Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home

General Refugee Health Guidelines

Bhutanese refugee children sitting on boxes and playing

Bhutanese refugee children sitting on boxes and playing


On average, close to 60,000 refugees relocate to the United States annually. 1 They come from diverse regions of the world and bring with them health risks and diseases common to all refugee populations as well as some that may be unique to specific populations. The purpose of this document is to describe general and optional testing components that do not fall into the specific disease categories of these guidelines. These guidelines are based upon principles of best practices, with references to primary published reports when available.

This document differs from others in the guidelines, which recommend screening for specific disorders. The guidelines in this document include testing for abnormalities or clinical conditions that are not specific disorders but are suggestive of underlying disorders. The tests in this document may indicate either acute or chronic disorders and generally indicate the need for further testing and evaluation to identify the condition causing the abnormality. Testing for chronic health conditions is important, since these conditions are common in newly arriving refugees, both children and adults. 2 Since refugee populations are diverse and are predisposed to diseases that may differ from those found in the U.S. population, the differential diagnosis and initial evaluation of abnormalities are discussed to assist the clinician.

General and Optional Tests

Many disorders may be detected by using general, nonspecific testing modalities. Preventive screening, counseling, and testing, which are routinely used in the general U.S. population, may identify people with or at risk for chronic disorders. In addition, the process of migration and adaptation to a new lifestyle in the United States generally predisposes refugees to disorders, such as hyperlipidemia and cardiovascular diseases, not commonly encountered in refugee populations on arrival. This document discusses guidelines (Table 1) for conditions commonly detected on arrival, including hematologic disorders, renal disease, and metabolic disorders of adults and children. In addition, medical screening routinely recommended in the United States for such conditions as cardiovascular diseases and cancers should be performed. This may be done at the new-arrival medical evaluation, or arrangements should be made for timely follow-up with primary care for testing.

Table 1. General and Optional Testing for Newly Arrived Refugees
Recommended for All Refugees
  • Complete blood count with a white blood cell differential and platelets
  • Urinalysis (if old enough to provide a clean-catch urine specimen)
  • Infant metabolic screening in newborn infants, according to state guidelines
Recommended for Specific Populations
  • Serum lipid profile
  • Cancer screening (See Table 4 for population-specific information)
  • Uric acid (for Hmong refugees)
  • Serum chemistries and glucose


1. Complete Blood Count with Red Blood Cell Indices, White Blood Cell Differential, and Platelet Count

Who Should Be Tested

Newly arrived refugees of all ages and ethnicities

Potential Disorders Detected

A. Anemia

Anemia is a common finding in refugees of all ages and ethnicities. The prevalence of anemia in selected groups of newly arrived populations has ranged from 19% among African refugees resettling in Australia to 37% among Southeast Asian refugees resettling in the United States. 2 3 Anemia was identified in 12% of 1,247 refugee children in Massachusetts, with a rate of 29% among children under 2 years. 4 In addition, a study in Maine found 20% of 127 refugee children were anemic at the time of their new-arrival medical evalution. 5

Anemia may result from a wide range of disease processes. Common causes of anemia in refugee populations include iron deficiency, inherited hematologic abnormalities (e.g., thalassemias, hemoglobinopathies, enzyme defects), and infectious diseases (e.g., malaria, intestinal parasitosis). The ultimate cause is often multifactorial;6 therefore, the clinician needs to consider multiple conditions whenever anemia is detected. The complete evaluation of anemia in refugees is beyond this scope of this document, but common causes and initial testing are discussed below and summarized in Table 2.

