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Compendium of Evidence-Based Interventions and
Best Practices for HIV Prevention

Risk Reduction (RR) Chapter

The Prevention Research Synthesis (PRS) Project has been conducting on-going systematic reviews (i.e., Risk Reduction (RR) Efficacy Review) to identify evidence-based interventions (EBIs) that show evidence of efficacy in changing sex or drug-injection behaviors that directly impact HIV-transmission risk. Additional details about the RR Chapter or PRS can be obtained by contacting PRS.

Updated on April 1, 2015

Beginning in 2015, PRS will focus only on evaluating RR interventions for priority populations, in line with DHAP’s High-Impact Prevention (HIP) approach. More information about upcoming changes to the PRS RR review process can be found here.

Starting October 2014, CDC no longer funds the implementation of the RESPECT intervention after an extensive review of recent evidence and consultation with CDC and external experts.

What's New in the Risk Reduction Chapter of the Compendium

The NEW individual-, group-, couple-, or community-level (ILI, GLI, CPL, CLI) risk reduction (RR) evidence-based behavioral interventions (EBIs):


The Complete Risk Reduction Chapter Includes 93 RR EBIs

Updated on April 1, 2015

56 Best-evidence interventions:

  • 55 individual-, group-, and couple-level EBIs
  • 1 community-level EBI

37 Good-evidence interventions:

  • 32 individual- and group-level EBIs
  • 0 couple-level EBIs
  • 5 community-level EBIs

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