Information for Health Care Workers
Burkholderia mallei, a gram-negative bacillus.
Systemic invasion can occur with resulting chronic abscessation.
The disease is diagnosed in the laboratory by isolating Burkholderia mallei from blood, sputum, urine, or skin lesions. Serologic assays are not available.
Glanders continues to be extremely rare in humans. In 2000, one case occurred in a research laboratory worker in the U.S. after accidental exposure.
While no national or state surveillance exists, the case-fatality rate is over 50% with traditional antibiotic treatment. Susceptibility data, however, suggest newer antibiotics should be efficacious.