Healthcare-associated infection Research

What’s New in Prevention Epicenter Research

The CDC funded Prevention Epicenters are dedicated to advancing prevention research toward CDC’s goal to eliminate Healthcare Associated Infections. Read about the current progress being made toward that goal as we spotlight Multicenter Prevention Epicenter Projects and Preliminary Research Findings presented at ID Week.

Spotlight on Multi-Center Projects

MRSA Project: The REDUCE MRSA project is a cluster randomized trial designed to assess the comparative effectiveness of three principal strategies for the prevention of MRSA+ clinical cultures in intensive care units. This study is a collaborative effort of the CDC Prevention Epicenters, Agency for Healthcare Research and Quality (AHRQ), and the Hospital Corporation of America. REDUCE MRSA is a unique clinical study that was conceived out of Prevention Epicenters research. Conducting the study on a larger scale was made possible through partnership with AHRQ.
Streamlined Surveillance for Ventilator-Associated Pneumonia: Reducing Burden and Demonstrating Preventability (sVAP) Project: Ventilator-associated pneumonia (VAP) is a common and morbid complication of mechanical ventilation. Efforts to accurately characterize the prevalence of VAP and drive improvements have been hampered by limitations of the current surveillance definition. A new streamlined surveillance defintion (sVAP) has been shown to be objective, efficient, and a potent predictor of patient outcomes but the feasibility of using this definition for routine operational surveillance in diverse settings and the capacity of the definition to reflect meaningful improvements in patient care have not yet been evaluated. A prospective, multicenter comparison of conventional versus sVAP surveillance to determine the feasibility and clinical significance of streamlined surveillance in diverse settings under operational conditions is under way. One aim of this multicenter study is to evaluate the impact of an opt-out protocol for daily sedative interruptions and spontaneous breathing trails on conventional and sVAP rates. Check ‘What’s New’ in January 2013 for the roll-out of the Wake Up & Breathe Collaborative page.

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Spotlight on Preliminary Research Findings

Researchers from the 5 Prevention Epicenters will be presenting their findings on Health Care Associated Prevention Research at ID Week 2012, October 16-21st in San Diego California. ID Week 2012, Advancing Science-Improving Care, will feature the latest science and bench-to-bedside approaches in prevention, diagnosis, treatment, and epidemiology of infectious diseases across the lifespan. Click the links below to view full abstracts developed from the latest Prevention Epicenter research.

Methicillin-Resistant Staphylococcus Aureus (MRSA)

Rosie D. Lyles-Banks, MD, MS; Michael Y. Lin, MD, MPH, Karen Lolans, BS, Mary K. Hayden, MD, Hong Li, MS, Alexander J. Kallen, MD, MPH, Stephen G. Weber, MD, MS, Robert A. Weinstein, MD, William E. Trick, MD
Methicillin-Resistant Staphylococcus Aureus (MRSA) Colonization among Neonatal and Pediatric Intensive Care Unit (ICU) Patients Following an Active Surveillance Mandate
Session: NICU/Pediatric Infection Prevention
October 18, 2012; 12:30-2:00 pm
Poster Presentation
Han, JH, Edelstein PH, Bilker WB, Lautenbach E
The effect of staphylococcal cassette chromosome mec (SCCmec) type and clinical outcomes in methicillin-resistant Staphylococcus aureus bacteremia.
Session: MRSA Molecular Epidemiology
October 18, 2012
Poster Abstract Session
Han JH, Edelstein PH, Lautenbach E
Reduced vancomycin susceptibility and staphylococcal cassette chromosome mec (SCCmec) type distribution in methicillin-resistant Staphylococcus aureus bacteremia
Session: MRSA Molecular Epidemiology
October 18, 2012
Poster Abstract Session
Huang SS, Septimus E, Kleinman K, Moody J, Hickok J, Avery TA, Lankiewicz J, Gombosev A, Terpstra L, Hartford F, Hayden MK, Jernigan JA, Weinstein RA, Fraser VJ, Haffenreffer K, Cui E, Kaganov RE, Lolans K, Perlin J, Platt R for the CDC Prevention Epicenters and the AHRQ DEcIDE Network and Healthcare-Associated Infections Program
Randomized Evaluation of Decolonization vs. Universal Clearance to Eliminate Methicillin-Resistant Staphylococcus aureus in ICUs (REDUCE MRSA Trial)
October 19, 2012; 4:15-4:30 pm
Oral Presentation
SHEA Lectureship Abstract