Iron-Deficiency Anemia (IDA)

IDA, probably the most common cause of anemia in immigrant populations, is usually manifested as a microcytic anemia (Table 2). The groups most commonly affected are children and women;7 however, refugees of both sexes and all age groups are at risk. Although IDA is frequently multifactorial, it is primarily caused by deficient dietary iron. Chronic blood loss, which frequently adds to iron deficiency, is commonly caused by infection with intestinal parasites, particularly hookworm. Helicobacter pylori infections may lead to gastrointestinal blood loss through ulcer formation. If iron deficiency has not been longstanding or severe, frank anemia may not result, but changes in red blood cell morphology, including microcytosis (low mean corpuscular volume) and increased red cell distribution width (RDW), may be noted. In a convenience sample of newly arrived western, central, and eastern African refugees to Australia, 20% had ferritin levels that indicated iron deficiency. 2 Studies in the United States have also shown a high prevalence of iron deficiency in Southeast Asian refugees. 8

Iron deficiency likely increases intestinal absorption of lead. 9 To address the high prevalence of iron deficiency in refugee children and decrease their likelihood of developing elevated lead levels after arrival to the United States, CDC recommends that all children aged 6 months to 16 years have a lead level test and all children aged 6 to 59 months receive pediatric multivitamins after arrival (see Lead Section for more details).

Inherited Anemias

Inherited hematologic disorders are common among many refugee populations and should be considered in any refugee who has anemia detected on screening, even if other potential causes exist (e.g., iron deficiency, particularly if not corrected with therapy). These disorders include thalassemias, hemoglobinopathies, enzyme defects, and cell membrane defects. These conditions are most common in malaria-endemic regions, since they may provide some defense against this infection. Most of these conditions are autosomal recessive (except for glucose-6-phosphate dehydrogenase deficiency, which is an X-linked disorder). Therefore, it is important to both identify symptomatic refugees who are homozygous for an abnormal gene and to detect heterozygous carriers, since their offspring may be affected by the disease (Table 2).

Thalassemias are a group of disorders characterized by a decrease in either the alpha or beta globin chain production in red blood cells (RBCs). Globally, most people with thalassemia are born in or are descended from populations in eastern Asia, the Philippines, Indonesia, India, Pakistan and the Middle East. 9 10 A large increase in the prevalence of all forms of thalassemia has been reported in North America, mostly as a result of immigration from Asian and Middle-Eastern groups in recent decades. 10 In California, the rate of hemoglobin H disease (or α-thalassemia) in newborns is high for several Asian immigrant populations: 1/2,500 in Chinese and Vietnamese, 1/1,400 in Filipino, 1/800 in Cambodian, and 1/160 in Laotian newborns. 10

Four conditions make up the α-thalassemias, defined by the number of inherited deletions of the four alpha globin genes. 10 If only one deleted gene is inherited, the person is a silent carrier. Alpha-thalassemia trait occurs when two deleted genes are inherited (either [a_/a_] or [aa/__). Affected people are asymptomatic but usually have a mild microcytic anemia. This condition is important to identify, as the red cell indices resemble IDA; however, administration of iron in alpha-thalassemia trait may be harmful to the patient. When three deleted alpha globin genes are inherited, the result is α-thalassemia (hemoglobin H disease). Affected people have microcytic hypochromic anemia at birth and may have aplastic or hemolytic crises throughout life as a result of viral infections. Hemoglobin H disease may present with complications of gallstone formation or physical exam findings of splenomegaly or growth failure. 8 Roughly half of people with hemoglobin H disease have inherited two deleted alpha globin genes, in combination with a nondeletional mutation called the "constant spring mutation." These people may have a more severe clinical course than those with the classic three-deletion hemoglobin H disease. 8 If a fetus inherits four deleted alpha globin genes, hemoglobin Bart’s disease results. Typically, these fetuses do not survive. 8

People who have inherited one deleted beta globin gene have β-thalassemia minor (trait). These people have mild microcytic anemia but have no symptoms related to the condition. People who have inherited two deleted beta globin genes have β-thalassemia major. Typically symptoms manifest at 8 to 10 months of life, after fetal hemoglobin production has stopped. These patients have severe anemia and fatigue. They may have frontal cranial bossing, other bony changes, and liver and spleen enlargement as a result of extramedullary hematopoesis. Affected people may be jaundiced and are at increased risk of gallstone formation. This condition typically requires frequent blood transfusions and iron chelation. 8

