Genomics & Health Impact Update
Volume 32 Number 6 February 13-20, 2014About the Update
A randomized trial to increase colonoscopy screening in members of high risk families in the Colorectal Cancer Family Registry and Cancer Genetics Network
Lowery JT, et al. Cancer Epidemiol Biomarkers Prev 2014 Feb
Cancer systems biology: a peek into the future of patient care?
Henrica M. J. Werner et al. Nature Reviews Oncology, Feb2014
Economics of genomic testing for women with breast cancer
Lieberthal RD Am J Manag Care 2013 Dec;19(12):1024-31
Managing young colorectal cancer: A UK and Irish perspective
Warrier SK, et al. World J Surg 2014 Feb
Panel-based testing for inherited colorectal cancer: A descriptive study of clinical testing performed by a U.S. Laboratory
Cragun D, et al. Clin Genet 2014 Feb
Patient-reported disease knowledge and educational needs in Lynch syndrome: findings of an interactive multidisciplinary patient conference
Bannon SA, et al. Hered Cancer Clin Pract 2014 Feb;12(1):1
Double mastectomies benefit some breast cancer patients, USA Today, Feb 11
A catalog of cancer genes that’s done, or just a start, Carl Zimmer, New York Times, Feb 6
Expanded DNA testing might allow personalized breast cancer treatment, by Kathleen Doheny, HealthDay, Feb 6
Employer alert: Under GINA, family medical history is genetic information, by Joan Farrell, HR and Employment Law News, Febr 11
23andMe and the FDA
George J. Annas et al . New England Journal of Medicine 2014 Feb 12
Familial clustering of Type 2 diabetes among Omanis
Al-Sinani S, et al. Oman Med J 2014 Jan;29(1):51-4
Providing patient education: impact on quantity and quality of family health history collection
Beadles CA, et al. Fam Cancer 2014 Feb
Family trees, by Chaya Murali, Baylor College of Medicine, Feb 6
Delivery of clinical genetic consultative services in the Veterans Health Administration.
Maren T. Scheuner et al. Genetics in Medicine, Feb 7
Codevelopment of genome-based therapeutics and companion diagnostics
Robert T. McCormack, et al. JAMA 2014 Feb 11
The landscape of genetic variation in dilated cardiomyopathy as surveyed by clinical DNA sequencing.
Trevor J. Pugh et al. Genetics in Medicine, Feb 7
Teaching genomic counseling: Preparing the genetic counseling workforce for the genomic era
Hooker GW, et al. J Genet Couns 2014 Feb
Treatment of homozygous familial hypercholesterolemia
Michael France, et al. Clinical Lipidology February 2014, Vol. 9, No. 1, Pages 101-118
Genetic Alliance launches first pilot program to gather perspectives on benefit-risk assessment in development of new sickle cell disease treatment, by Kristin Van Goor, PhRMA News, Feb 7
Screening for abdominal aortic aneurysm: U.S. Preventive Services Task Force Draft Recommendation Statement, January 2014
Detecting multiple lysosomal storage diseases by tandem mass spectrometry- A National Newborn Screening Program in Taiwan
Liao HC, et al. Clin Chim Acta 2014 Feb
Neonatal screening for cystic fibrosis: Comparing the performances of IRT/DNA and IRT/PAP
Sarles J, et al. J Cyst Fibros 2014 Feb
The path to reading a newborn’s DNA map, The New York Times, Feb 8
Pharmacogenetics in the cancer clinic: from candidate gene studies to next generation sequencing.
Henk-Jan Guchelaar et al. Clin Pharma and Therapeutics, January 2014
Genetic risk factors for major bleeding in warfarin patients in a community setting.
Joshua A. Roth et al, Clin Pharma Therapeutics, February 2014
New method detects genetic defects in egg cells
Tracy Hampton JAMA. 2014;311(5):456.
Accuracy of human papillomavirus testing on self-collected versus clinician-collected samples: a meta-analysis.
Marc Arbyn et al. Lancet Onclogy, Jan 2014
HPV at-home tests have a future, researchers say, by Kathleen Raven, Reuter, Jan 31
Causes and consequences of genetic background effects illuminated by integrative genomic analysis. Chandler CH, Chari S, Tack D, Dworkin I. Genetics Feb 2014
Dense genomic sampling identifies highways of pneumococcal recombination
Claire Chewapreecha et al. Nature Genetics, Feb2014
Genetic variants in C5 and poor response to eculizumab
Jun-ichi Nishimura, et al. N Engl J Med 2014; 370:632-63 2014 Feb 13
Genetic epidemiology and nonsyndromic structural birth defects: From candidate genes to epigenetics
Hobbs CA, et al. JAMA Pediatr 2014 Feb
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium et al. Nature Genetics, February, 2014
The link between genetic variation and variability in vaccine responses: Systematic review and meta-analyses.