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Multi-Drug Resistant Organisms

Deverick Anderson, MD MPH, Maria F. Gergen, MT (ASCP), Emily Smathers, MPH, Daniel J. Sexton, MD, David J. Weber, MD, MPH, William A. Rutala, PhD, MPH and the CDC Prevention Epicenter Programs
Effectiveness of Ultraviolet (UV)-C light against C. difficile, Acinetobacter, and Vancomycin-Resistant Enterococci in the Hospital Environment
Session: Disinfection and Sterilization
October 19, 2012 ; 12:30-2:00pm
Poster Abstract Session
Han JH, Nachamkin I, Tomoleo P, Bilker WB, Lautenbach E
Risk factors for efflux pump overexpression in fluoroquinolone-resistant Escherichia coli.
Session: Antimicrobial Resistance: Clinical and Basic Studies
October 19, 2012
Poster Abstract Session
Chen, LF, Sexton,DJ, Anderson, DJ
Widespread Dissemination of Group 1 CTX-M Genotype 15 Extended Spectrum Beta-Lactamase Producing Enterobacteriaceae among Patients Presenting to Community Hospitals - Clinical and Molecular Epidemiology.
Session: Epidemiology of Multiple Drug-Resistant Gram Negative Rods
October 20, 2012; 12:30-2:00pm
Poster Abstract Session
Han JH, Kasahara K, Edelstein PH, Bilker WB, Lautenbach E
Risk Factors for Infection or Colonization with CTX-M Extended-Spectrum Beta-Lactamase (ESBL)-Positive Escherichia coli
Session: Epidemiology of Multiple Drug Resistant Gram Negative Rods
October 20, 2012
Poster Abstract Session
Datta R, Kleinman K, Rifas-Shiman S, Placzek H, Lankiewicz JD, Platt R, Huang SS
Failure to Account for Treatment Indication Impacts Antimicrobial Predictors of Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Resistant Enterococci (VRE) Acquisition
Session: MRSA Screening and Prevention
October 20, 2012; 12:30-2:00pm
Poster Presentation

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Surgical Site Infections

Calderwood MS, Kleinman K, Bratzler DW, Ma A, Bruce CB, Kaganov RE, Canning C, Platt R, Huang SS.
Using Medicare Claims to Identify U.S. Hospitals with a High Rate of Surgical Site Infection Following Hip Arthroplasty
Session: Surveillance HAIs: Advancing the Science
October 19, 2012; 12:30-2:00pm
Poster Presentation
Calderwood MS, Kleinman K, Tse A, Jin R, Platt R, Lee GM
Examining the Impact of Medicare's Policy of Non-Payment for Preventable Complications on Rates of Mediastinitis following Coronary Artery Bypass Graft Oral Abstract Session: Impact of National Policy on HAI Reporting and Prevention
October 19, 2012; 2:30-2:45 pm
Oral Presentation
Alyssa R. Latourneau, Michael S. Calderwood, Susan S. Huang, Dale W. Bratzler, Allen Ma, Richard Platt, Deborah Yokoe for the CDC Prevention Epicenters
Claims-Based Surveillance Improves Detection of Surgical Site infections Following Hysterectomy and Colorectal Surgery
Session: Surgical Site Infections (SSI)
October 20, 2012; 8:45-9:00 am
Oral Presentation
Deborah S. Yokoe, Susan S. Huang, Julie Lankiewicz, Rebecca Kaganov, Christina Bruce, Sandra Berrios-Torres, and Richard Platt for the CDC Prevention Epicenters Program
Managed Care Claims Data for Surgical Site Infection (SSI) Surveillance Following Ambulatory Surgery
Session: Surgical Site Infections (SSI)
October 20, 2012; 9:30-9:45am
Oral Presentation

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Ventilator Associated Pneumonia

Klompas M, Sinuff T, Jiang X, Day A, Muscedere J for the Canadian Critical Care Trials Group
The Morbidity and Preventability of Ventilator- Associated Conditions Impact of National Policy on HAI Reporting and Prevention
October 19, 2012; 3:15-3:30 pm
Oral Presentation

Blood Stream Infections

Faisal Alasmari, Nupur D. Kittur, Anthony J Russo, Kathleen M. McMullen, Kathleen Rensing, Erik R. Dubberke, Jennie L. Mayfield
Impact of Alcohol Impregnated Protectors on Incidence of Catheter- Associated Blood Stream Infections
October 18, 2012
Poster Abstract Session