The hemoglobinopathies are conditions characterized by production of abnormal globin chains. Perhaps the most widely known of these conditions is sickle cell disease, due to replacement of glutamic acid by a valine at the sixth amino acid position of the beta chain. Globally, 80% of people affected by sickle cell disease live in or have origins in central Africa. The condition also affects people from Central and South America, the Arabian Peninsula, Middle East, India, and eastern Mediterranean. 11

Hemoglobin E trait, caused by substitution of a lysine by a glutamic acid at position 26 of the beta chain, is another hemoglobinopathy that is frequently present in certain refugee groups, particularly from Southeast Asia. Both heterozygotes and homozygotes are asymptomatic but have hypochromic microcytosis and mild anemia. 12 However, in people who are carriers of both the hemoglobin E gene and the beta-thalassemia gene deletion, severe anemia may result. The prevalence of hemoglobin E is very high in areas of Southeast Asia – nearly 60% in regions of Thailand, Laos, and Cambodia. 10 In California, 25% of Cambodian newborns and just over 10% of Thai and Laotian newborns are hemoglobin E carriers. 10 Hemoglobin E is also seen in many people from Indonesia, Bangladesh, northeast India, Sri Lanka, and parts of the Middle East. 8 12 As with the thalassemias, hemoglobin E red cell indices are similar to IDA; however, unless the patient is also iron deficient, administration of iron will not improve the condition and may be harmful.

Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme present in red blood cells. G6PD deficiency is the most common inherited enzyme deficiency, affecting over 400 million people globally. In certain circumstances it may cause acute hemolytic anemia. The geographic distribution of this condition matches that of the thalassemias listed above, but the condition is particularly common in Southeast Asia. 11 The enzymatic function of G6PD helps recycle glutathione inside RBCs. Glutathione is important for preventing oxidative damage to RBCs, which can occur when hemoglobin interacts with oxidizing agents. RBCs become rigid, resulting in their hemolytic destruction in the spleen and other reticuloendothelial organs. Intravascular hemolysis may also occur. Since the gene that codes for G6PD is located on the X chromosome, men are typically more severely affected than women. Most people with G6PD deficiency are asymptomatic until exposed to oxidizing medications. Examples of particular concern for refugee populations include sulfas, primaquine for malaria, and dapsone, which is commonly used for leprosy and as a prophylactic agent in HIV-infected people. Laboratory findings during an acute hemolytic event include normocytic anemia, increased reticulocyte count, normal liver enzymes, and an elevated indirect bilirubin. A urinalysis may be heme positive without RBCs on microscopic examination. 8

To prevent an acute hemolytic episode, any refugee from a high-risk area should be tested for G6PD activity before oxidizing medications are prescribed. In addition, the new-arrival medical exam should include historical questions to identify past episodes of hemolysis, including prolonged or unusually severe neonatal jaundice, recurrent episodes of anemia, hemoglobinuria, jaundice, or gallstones. If the patient comes from a high-prevalence area, a positive history for any of these conditions warrants testing for G6PD deficiency prior to use of any oxidizing agents. 8

B. Eosinophilia

Eosinophilia may be defined as an eosinophil percentage exceeding 5% or an absolute eosinophil count (AEC) exceeding 400 eosinophils/mm3 (some authors use AEC of >500 mm3). The AEC is generally a better reference, as frequently a patient will have a normal eosinophil percentage when the AEC is elevated, indicating an infection or other condition. If laboratory reports do not include the AEC, it can calculated by multiplying the total white blood count by the eosinophil percentages.

Eosinophilia in a newly arrived refugee most likely indicates the presence of a parasitic infection (see Presumptive Treatment and Medical Screening for Parasites in Newly Arriving Refugees), although other etiologies such as allergies, medication reactions, and atopy, may account for the finding (Table 2).

