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Table 1: Neurologic and Psychiatric Symptoms of Vitamin B12 Deficiency and Parkinson Disease (PD)

AbnormalitiesVitamin B12 DeficiencyPD
Autonomic

Impotence, urinary or fecal incontinence

++
Orthostatic hypotension
++
Cerebral
Dementia, memory loss, cognitive impairment
++*
Depression
++
Psychosis
++*
Myelopathic
Subacute combined degeneration
+-
Ataxia
+-
Spasticity
+-
Lehrmitte sign (electric-shock-like sensations in the spine)
++
Abnormal Gait
Spastic
+-
Shuffling
-+
Constitutional
Fatigue
++

*Seen in PD or resulting from dopaminergic PD treatment, or both

†Note gait abnormalities do not always appear "typical" of textbook descriptions

Table developed by Marian Evatt, MD

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