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Genomics & Health Impact Update

Volume 32  Number 19  May 15-22, 2014About the Update

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Reports and Publications


Doctor Explaining Diagnosis To Her Female Patient

Enabling a genetically informed approach to cancer medicine: A retrospective evaluation of the impact of comprehensive tumor profiling using a targeted next-generation sequencing panel
Johnson DB, et al. Oncologist 2014 May

Germline BRCA mutation evaluation in a prospective triple-negative breast cancer registry: implications for hereditary breast and/or ovarian cancer syndrome testing
Sharma P, et al. Breast Cancer Res Treat 2014 May

Influence of a genomic classifier on postoperative treatment decisions in high-risk prostate cancer patients: Results from the PRO-ACT study
Michalopoulos SN, et al. Curr Med Res Opin 2014 May

Patient-reported hereditary breast and ovarian cancer in a primary care practice.
Quillin JM, et al.  J Community Genet. 2014 Apr;5(2):179-83.

Few women at high-risk for hereditary breast and ovarian cancer receive genetic counseling, EurekAlert, May 8

Predictors that influence contralateral prophylactic mastectomy election among women with ductal carcinoma in situ who were evaluated for BRCA genetic testing
Elsayegh N, et al. Ann Surg Oncol 2014 May

Prostate Cancer (PCa) risk variants and risk of fatal PCa in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
Shui IM, et al. Eur Urol. 2014 Jun;65(6):1069-75.

Genetic variants in predicting aggressive prostate cancer: “Ready for prime time?”  
Adriana C. Vidal  et al. European Urology: 01 June 2014

Gene expression analysis for prostate cancer management, Blue Cross Blue Shield Health Technology Assessment Report, May 2014

Ethics, Policy & Law

stacked books with a gavel infront of them

"Would you test your children without their consent?"
Brierley KL, et al. Fam Cancer 2014 May

Return of genomic results to research participants: The floor, the ceiling, and the choices in between
Jarvik GP, et al. Am J Hum Genet 2014 May

Routes for breaching and protecting genetic privacy
Yaniv Erlich et al. Nature Reviews Genetics, May 8, 2014

International code of conduct for genomic and health-related data sharing, Global Alliance on Genomics & Health, May 5

Family History

Infectious Diseases

an infected cell

Dynamics and associations of microbial community types across the human body
Ding T, Schloss PD. Nature 2014; 509:357-360.

Lung microbiota promotes tolerance to allergens in neonates via PD-L1.
Eva S Gollwitzer et al. Nature Medicine, May 11, 2014

The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host–parasite interaction
Jackson AP, et al. Nucl Acids Res, May 5, 201

Visualizing the ocular microbiome
Shaikh-Lesko R. The Scientist, May 12, 2014.

Virus discovery: are we scientists or genome collectors?
Canuti M, van der Hoek L. Trends Microbiol. 2014 May;22(5):229-31.

Microbiome therapy gains market traction, by Sara Reardon, Nature News, May 13

Reviews, News & Commentaries

stacked papers

Clinical informatics: Prospects for a new medical subspecialty
Don E. Detmer et al. JAMA, May 13, 2014

Distinguishing between “function” and “effect” in genome biology.
W. Ford Doolittle et al. Genome Biology & Evolution, May 8, 2014

Epigenetics: Obesity paves the highway for colon cancer
Simon W. Beaven et al.  Sci Transl Med 7 May 2014

The biology and genetics of obesity — a century of inquiries
Jou C, et al. N Engl J Med 2014; 370:1874-1877 2014 May 15

IOM releases new report: Improving the efficiency and effectiveness of genomic science translation - workshop summary

Improving diagnosis and care for inherited heart conditions, by Dr Philippa Brice, PHG Foundation, May 15

Integrating host and tumor genome data holds promise for understanding cancer risk, NCI, May 15

Your DNA enters the digital age: Q&A with NIH director, USA Today, May 15

Genomic Health's Oncotype DX® becomes first multi-gene test for cancer management to be included in National Institutes of Health's (NIH) Genetic Testing Registry, Market Watch, May 14

Phase II feasibility study tests four molecular-based hypotheses in advanced colorectal cancer, by Matthew Stenger, ASCO Post, May 13

Atlas shows how genes affect our metabolism-New atlas of molecules paves the way for improved understanding of metabolic diseases, Sanger Institute, May 11

Health of the nation: why genomics must be made to deliver, PHG Foundation, May 8

New genomics technique could improve treatment and control of malaria,Wellcome Trust, May 8

NHGRI video: Dir. Eric Green discusses biomedical big data, You Tube, Apr 23

Is genetic information different? Lively NHGRI video debate at the Smithsonian (2014)

Tools and Databases

numbers on a grid

An atlas of genetic influences on human blood metabolites
Shin SY, et al. Nature Genetics 2014 May 11

New atlas of molecules paves the way for improved understanding of metabolic diseases, Medical Xpress, May 11

PhenX: Managing the mass of measures: Real people's real data, webinar, Genetic Alliance, May 12

Genomics and precision oncology: What's a targeted therapy for cancer? An updated list of approved drugs from the National Cancer Institute (April, 2014)

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CDC-Authored Genomics Publications

hand holding a pen on an article

CDC authors are indicated in bold

Detection of Rickettsia rickettsii, Rickettsia parkeri, and Rickettsia akari in skin biopsy specimens using a multiplex real-time PCR assay
Amy M. Denison, Bijal D. Amin, William L. Nicholson, and Christopher D. Paddock Clin Infect Dis, May 14, 2014.

Trichomonas vaginalis metronidazole resistance is associated with single nucleotide polymorphisms in the nitroreductase genes ntr4Tv and ntr6Tv
Paulish-Miller TE, Augostini P, Schuyler JA, Smith WL, Mordechai E, Adelson ME, Gygax SE, Secor WE, Hilbert DW. Antimicrob Agents Chemother. 2014 May;58(5):2938-43.

View previous CDC-authored publications

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About the Genomics & Health Impact Update

The Update includes genomics and health impact news and publications, CDC announcements, reports, blogs, podcasts, and other products. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science.  To receive the update electronically every week sign-up here.


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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.


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