Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home

Table 6: Examples of Treatment Regimens for Clinical Vitamin B12 Deficiency.

Due to Initial Cyanocobalamin Maintenance Cyanocobalamin
Pernicious anemia

Varies, not limited to:

  • 1 mg intramuscularly (IM) or subcutaneously (SQ) every (q) week X 8

OR

  • 1 mg IM or SQ X 7 in one month
  • 1 mg IM or sq q month for life

OR

  • 1 mg - 2 mg orally (PO) everyday (QD) for life

Other foodbound B12 malabsorption problems

Varies, not limited to:

  • 1 mg IM or SQ q week x 8

OR

  • 1 mg IM or SQ x 7 in one month

OR

  • 1 mg-2mg PO QD
  • 1 mg IM or SQ q month possibly for life

OR

  • 1 mg PO QD possibly for life
Rarer malabsorption problems (tape worms, bacterial overgrowth)
  • Treat underlying condition

AND

Cyanocobalamin varies, not limited to:

  • 1 mg IM or SQ q week x 8

OR

  • 1 mg IM or SQ x 7 in 1 month
  • 1 mg IM or SQ q month

OR

  • 1 mg PO QD

Treating underlying condition might resolve B12 deficiency. If cyanocobalamin is d/c'd, follow up with regular assessment of metabolites

Approaches suggested by Stabler and Allen and Carmel

Return to previous page

 

 
Contact Us:
  • Centers for Disease Control and Prevention

    National Center on Birth Defects and Developmental Disabilities

    Division of Birth Defects and Developmental Disabilities

    1600 Clifton Road
    MS E-87
    Atlanta, GA 30333
  • 800-CDC-INFO
    (800-232-4636)
    TTY: (888) 232-6348
    New Hours of Operation
    8am-8pm ET/Monday-Friday
    Closed Holidays
  • cdcinfo@cdc.gov
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - cdcinfo@cdc.gov
A-Z Index
  1. A
  2. B
  3. C
  4. D
  5. E
  6. F
  7. G
  8. H
  9. I
  10. J
  11. K
  12. L
  13. M
  14. N
  15. O
  16. P
  17. Q
  18. R
  19. S
  20. T
  21. U
  22. V
  23. W
  24. X
  25. Y
  26. Z
  27. #