Case Definition for Acute Idiopathic Pulmonary Hemorrhage in Infants

Table 1. Analytic Classification Scheme for Acute Idiopathic Pulmonary Hemorrhage in Infants
Criterion A Criterion B Criterion C
Case Status Categories Abrupt onset of bleeding from lower airway Intubated. Acute respiratory distress or respiratory failure CXR/CT chest: Diffuse, bilateral pulmonary infiltrates
Clinically Confirmed-1 Criterion A met Criterion B met Criterion C met
Clinically Confirmed-2 Criterion A met Criterion B met Unilateral pulmonary infiltrates
Probable-1 Criterion A met In PICU with severe respiratory distress but not intubated Criterion C met
Probable-2 a. Criterion A met Not in severe respiratory distress Criterion C met
b. Criterion A met In PICU with severe respiratory distress but not intubated Unilateral pulmonary infiltrates
Probable-3 a. Infant died, bleeding based on autopsy or post mortem findings Would have been intubated in the opinion of the clinician Criterion C met
b. Infant died, bleeding based on autopsy or post mortem findings Would have been intubated in the opinion of the clinician Unilateral pulmonary infiltrates
c. Criterion A met Criterion B met No pulmonary infiltrates
Probable-4 a. Criterion A met In PICU with severe respiratory distress but not intubated No pulmonary infiltrates
b. Criterion A met Not in severe respiratory distress Unilateral pulmonary infiltrates
Probable-5 a. Infant died, bleeding based on autopsy or post mortem findings Not in severe respiratory distress Unilateral pulmonary infiltrates
b. Criterion A met Not in severe respiratory distress No pulmonary infiltrates
Suspected a. Infant died, bleeding based on autopsy or post mortem findings Would have been intubated in the opinion of the clinician No pulmonary infiltrates, or no CXR/CT
b. Infant died, bleeding based on autopsy or post mortem findings Not in severe respiratory distress No pulmonary infiltrates, or no CXR/CT
Notes:
  1. All categories assume a previously healthy infant <1 year & >32 weeks gestation.
  2. 1 to 5 represents categories with decreasing levels of certainty: 1=highly probable, 5=least probable.
  3. a, b, & c represent approximately equivalent levels within each category based on variations of criteria A, B & C.
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