C. Thrombocytopenia

A variety of conditions may cause thrombocytopenia, including many infectious diseases, although a discussion of the complete differential diagnosis and evaluation of thrombocytopenia is beyond this text. However, some conditions rare in the general U.S. population may be common in certain groups of refugees and are noted here. These include any tropical infection that may cause hypersplenism (especially schistosomiasis, visceral leishmaniasis and malaria, or more rarely, brucellosis). In addition, certain infections that may not elicit clinical symptoms during the examination may cause thrombocytopenia through other mechanisms, such as HIV infection (up to 40% of infected people will have low platelet counts) or acute infection with malaria in a semi-immune person. 8

D. Other Conditions

A CBC with differential may reveal clues to a wide range of other, less common disorders such as malignancy (e.g., leukemia), vitamin deficiencies indicated by megaloblastic anemia (e.g., B12, folate), anemia of chronic disease, and endocrinopathies (e.g. thyroid disease) (Table 2).

Initial evaluation of anemia and follow-up testing:

If anemia is present, the cause should be sought (Table 2). The large number of differential diagnoses and often multifactorial causes mean that an anemia cannot be assumed to be due to common iron deficiency. 6 All patients with a microcytotic anemia should have iron studies checked. If iron deficiency is not present or is unresponsive to therapy, hemoglobin electrophoresis should be performed to identify thalassemias and hemoglobinopathies. Alpha-thalassemia trait cannot be diagnosed by hemoglobin electrophoresis beyond the newborn age; it can only be inferred as the cause of iron-nonresponsive microcytic anemia in a person with a normal hemoglobin electrophoresis and no other identifiable source of microcytic anemia. 8

Additional tests to consider include blood lead levels for any person with anemia or microcytosis (although blood lead testing is routinely recommended in children 6 months to 16 years; see Lead Section). In addition, given the very high infection rates, H. pylori, which results in peptic ulcer disease, should be considered in people with microcytic anemias, especially among those who do not respond well to iron replacement or who have abdominal complaints. 13

If eosinophilia is detected, the necessary follow-up testing depends on the type of pre-departure parasite treatment the refugee received (See Presumptive Treatment and Medical Screening for Parasites in Newly Arriving Refugees).

The evaluation of thrombocytopenia may be extensive. Any refugee from a malaria-endemic country should be tested for malaria as an initial step. Initial or repeat testing for HIV should be considered. When thrombocytopenia and splenomegaly are present, the patient should be referred to a specialist for evaluation for infections (e.g., schistosomiasis, leishmaniasis, and malaria), as well as other possible causes, such as malignancy.

After a careful history and physical examination, most clinicians will begin evaluation with a peripheral blood smear for morphology. An initial differential diagnosis may be generated by using the red blood cell indices.

Table 2. Common causes of anemia in refugees and recommended initial testing
AnemiaCommon Causes in RefugeesFrequent Initial Laboratory Investigations
Microcytic anemia c
  • Iron-deficiency anemia d
  • Thalassemias and hemoglobinopathies
  • Iron studies (serum iron, total iron binding capacity, iron saturation, ferritin)
  • Reticulocyte count
  • Hemoglobin electrophoresis e
  • Lead level f
Normocytic anemia cChronic diseases
  • Hepatic or renal disease
  • Neoplasms
  • Collagen vascular disease
  • Infections
    • Protozoal (e.g., malaria, leishmaniasis)
    • Bacterial (e.g., tuberculosis)
    • Viral (e.g., hepatitis, mononucleosis)
  • Reticulocyte count
Macrocytic anemia c
  • Vitamin B-12 deficiency
  • Folate deficiency
  • Medications
  • Alcohol
  • Thyroid disease
  • Liver disease
  • HIV infection
  • Serum B12 and folate levels
  • Red blood cell folate level
  • Thyroid function tests
  • Reticulocyte count
  • c Commonly multifactorial in refugees. If high, RDW may have mixed microcytic, normocytic or macrocytic causes.
  • d Many causes, including nutritional, direct blood loss (e.g., menses, ulcer disease, carcinoma, hookworm infection), chronic disease.
  • e If no iron deficiency or if iron-deficiency anemia is not completely corrected with iron therapy.
  • f Particularly important in children. Not a cause of anemia, but rather a consequence of iron deficiency.

