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Cause and Incidence

B virus infection is caused by the zoonotic agent Macacine herpesvirus (formerly Cercopithecine herpesvirus 1 [CHV-1], an alphaherpesvirus) commonly found among macaques—a genus of Old World monkeys that serve as the natural host. B virus infection in macaques results in a disease similar to herpes simplex virus infection in humans.

B virus infection in macaques is usually symptom-free or causes only mild disease, but in humans the infection can be fatal.

Reported cases of infection in humans are very rare; since the identification of the virus in 1932, there have only been 31 documented human infections by B virus, 21 of which were fatal. Most of these infections have resulted from animal bites or scratches or from percutaneous inoculation with infectious materials. However, in 1997 a researcher died from B virus infection following a mucosal splash exposure (see Fatal Cercopithecine herpesvirus 1 (B virus) Infection Following a Mucocutaneous Exposure and Interim Recommendations for Worker Protection. Morbidity and Mortality Weekly Report 1998).

B virus is classified as a select agent, with the potential to pose a threat to public health and safety, by the U.S. Public Health Service, Department of Health and Human Services (see the Code of Federal Regulations—42CFR73.3).


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