Skip Navigation LinksSkip Navigation Links
Centers for Disease Control and Prevention
Safer Healthier People
Blue White
Blue White
bottom curve
CDC Home Search Health Topics A-Z spacer spacer
Blue curve MMWR spacer

Notice to Readers FDA Approval of Change in Pediatric Formulation for Recombivax HB{Registered}

Effective August 27, 1998, the Merck Vaccine Division (Merck & Co., Inc., West Point, Pennsylvania) discontinued distribution and production of the 2.5-ug dose of Recombivax HB{Registered} * pediatric hepatitis B vaccine, which was licensed by the Food and Drug Administration for infants of hepatitis B surface antigen (HBsAg)-negative mothers and children aged less than or equal to 10 years. The 2.5-ug dose was replaced with a 5.0-ug dose previously used for vaccination of adolescents and infants of HBsAg-positive mothers. To simplify the vaccination schedule for infants and children, the Advisory Committee on Immunization Practices recommends use of the 5.0-ug dose for all children and adolescents aged 0-19 years. Either the 2.5-ug dose or the 5.0-ug dose may be used to complete any vaccine series already started for children aged less than or equal to 10 years, regardless of the initiating dose of vaccine. Children who have completed the hepatitis B vaccination series with the 2.5-ug dose do not need to be revaccinated.

  • Use of trade names and commercial sources is for identification only and does not imply endorsement by CDC or the U.S. Department of Health and Human Services.

Disclaimer   All MMWR HTML versions of articles are electronic conversions from ASCII text into HTML. This conversion may have resulted in character translation or format errors in the HTML version. Users should not rely on this HTML document, but are referred to the electronic PDF version and/or the original MMWR paper copy for the official text, figures, and tables. An original paper copy of this issue can be obtained from the Superintendent of Documents, U.S. Government Printing Office (GPO), Washington, DC 20402-9371; telephone: (202) 512-1800. Contact GPO for current prices.

**Questions or messages regarding errors in formatting should be addressed to

Page converted: 01/21/99


Safer, Healthier People

Morbidity and Mortality Weekly Report
Centers for Disease Control and Prevention
1600 Clifton Rd, MailStop E-90, Atlanta, GA 30333, U.S.A


Department of Health
and Human Services

This page last reviewed 5/2/01