Note: G6PD does not cause anemia unless oxidative stress induces hemolytic anemia. It should be checked, particularly in Southeast Asian populations, before medications are prescribed with oxidizing potential (e.g., sulfa agents, primaquine).

2. Urinalysis

Who Should Be Tested

There is no evidence that routine urinalysis is a cost-effective screening examination. It may be considered in newly arrived refugees of all ages and ethnicities who are developmentally mature enough to provide a clean-catch urine specimen. A bag specimen may be checked for younger children, if clinically indicated, with confirmation of positive findings by catheterization. 5 This recommendation is more conservative than the current American Academy of Pediatric guidelines for children residing in the United States, because of the higher prevalences of specific conditions that may be detected in refugee children (e.g., Schistosoma haematobium).

Potential Disorders Detected

A. Schistosoma haematobium

Schistosoma haematobium is parasite present in Africa and the Middle East. In some populations (e.g., people living in endemic areas of Nigeria and Ghana), infection rates may exceed 90%. 15 16 17 Infection presents with intermittent microcytic or gross hematuria, which may be accompanied by dysuria or increased frequency. Infection is highly associated with squamous cell carcinoma of the bladder. 6 Although the infection is frequently accompanied by an AEC, confirmation is made by schistosomiasis serologic tests and/or urine ova and parasite examination. Schistosomiasis in refugees is discussed further in the intestinal parasites guidelines (

B. Renal Diseases

Although not a primary reason for a screening urinalysis, clues to the presence of many different types of systemic and renal disease may be incidentally revealed, and abnormal results should be investigated.

C. Systemic Diseases

A positive dipstick for glucose is suggestive of diabetes. Although no evidence supports formal screening of nonimmigrant adults for diabetes by fasting glucose measurements, refugee populations have never been studied. Newly arriving refugees constitute a medically vulnerable population in which realities such as lack of awareness, difficulties of navigating complicated health-care systems, and sporadic medical insurance coverage may sway the balance in favor of screening for asymptomatic diabetes. Although urinalysis is inferior to fasting blood glucose, the presence of glucosuria is suggestive of diabetes.

D. Sexually Transmitted Infections (STIs)

A urinalysis can give clues to the presence of sexually transmitted infections. A positive dipstick for leukocyte esterase or increased numbers of white blood cells in the microscopic exam is suggestive of chlamydia or gonoccocal infection. However, because of its low sensitivity this test should not be considered an effective screening method for these infections. For example, in one study, the presence of leukocyte esterase was only 61% sensitive for chlamydia infections in males. 14 For a complete discussion of screening refugees for STIs, see Screening for Sexually Transmitted Infections.

3. Chemistries

No evidence supports universal screening of asymptomatic refugees for electrolyte and other chemistry abnormalities. However, a basic panel including blood urea nitrogen and creatinine should be considered if indicated by signs, symptoms, or comorbidities. A basic panel may also be considered in certain groups with high rates of chronic renal disease, such as the Hmong. In addition, uric acid in Hmong refugees may be considered, since the prevalence of hyperuricemia and related diseases such as gout and end-stage renal disease is high in this population.

4. Newborn Screening

There is no evidence that newborn screening is beneficial in refugee infants or children. However, if a newborn refugee infant is seen for refugee medical screening, a newborn screening panel, as dictated by the respective state, should be performed.

5. Cardiovascular and Lipid Disorder Screening

Refugees should be screened for cardiovascular and lipid disorders in accordance with the US Preventive Services Task Force (USPSTF) guidelines (Table 3). 18 Although blood pressure and nonfasting serum lipid testing can be performed at the new-arrival medical screening examination, other screening tests recommended by the USPSTF may not be conducted at this visit but should be done in a reasonable time frame after arrival. Adults found to have hyperlipidemia or hypertension should be formally screened for diabetes with a fasting blood glucose measurement, in accordance with USPSTF guidelines, and should be referred for long-term management.

