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Additional Resources for Lyme Disease

General

Brochure: Lyme disease: What you need to know [PDF - 12 pages]

Halperin JJ, Baker P, Wormser GP. Common misconceptions about Lyme disease. Am J Med 2013;126(3):264.

How to evaluate health information on the internet

Hu LT. Lyme Disease. Ann Intern Med 2012;157:ITC2-1.

Stanek G, Wormser GP, Gray J, Strle F. Lyme borreliosis. Lancet 2012;379(9814):461-73.

Lyme Carditis

Forrester JD, Mead P. Third-degree heart block associated with lyme carditis: Review of published cases.  Clin Infect Dis 2014 May 30. pii: ciu411.

Three Sudden Cardiac Deaths Associated with Lyme Carditis — United States, November 2012–July 2013. MMWR Dec 13;62(49):993-6.

Pediatrics

American Academy of Pediatrics. Lyme disease (Lyme borreliosis, Borrelia burgdorferi infection). In: Pickering LK, Red Book: 2012

Feder HM Jr. Lyme disease in children. Infect Dis Clin North Am 2008 Jun;22(2):315-26, vii.

Pregnancy

Walsh CA, Mayer EW, Baxi LV. Treatment of Lyme disease. Lyme disease in pregnancy: case report and review of the literature. Obstet Gynecol Surv 2007 Jan;62(1):41-50.

Prevention Information

Prevention of Lyme disease. American Academy of Pediatrics. Committee on Infectious Diseases. Pediatrics 2000 Jan;105(1 Pt 1):142-7.

Hayes EB, Piesman J. How can we prevent Lyme disease? N Engl J Med 2003; 348:2424-2430 (Access granted courtesy of New England Journal of Medicine.)

Tick management handbook: An integrated guide for homeowners, pest control operators, and public health officials for the prevention of tick-associated diseases [PDF - 84 pages]. From Connecticut Agricultural Experiment Station, New Haven CT.

Insect repellents: Use and effectiveness (EPA)

Hazards to outdoor workers: Lyme disease. National Institute for Occupational Safety and Health (NIOSH)

Research

ClinicalTrials.gov Studies of Lyme disease / “Borrelia Infections”

TickNET, a collaborative public health effort established by CDC in 2007, fosters coordinated surveillance, research, education, and prevention of tickborne diseases.

Testing

Aguero-Rosenfeld ME, Wang G, Schwartz I, Wormser GP. Diagnosis of Lyme borreliosis. Clin Microbiol Rev 2005 Jul;18(3):484-509.

Branda JA, Strle F, Strle K, Sikand N, Ferraro MJ, Steere AC. Performance of United States serologic assays in the diagnosis of Lyme borreliosis acquired in Europe. Clin Infect Dis 2013 Aug;57(3):333-40.

Concerns regarding a new culture method for Borrelia burgdorferi not approved for the diagnosis of Lyme disease. MMWR 2014;63:333

Hinckley AF, Connally NP, Meek JI, Johnson BJ, Kemperman MM, Feldman KA, White JL, Mead PS. Lyme disease testing by large commercial laboratories in the United States. Clin Infect Dis 2014 May 30. pii: ciu397.

Johnson BJ, Pilgard MA, Russell TM. Assessment of new culture method for detection of Borrelia species from serum of Lyme disease patients. J Clin Microbiol 2014;52:721–4.

Notice to readers: caution regarding testing for Lyme disease. MMWR, CDC Surveillance Summary 2005;54:125.

Johnson, B.J. "Chapter 4: Laboratory diagnostic testing for Borrelia burgdorferi infection" in Lyme disease: An Evidence-based Approach, J.J. Halperin, Ed. (CAB International, 2011). Complete Article Reproduced with Permission [PDF - 16 pages].

Recommendations for test performance and interpretation from the second national conference on serologic diagnosis of Lyme disease. MMWR 1995;44:590–591.

Transmission and Ecology

Steere AC, Coburn J, Glickstein L. The emergence of Lyme disease. J Clin Invest 2004 Apr 15; 113(8): 1093-1101.

Swanson SJ, Neitzel D, Reed KD, Belongia EA. Coinfections acquired from Ixodes ticks. Clin Microbiol Rev 2006 Oct;19(4):708-27.

Treatment

Practice guidelines for the treatment of Lyme disease. Infectious Diseases Society of America. Clin Infect Dis 2006;43:1089-1134.

Klempner MS, Hu LT, Evans J, Schmid CH, Johnson GM, Trevino RP, Norton D, Levy L, Wall D, McCall J, Kosinski M, Weinstein A. Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. New Eng. J. Med. 345:85-92, 2001.

Krupp LB, Hyman LG, Grimson R, Coyle PK, Melville P, Ahnn S, Dattwyler R, Chandler B. Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial. Neurology 2003 Jun 24;60(12):1923-30.

Fallon BA, Keilp JG, Corbera KM, Petkova E, Britton CB, Dwyer E, Slavov I, Cheng J, Dobkin J, Nelson DR, Sackeim HA. A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy. Neurology 2008 Mar 25;70(13):992-1003.

Schoen RT. A case revealing the natural history of untreated Lyme disease. Nat Rev Rheumatol 2011 Mar;7(3):179-84.

Lyme Disease Vaccine

Livey I, O'Rourke M, Traweger A, Savidis-Dacho H, Crowe BA, Barrett PN, Yang X, Dunn JJ, Luft BJ. A new approach to a Lyme disease vaccine. Clin Infect Dis 2011 Feb;52 Suppl 3:s266-70.

Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis 2011 Feb;52 Suppl 3:s247-52.

Wressnigg N, et al. Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial. Lancet Infect Dis 2013 Aug;13(8):680-9.

Search the Biomedical Literature

PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.

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