Posteraro B, et al. Vaccine. 2014 Feb 7.
The role of religious values in decisions about genetics and the public's health
Modell SM, et al. J Relig Health 2014 Feb
The UK National external quality assessment scheme for heritable bleeding disorders
Perry DJ, et al. Semin Thromb Hemost 2014 Feb
The genetics of major depression.
J Flint et al. Neuron, Feb 2014
Why we should care about what we get for “only $99” from a personal genomic service
Michael F. Murray, MD Annals of Internal Medicine, Feb 11
More on well-posed questions and how to ask them, by Ken Weiss, The Mermaids Tale, Feb 12
Scientific method: Statistical errors, Regina Nuzzo, Nature News, Feb12
Medicine gets up close and personal, by W. Wayt Gibbs, Nature News, Feb 11
The well-posed problem problem, by Anne Buchanan, The Mermaids Tale, Feb 11
There is no such thing as biomedical "Big Data", by Stephen Turner, Getting Genetics Done Blog, Feb 11
Is big data already outpacing health IT? Government Health IT, Feb 11
Free diagnostic exome sequencing for US rare disease patients, Genome Web, Feb 10
Editing the human genome one letter at a time, GEN News Highlights, Feb 10
Genomic testing paves way for personalised medicine, The Herald Sun, Feb 10
I had the bacteria in my gut analysed. and this may be the future of medicine, The Guardian, Feb 8
Multi-tasking DNA: Dual-use codons in the human genome, by Kris A. Wetterstrand, M.S. National Human Genome Research Institute, Feb 6
The gene sequencing future is here, by Beth Mole, Science News, Feb 6
The nation's fastest-growing occupations include genetic counseling (number 9). Carrie Taylor, Houston’s Chronicle, Feb 5
The undiscovered chromosome, Genome Unzipped, Feb 5
Utah poll shows Americans still wary of genetic testing for cancer, The Salt Lake Tribune, Feb 5
Disruptive technologies in medicine: Preparing medical students for the future! By Bertalan Meskó ,Science Roll, Feb 4
Black death left a mark on human genome, by Elizabeth Pennisi, Science Now, Feb 3
Disease gene finding solves international medical mystery, by Glenna Picton,Baylor College of Medicine News, Jan 23
Online aid to assist patient decisions about use of statins
Montori V et al. JAMA, Feb 5
Broad Institute: Welcome to tumorportal genes, cancers, and DNA mutations
CDC authors are indicated in bold
Multiple reassortment events among highly pathogenic avian influenza A(H5N1) viruses detected in Bangladesh.
Gerloff NA, Khan SU, Balish A, Shanta IS, Simpson N, Berman L, Haider N, Poh MK, Islam A, Gurley E, Hasnat MA, Dey T, Shu B, Emery S, Lindstrom S, Haque A, Klimov A, Villanueva J, Rahman M, Azziz-Baumgartner E, Ziaur Rahman M, Luby SP, Zeidner N, Donis RO, Sturm-Ramirez K, Davis CT. Virology. 2014 Feb;450-451:297-307.
De novo assembly of a field isolate genome reveals novel Plasmodium vivax erythrocyte invasion genes
Hester J, Chan ER, Menard D, Mercereau-Puijalon O, Barnwell J, Zimmerman PA, Serre D. PLoS Negl Trop Dis. 2013 Dec;7(12):e2569.
Development of a Genomic DNA Reference Material Panel for Rett Syndrome (MECP2-Related Disorders) Genetic Testing.
Kalman LV, Tarleton JC, Percy AK, Aradhya S, Bale S, Barker SD, Bayrak-Toydemir P, Bridges C, Buller-Burckle AM, Das S, Iyer RK, Vo TD, Zvereff VV, Toji LH. J Mol Diagn. 2014 Feb 1. pii: S1525-1578(13)00258-4.
The CDC Hemophilia B mutation project mutation list: a new online resource.
Li T, Miller CH, Payne AB, Craig Hooper W. Mol Genet Genomic Med. 2013 Nov;1(4):238-45.
Genotypes and virulence characteristics of Shiga toxin-producing Escherichia coli O104 strains from different origins and sources
Miko A, Delannoy S, Fach P, Strockbine NA, Lindstedt BA, Mariani-Kurkdjian P, Reetz J, Beutin L. Int J Med Microbiol. 2013 Dec;303(8):410-21.
A cancer genetics toolkit improves access to genetic services through documentation and use of the family history by primary-care clinicians
Scheuner MT, Hamilton AB, Peredo J, Sale TJ, Austin C, Gilman SC, Bowen MS, Goldzweig CL, Lee M, Mittman BS, Yano EM. Genet Med. 2014 Jan;16(1):60-9.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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