Table 3. U.S. Preventive Services Task Force Guidelines for routine medical screening for lipid disorders, hypertension, and abdominal aortic aneurysm.
Lipid disorders
  • Screen and treat men ≥35 years and women ≥45 years of age for lipid disorders by obtaining, at the minimum, total cholesterol and high-density lipoprotein levels. These can be checked in a nonfasting state.
  • Screen and treat men 20-35 years and women 20-45 years of age if they have increased risk for coronary heart disease (diabetes, tobacco use, hypertension, family history of cardiovascular disease before age 50 in male relatives or age 60 in female relatives, or a family history suggestive of familial hyperlipidemia)
  • Screen men and women ≥18 years g
Abdominal aortic aneurysm
  • Screen by ultrasonography men aged 65-75 years of age if they have ever smoked

Through acculturation, refugees may adopt diets and lifestyles that increase their risks of obesity, diabetes, and cardiovascular diseases. Because of competing concerns of settling in a new country, the new-arrival screening visit is not the ideal setting to discuss regular exercise and healthy diets, but the importance of yearly preventive visits should be discussed, and people with disease may be identified. Given clinical latitude, for refugees who are especially well adjusted it is appropriate to discuss likely future issues such as obesity, diet, and exercise. Translated and culturally sensitive education materials should be distributed when available.

6. Cancer Screening

Immigrants are less likely than the general U.S. population to receive screening tests for cervical, breast and colorectal cancers. 19 Foreign-born populations may be adversely effected due to a large health-care disparity in screening for cancers and may experience worse disease outcomes. 19 Many factors, particularly limited access to care and cultural barriers, account for these disparities. Interestingly, socioeconomic factors, including education and income levels, do not appear to strongly influence the likelihood that refugees will obtain appropriate screening tests. 19

Refugees, as with all U.S. populations, should receive preventive screening according to USPSTF Cancer Screening Guidelines (Table 4 ). The new-arrival medical screening examination may not be the ideal time to perform invasive medical screening examinations (e.g., pelvic examinations), since many refugees have experienced sexual assault or other traumatic events. However, if an appropriate environment can be created, trust can be established, cultural norms respected, and the risk of additional trauma to the refugee minimized, the visit does present a possible opportunity to provide more invasive cancer screening. Even when invasive examinations are not possible, measures can be taken during new-arrival screening to promote access to future health care and reduce cultural barriers, which may increase cancer screening in refugee populations. Such measures include identifying a primary-care provider, explaining the importance of annual preventive care visits (promoting the message that medical care is for prevention and not just disease), and using professional interpreters to help educate refugees on the benefits of preventive screening in a culturally sensitive manner. In addition, behavioral risks can be addressed, such as avoiding the use of tobacco, alcohol, and other substances (e.g., khat, betel nut) that predispose toward cancer.

Refugee populations are at a disproportionally increased risk for cancers that occur in the developing world, such as cancers of the liver, esophagus, and stomach. 20 21 22 23 There are no specific guidelines in the United States. for screening for cancers that occur disproportionally in migrants from the developing world, so the clinician must have a low threshold for investigation and early identification of cancers that are common in these populations but not encountered frequently in the United States.

Two extremely prevalent predisposing medical conditions, hepatitis B and H. pylori, are noted here. Hepatitis B is the leading cause of hepatocarcinoma worldwide. Although screening guidelines are under development for hepatocarcinoma in hepatitis B-infected people in the United States, they are not published yet. People with known hepatitis B infection should be referred for possible treatment. In addition, follow-up should be arranged for infected people to be screened on at least a semi-annual basis for early detection of disease by imaging (i.e., right upper quadrant ultrasound) and blood tests (alpha-fetoprotein and aspartate aminotransferase).

Refugees also have extremely high rates of H. pylori infection, which increases risk for gastric cancer. 24 Eradication therapy for H. pylori may decrease this risk, especially if administered before the appearance of precancerous lesions. However, experts to date have not recommended screening asymptomatic people in high-risk populations; thus, clinical judgment must be used when working in populations with very high rates of infection and high rates of gastric carcinoma.

