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MMWR
Synopsis for August 31, 2001

MMWR articles are embargoed until 4 p.m., EST, Thursdays.

  1. Update: Fatal and Severe Liver Injuries Associated With Rifampin and Pyrazinamide for Latent Tuberculosis Infection, and Revisions in American Thoracic Society/CDC Recommendations — United States, 2001
  2. Impact of Targeted, School-Based Dental Sealant Programs in Reducing Racial and Economic Disparities in Sealant Prevalence Among Schoolchildren — Ohio, 1998–1999
  3. Progress Toward Poliomyelitis Eradication — South-East Asia, 2000–June 2001

Synopsis for August 31, 2001

Update: Fatal and Severe Liver Injuries Associated With Rifampin and Pyrazinamide for Latent Tuberculosis Infection, and Revisions in American Thoracic Society/CDC Recommendations — United States, 2001

Guidelines for the treatment of latent TB infection have been revised.

 
PRESS CONTACT:
Office of Communications

CDC, National Center for HIV, STD and TB Prevention
(404) 639–8895
 

CDC has investigated reports of 21 patients who were hospitalized because of severe liver injury associated with a two-month treatment regimen of rifampin and pyrazinamide (RIF-PZA) for latent TB infection (LTBI). Sixteen of the patients recovered and five died. As a result of these investigations, CDC and the American Thoracic Society are issuing revised treatment guidelines for LTBI to strengthen the level of patient counseling and monitoring recommended for LTBI treatment regimens and to limit the circumstances in which the combination of RIF-PZA is prescribed. Providers are asked to use RIF-PZA with caution, especially in those currently taking other medications that have been associated with liver injury, and those with alcoholism even if alcohol usage is discontinued during treatment.

 

Impact of Targeted, School-Based Dental Sealant Programs in Reducing Racial and Economic Disparities in Sealant Prevalence Among Schoolchildren — Ohio, 1998–1999

Providing sealant programs in eligible schools could help reduce or eliminate racial and income disparities among children at high-risk for dental decay.

 
PRESS CONTACT:
William Kohn, D.D.S.

CDC, National Center for Chronic Disease Prevention & Health Promotion
(770) 488–6071
 

This report summarizes the results of a survey of Ohio public elementary school students, comparing the prevalence of dental sealants in third-graders attending schools with a school-based sealants program (69 schools) to schools that did not have a program (266 schools). Dental sealants are a plastic coating applied to the chewing surfaces of teeth to prevent dental decay. Twelve dental professionals conducted a clinical screening on 11,191 third graders (57.5% of those eligible). Among the principal findings are: (1) students attending schools with dental sealant programs were two to three times more likely to have sealants applied as those students from non-program schools; (2) among the targeted program schools, all racial and income groups had achieved or exceeded the Healthy People 2010 objective.

 

Progress Toward Poliomyelitis Eradication — South-East Asia, 2000–June 2001

Poliomyelitis eradication is progressing rapidly in South-East Asia, with Northern India remaining the last area of intense wild virus circulation.

 
PRESS CONTACT:
Patrick Zuber, M.D., M.P.H.

CDC, National Immunization Program
(404) 639–8906
 

The South-East Asia Region of the World Health Organization is on the verge of eradicating wild polioviruses. While 272 poliomyelitis cases with wild virus were still reported from 4 countries during the year 2000, only 31 cases were found in 4 Northern Indian states during the first 6 months of 2001. This progress occurs in the face of greatly improved surveillance since 2000. Intense vaccination activities, combining up to 6 annual rounds of intensified poliovirus vaccination in areas at highest risk, have allowed this remarkable progress. Interruption of wild poliovirus transmission could occur within 6 to 12 months if these efforts can be sustained.

 


 

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