • Population screening.
  • Understanding iron overload in the context of the patient’s family and medical history.
  • Evaluating iron overload in the context of the patient’s medical and family history.

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