Table 4. Summary of USPSTF cancer screening guidelines 18
Cervical cancer
  • Women should be screened with cervical cytology (Papanicolaou smears) at least every 3 years starting at age 21 or within 3 years of onset of sexual activity (whichever comes first).
    (Since the sensitivity of a single smear may be 60%-80%, most organizations suggest obtaining annual smears until 2 or 3 consecutive negative results are obtained before spacing screening to every 3 years.)
  • Screening can be discontinued after age 65 in women with previous negative screenings.
  • Screening is not required in women who have had a total hysterectomy for benign disease.
Breast cancer
  • Biennial screening mammography should be offered to women aged 50-74 years of age. Further recommendations are available from the U.S. Preventive Services Task Force 18
Colorectal cancer
  • Men and women ≥ 50 years of age should be screened by one of the following methods:
    • Fecal occult blood testing of 3 consecutive stools annually
    • Flexible sigmoidoscopy or double-contrast barium enema every 5 years
    • Colonoscopy every 10 years

7. Female Genital Cutting (also known as female circumcision, female genital mutilation, and female genital excision)

Female genital cutting refers to all procedures involving partial or total removal of female genitalia or other injury to female genital organs for any cultural, religious or otherwise nontherapeutic reasons. This practice is common in many refugee populations, particularly those from East Africa (i.e. Somalia, Ethiopia, Sudan), although the practice is pervasive throughout the world. This controversial practice is considered a human rights violation by many, and it is illegal in the United States in people under 18 years of age. The World Health Organization (WHO) has condemned the practice and is making efforts to end it. The practice poses adverse medical consequences, including direct complications from the procedure (anesthesia or sedation complications, bleeding, acute infection), increased risk of death for both mother and infant in subsequent pregnancies, post-traumatic stress disorder, and urinary tract infections, among others. In addition, there may be adverse consequences for the woman’s sexual well-being.

An external genital examination will reveal whether a girl or woman has undergone this procedure. Although this examination is required on the overseas medical evaluation, it may not have been performed, and the domestic medical screening evaluation presents an opportunity to identify women who have had the procedure. The exam may also provide opportunities to interrupt the practice in future generations. When the practice is identified, the clinician should record what type of procedure was performed (Table 5). Culturally sensitive counseling and educational materials should be offered and, when necessary, referrals provided (e.g., for complications or posttraumatic stress disorder). The refugee can be informed that the procedure is illegal in the United States.

More detailed information regarding female genital cutting is available from the World Health Organization.

Table 5. World Health Organization Categorization of Female Genital Cutting
Type IPartial or total removal of the clitoris (clitorectomy).
Type IIPartial or total removal of the clitoris and the labia minora, with or without excision of the labia majora.
Type IIINarrowing of the vaginal orifice with creation of a covering seal by cutting and appositioning the labia minora and/or majora (infibulation), with or without excision of the clitoris.
Type IVAll other harmful procedures to the female genitalia for nonmedical purposes (e.g., piercing, incising, pricking, scraping, and cauterizating)


