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Economic Costs of Deep Vein Thrombosis

Incidence-based cost estimates require population-based incidence data. A critique of Mahan et al.

Scott D. Grosse

The following paper was published in modified form by Schattauer in Thrombosis and Haemostasis. doi:10.1160/TH11-09-0666
Thromb Haemost 2012; 107:192–193

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PublicationsRecent Articles

* These CDC scientific articles are listed in order of date published, from present to 2006.

Obesity-related Coagulation Changes in Pregnancy
Smrtka MP, Thames B, Beckman M, Rajgor D, Gandhi M,
James AH
Thrombosis Research; February 2012; 129(2):204-6.
[Read Summary]

 

Incidence-based Cost Estimates Require Population-based Incidence Data: A Critique of Mahan et al.
Thrombosis and Hemostasis; January 2012; 107(1):192–193.
Grosse SD
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Developing Surveillance Activities for Deep Vein Thrombosis and Pulmonary Embolism
Beckman MG, Grosse SD, Kenney KM, Grant AM, Atrash HK
American Journal of Preventive Medicine; December 2011; 41(6S4): S428–S434.
[Read Summary]

 

Health Care Expenditures Associated with Venous Thromboembolism Among Children
Thrombosis Research; published online, August 25, 2011.
Boulet SL, Amendah D, Grosse SD, Hooper WC.
[Read Summary]

 

The Impact of Co-morbid Conditions on Family History of Venous Thromboembolism in Whites and Blacks
Mili FD, Hooper WC, Lally C, Austin H
Thrombosis Research; April 2011; 127:309-316.
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New Gene Variants Associated with Venous Thrombosis: A Replication Study in White and Black Americans
Austin H, De Staercke C, Lally C, Bezemer ID, Rosendaal FR, Hooper WC
Journal of Thrombosis and Haemostasis; 2011; 9(3):489-95
[Read Summary]

 

Prevalence of Venous Thromboembolism Among Privately Insured US Adults
Boulet SL, Grosse SD, Hooper WC, Beckman MG, Atrash HK
Archives of Internal Medicine; October 2010; 170(19):1774–1775
[Read Summary]

 

Comparison of Characteristics from White- and Black-Americans with Venous Thromboembolism: A Cross-Sectional Study
American Journal of Hematology, July 2010; 85(7):467-71.
Heit J, Beckman M, Bockenstedt P, et al.
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Venous Thromboembolism: A Public Health Problem in Need of a Public Health Response
American Journal of Preventive Medicine; April 2010, Volume 38, Issue 4, Supplement 1, pp. S495-S501.
Beckman M, Hooper WC, Critchley S, Ortel TL
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Venous Thromboembolism in African-Americans: A Literature-based Commentary
Thrombosis Research; January 2010; Volume 125, Issue 1, pp. 12-8.
Hooper WC.
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Hormonal Contraception, Sickle Cell Trait, and Risk for Venous Thromboembolism among African American Women
American Journal of Obstetrics and Gynecology; June 2009, Volume 200, Issue 6, 620.e1-3.
Austin H, Lally C, Benson JM, Whitsett C, Hooper WC, Key NS.
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Fibrinogen Gamma Gene 3'-end Polymorphisms and Risk of Venous Thromboembolism in the African-American and Caucasian Population
Journal of Thrombosis and Haemostasis; June 2009, Volume 101, Issue 6, pp. 1078-84.
de Willige SU, Pyle ME, Vos, HL, et al.
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Public Health Research Activities in Venous Thromboembolism
Arteriosclerosis, Thrombosis, and Vascular Biology; 2008, Volume 28 p. 394-5.
Beckman M, Critchley S, Hooper WC, Grant A, Kulkarni R.
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Sickle Cell Trait and the Risk of Venous Thromboembolism among Blacks
Blood; August 1, 2007, Volume 110, Issue 3, pp. 908-12.
Austin H, Key NS, Benson JM, Lally C, Dowling NF, Whitsett C, Hooper WC.
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The Prevalence of the Prothrombin Gene Variant C20209T in African-Americans and Caucasians and Lack of Association with Venous Thromboembolism
Thrombosis Research; 2006, Volume 118, Issue 6, pp. 767-8.
Hooper WC, Roberts S, Dowling N, Austin H, Lally C, Whitsett C.
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A chromosome contains a single, long piece of DNA with many different genes. Every human cell contains 23 pairs of chromosomes. There are 22 pairs of numbered chromosomes, called autosomes, and one pair of sex chromosomes, which can be XX or XY. Each pair contains two chromosomes, one from each parent, which means that children get half of their chromosomes from their mother and half from their father.


A gene is a part of DNA that carries the information needed to make a protein. People inherit one copy of each gene from their mother and one copy from their father. The genes that a person inherits from his or her parents can determine many things. For example, genes affect what a person will look like and whether the person might have certain diseases.


DNA is made up of two strands that wind around each other and looks like a twisting ladder. A DNA strand is made up of four different “bases” arranged in different orders. These bases are T (thymine), A (adenine), C (cytosine), and G (guanine). DNA is “read” by the order of the bases, that is by the order of the Ts, Cs, Gs, and As. The specific order, or sequence, of these bases determines the exact information carried in each gene (for example, instructions for making a specific protein). DNA has the same structure in every gene and in almost all living things.


A mutation is a change in a DNA sequence. DNA mutations in a gene can change what protein is made. Mutations present in the eggs and sperm (germline mutations) can be passed on from parent to child, while mutations that occur in body cells (somatic mutations) cannot be inherited.


A protein is made up of building blocks called amino acids. The main role of DNA is to act as the instructions for making proteins. It is actually proteins that make up most of the structures in our bodies and perform most of life’s functions. For example, proteins make up hair and skin. Proteins in our eyes change shape in response to light so we can see. Proteins in our bodies break down food. Proteins are made in cells and are the major parts of cells, which are the vital working units of all living things.


Environmental factors can include exposures related to where we live as well as behaviors such as smoking and exercise and cultural factors such as foods that we eat.

 
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