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HIV/AIDS Prevention Research Synthesis Project

The HIV/AIDS Prevention Research Synthesis (PRS) Project was initiated by the Prevention Research Branch, Division of HIV/AIDS Prevention (DHAP) at CDC in 1996 to systematically review and summarize HIV behavioral prevention research literature. The goal of PRS is to translate scientific evidence from the research literature into practical information that can be used by prevention providers, state and local health departments throughout the United States, and HIV prevention researchers. PRS activities consist of systematic reviews, which include the efficacy reviews featured on this site that identify HIV evidence-based behavioral interventions (EBIs), and other activities. For a list of all PRS-related publications, go to PRS publications.


PRS works together with CDC’s Replicating Effective Programs (REP) and Diffusion of Effective Behavioral Interventions (DEBI) projects to translate scientific evidence into program practice.

PRS conducts systematic reviews to identify evidence-based interventions based on rigorous efficacy criteria. REP works with researchers, in collaboration with community-based partners, to translate evidence-based interventions into everyday language and develop user-friendly packages of materials.

Once the interventions are packaged, the DEBI project coordinates the dissemination of these packaged interventions. The Capacity Building Branch (CBB) in the Division of HIV/AIDS Prevention (DHAP) provides training and technical assistance on the DEBI packages through the National Network of STD/HIV Prevention Training Centers (PTCs) and offers culturally appropriate capacity building assistance through other technical assistance programs.

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