  1. Office of Immigration Statistics. U.S. Department of Homeland Security. Refugees and Asylees: 2012. Available at: [PDF]. Accessed 7/1, 2014.
  2. Tiong AC, Patel MS, Gardiner J, et al. Health issues in newly arrived African refugees attending general practice clinics in Melbourne. Med J Aust. 2006;185:602-6.
  3. Catanzaro A, Moser RJ. Health status of refugees from Vietnam, Laos, and Cambodia. JAMA. 1982;247:1303-8.
  4. Geltman PL, Radin M, Zhang Z, Cochran J, Meyers AF. Growth status and related medical conditions among refugee children in Massachusetts, 1995-1998. Am J Public Health. 2001;91:1800-5.
  5. Hayes EB, Talbot SB, Matheson ES et al. Health Status of Pediatric Refugees in Portland ME. Archives of Pediatric Adolescent Medicine, Vol 152, June 1998: 564-8.
  6. Stauffer WM, Kamat D, Walker PF. Screening of international immigrants, refugees, and adoptees. Prim Care. 2002;29:879-905.
  7. Pottie K, Topp P, Kilbertus F. Case report: Profound anemia. Chronic disease detection and global health disparities. Can Fam Physician. 2006;52:335-6.
  8. Jeng MR, Vichinsky E. Hematologic problems in immigrants from Southeast Asia. Hematol Oncol Clin North Am. 2004;18:1405-22.
  9. Wright RO, Tsaih SW, Schwartz J, Wright RJ, Hu H. Association between iron deficiency and blood lead level in a longitudinal analysis of children followed in an urban primary care clinic. J Pediatr. 2003;142:9-14.
  10. Vichinsky EP. Changing patterns of thalassemia worldwide. Ann N Y Acad Sci. 2005;1054:18-24.
  11. Theodorsson E, Birgens H, Hagve TA. Haemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in a Scandinavian perspective. Scand J Clin Lab Invest. 2007;67:3-10.
  12. Rees DC, Styles L, Vichinsky EP, Clegg JB, Weatherall DJ. The hemoglobin E syndromes. Ann N Y Acad Sci. 1998;850:334-3.
  13. Malfertheiner P, Megraud F, O'Morain C, et al. Current concepts in the management of Helicobacter pylori infection: The Maastricht III consensus report. Gut. 2007;56:772-81.
  14. Black CM. Current methods of laboratory diagnosis of Chlamydia trachomatis infections. Clin Microbiol Rev 1997;10(1):164-80.
  15. Aryeetey ME, Wagatsuma Y, Yeboah G, et al. Urinary schistosomiasis in southern Ghana: 1. Prevalence and morbidity assessment in three (defined) rural areas drained by the Densu River. Parasitol Int 2000; 49(2):155-63.
  16. Garba A, Tohon Z, Sidiki A, Chippaux JP, de Chabalier F. Efficacy of praziquantel in school-aged children in a hyperendemic zone for Schistosoma haematobium (Niger, 1999). Bull Soc Pathol Exot 2001; 94(1):42-5.
  17. Amazigo UO, Anago-Amanze CI, Okeibunor JC. Urinary schistosomiasis among school children in Nigeria: consequences of indigenous beliefs and water contact activities. J Biosoc Sci 1997; 29(1):9-18.
  18. U.S. Preventive Services Task Force. Recommendations. Available at: Accessed 7/2, 2012.
  19. Goel MS, Wee CC, McCarthy EP, Davis RB, Ngo-Metzger Q, Phillips RS. Racial and ethnic disparities in cancer screening: The importance of foreign birth as a barrier to care. J Gen Intern Med. 2003;18:1028-1035.
  20. Miller BA, Chu KC, Hankey BF, Ries LA. Cancer incidence and mortality patterns among specific Asian and Pacific Islander populations in the U.S. Cancer Causes and Control 2008;18(3):227-56.
  21. Kem R, Chu KC. Cambodian cancer incidence rates in California and Washington, 1998-2002. Cancer 2007;110(6):1370-5.
  22. Ross JA, Xie Y, Kiffmeyer WR, et. al. Cancer in the Minnesota Hmong population. Cancer 2003;97(12):3076-9.
  23. Nasseri K, Mills PK, Allan M. Asian Pac J Cancer Prev 2007;8(3):405-11.
  24. Verdu EF, Fraser R, Tiberio D, et al. Prevalence of Helicobacter pylori infection and chronic dyspeptic symptoms among immigrants from developing countries and people born in industrialized countries. Digestion. 1996;57:180-5.
Contact Us:
  • Centers for Disease Control and Prevention
    1600 Clifton Rd
    Atlanta, GA 30333
  • 800-CDC-INFO
    TTY: (888) 232-6348
  • Contact CDC–INFO The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC-INFO