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March 28, 2003
ACIP Summary Statement
The ACIP held an emergency meeting by conference call on Friday, March 28, 2003, to make recommendations to CDC regarding cases of cardiac adverse events that have been reported following smallpox vaccination. A list of participants appears at the bottom of this page.
The specific questions that the Committee was asked to address were:
Ten cases of myopericarditis have been reported among several hundred thousand members of the military, and two such cases (one of myocarditis and one of pericarditis) have been reported among civilian vaccinees. Additionally, CDC has received reports of 5 patients with cardiac ischemic events following smallpox vaccination, including 3 patients with myocardial infarctions and two patients with angina. Two of the persons with heart attacks, have died. These cases were reported this week in the MMWR.
Options considered by the Committee included:
The Committee recommended that CDC exclude persons with known underlying heart disease and persons with 3 or more major cardiac risk factors (option 2). Draft screening questions were presented to the Committee and will be further reviewed with cardiologists and finalized early next week. The Committee approved CDCs proposed research and did not recommend that special medical follow-up was needed for persons with cardiovascular risk factors who had been vaccinated.
However, persons who have received the smallpox vaccine should see a health care provider right away if they develop shortness of breath, chest pain or other symptoms of cardiac disease. Persons who have been diagnosed by a physician as having heart disease and have questions, should contact their heart disease specialist or regular health care provider. All people with heart disease or risk factors should receive the routine care recommended for persons with these conditions.
The ACIP is an advisory committee of the Centers for Disease Control and Prevention.
MODLIN, John F., M.D.
SNIDER, Dixie E., Jr., M.D.
BIRKHEAD, Guthrie S., M.D.
BONOW, Robert (Cardiologist)
BROOKS, Dennis A., M.D., M.P.H.
BRAINWALD, Eugene (retired) (Cardiologist)
FOSTER, Valentine (Cardiologist)
GARDENER, Pierce, M.D.
GUERRA, Fernando A., M.D.,
HANSON, I. Celine, M.D.
MENSAH, George (Cardiologist)
LEVIN, Myron J., M.D.
NEFF, John M.D. (SP Vac. Safety Working Gp.)
OFFIT, Paul A., M.D.
RENNELS, Margaret B., M.D.
SALAMONE, John E.
SIEGEL, Jane D., M.D. (SP Vaccine Safety Working group (SVSWG))
SMITH, Natalie J., M.D., M.P.H.
TOMPKINS, Lucy S., M.D., Ph.D.
Other Who Spoke
GRABENSTEIN, John (DOD)
For more information on smallpox, visit http://www.bt.cdc.gov/agent/smallpox/.
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This page last updated March 28, 2003
Department of Health and Human Services