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Epidemiologic Notes and Reports Antibody Response to A/Taiwan/ 86 (H1N1) Virus in Young Adults Receiving Supplemental Monovalent A/ Taiwan/86 Influenza Vaccine Following Trivalent Influenza Vaccine

In accordance with recent recommendations (1), monovalent A/Taiwan/86 (H1N1) influenza vaccine was given to U.S. Air Force recruits who had been vaccinated 2 to 3 months previously with the 1986/87 trivalent influenza vaccine. Thirty-four recruits volunteered sera for antibody studies of immune response. At the time the A/Taiwan/86 vaccine was administered, 100% of the recruits had serum hemagglutination-inhibition (HI) antibody titers of greater than or equal to 32 to the A/Chile/83 (H1N1) virus included in the trivalent vaccine, but only 45% had such titers to the A/Taiwan/86 strain. Following immunization with the supplemental monovalent vaccine, the proportion of recruits with HI antibody titers of greater than or equal to 32 against A/Taiwan/86 virus increased to 100%, and 92% had HI titers greater than or equal to 128 (Table 1). Reported by G Meiklejohn, MD, Patricia Graves, School of Medicine, Univ of Colorado Health Sciences Center, Denver, Col G Hutchison, Lowry Air Force Base, Colorado; Lt Col M Evans, MD, Lackland Air Force Base, Texas; Influenza Br, Div of Viral Diseases, Center for Infectious Diseases, CDC.

Editorial Note

Editorial Note: The above findings are consistent with previous reports (2,3) that the A/Chile/83 component of the 1986/87 trivalent vaccine may provide inadequate protection against the A/Taiwan/86 virus; protection may be boosted by use of the monovalent A/Taiwan/86 vaccine as recommended (1). Because all recently reported outbreaks of influenza A/Taiwan/86-like virus, where laboratory confirmation has been obtained, have occurred in children or young adults, it is particularly important that high-risk individuals in these age groups be given priority for vaccination with the supplemental A/Taiwan/86 vaccine. (See "Update of Influenza Activity, Availability of Influenza Vaccines, and Recommendations and Precautions for the Use of Amantadine", pp. 805-807.)


  1. ACIP. Monovalent influenza A(H1N1) vaccine, 1986-87. MMWR 1986;35:517-21.

  2. CDC. Antigenic variation of recent influenza A(H1N1) viruses. MMWR 1986;35:510-2.

  3. CDC. Influenza activity in civilian and military populations and key points for use of influenza vaccines. MMWR 1986;35:729-31.

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