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Genomics & Health Impact Update

Volume 31   Number 13   September 26 - October 3, 2013About the Update


Features of the Week

Middle East Respiratory Syndrome, Genomics & Public Health

Middle East Respiratory Syndrome (MERS)

Middle East Respiratory Syndrome (MERS)? CDC information

Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study.
Cotten M, et al. Lancet. 2013 Sep 19. pii: S0140-6736(13)61887-5.

MERS Co-V genomes reveal complex transmission patterns, Wellcome Trust Sanger Institute, Sep 20

Genomic analysis of MERS coronavirus reveals transmission, by Dr Philippa Brice, PHG Foundation, Sep 23


September Is World Alzheimer's Month

word doodle in a shape of a brain with alzheimer's

CDC information: Learn more about Alzheimer's disease and efforts to address the nation's sixth leading cause of death

World Health Organization report: Dementia as a public health priority

Did you know? 1549 genes have been reported in relation to risk and outcomes of Alzheimer’s disease, including 123 genomewide association studies. Top associated genes include ApoE and MAPT. To find out more, visit the HuGENavigator 

Learn about genetic disorders and genetic testing associated with Alzheimer’s disease from the NIH Genetic Testing Registry


World Heart Day & Familial Hypercholesterolemia

heart puzzle

CDC information: And the beat goes on: Celebrate World Heart Day

CDC information: Heart disease and family history

What is familial hypercholesterolemia? It is a common genetic condition associated with premature heart disease and stroke, FH Foundation information

CDC podcast: Cascade screening in familial hypercholesterolemia

Cascade FH Registry: CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia

FH: A story of hope, video from the FH Foundation

What's the point of genetic testing for FH? PHG Foundation, Sep 26

Family history and screening are keys to treating an inherited disease, Scoop, Sep 19

The British Columbia Familial Hypercholesterolemia Registry
Wong S, et al. BCMJ vo 55 no 7 pg 326-330 2013 Sep


Whole Genome Sequencing in Clinical Practice: Translational Research

Whole Genome Sequencing

NHGRI Division of Genome Medicine plans, directs, funds and facilitates multi-disciplinary research to identify and advance approaches for the use of genomic data to improve diagnosis, treatment and prevention of disease

The MedSeq™ Project: Integration of whole genome sequencing into clinical medicine

CDC paper: Beyond base pairs to bedside: A population approach for using genomics to improve health.
Khoury MJ, et al. Am J Publ Health 2012

CDC paper: The arrival of genomic medicine to the clinic is only the beginning of the journey. [PDF 165.38 KB]
Evans J, et al. Genetics in Medicine, 2013

Communicating genetic risk information for common disorders:  great challenges but also great potential. [PDF 929.26 KB] Lautenbough D, et al. Nature Rev Genetics & Genomics 2013


Antibiotic Resistance, Genomics & Public Health

pills and DNA

CDC report: Antibiotic resistance threats in the United States, 2013 gives a first-ever snapshot of the burden and threats posed by the antibiotic-resistant germs having the most impact on human health.

Untreatable: Report by CDC details today's drug-resistant health threats, CDC Newsroom, Sep 16

When bacteria fight back, Medical Xpress, Sep 23

Genomes reveal roots of TB drug resistance. Tuberculosis strains evolve by gradually acquiring subtle mutations. Ed Yong Nature News, Sep 1

Genomic analysis of superbug provides clues to antibiotic resistance. Science Daily (2011)

The comprehensive antibiotic resistance database.
McArthur AG, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57.

Genomics Research: The underpinning of infectious disease prevention and control strategies. Public Health Genomics special issue (2013)


Type 2 Diabetes Prevention & Family History

a highlighter highlighting the word diabetes

CDC information: Anyone over 45 years should consider getting tested for diabetes, especially if overweight. If you are younger than 45, but are overweight & have a parent, brother or sister w diabetes, you should consider getting tested

CDC fotonovela to learn simple steps to prevent or delay type 2 diabetes, especially if you have a family history of the condition

CDC National Registry of Recognized Diabetes Prevention Programs: Can be used by health care providers to refer patients to a local program; and to also help people who want to make a lifestyle change to prevent type 2 diabetes.


September is Gynecologic Cancers Month

woman talking to doctor after exam

CDC information and educational materials for women and health care providers to raise awareness about the five main gynecologic cancers (cervical, ovarian, uterine, vaginal, and vulvar)

CDC information: Breast and ovarian cancer and family health history

CDC information: Breast and ovarian cancer and genetic testing

CDC information: Genetic counseling and evaluation for BRCA1/2 testing (breast/ovarian cancer)


Hispanic/Latino Heritage Month: Know your Family History

a hispanic family

CDC informatinon:  Learn about the diverse demographic, and link to more information on the health and well-being of Hispanic/Latino Populations in the United States

My Family Health Protrait: A tool from the Surgeon General, collect your family history in Spanish

Diabetes brochure in Spanish: Family history and diabetes-Take steps towards better health!

Genomic health disparities, Type 2 diabetes and Mexican-Americans
Liliana Uribe-Bruce et al. Endoc Reviews (2012)

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Select Events

conference room

Genetics and Primary Care Institute webinar: Integrating Genetics in Your Practice: Overview of Genetic Testing and Screening. Oct 8




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Funding Opportunities

piggy bank on top of a few books

NIH launches new centers to accelerate lab innovations to improve public health, NIH News, Sep 26

New NIH-funded resource focuses on use of genomic variants in medical care, NIH News, Sep 25





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Reports and Publications

Ethics, Policy and Law

Genomics in Practice

a doctor pointing to an item

Actionable, pathogenic incidental findings in 1,000 participants exomes.
Michael O. Dorschner et al, Am J Human Genetics, Sep 19

Hereditary hemochromatosis: Missed diagnosis or misdiagnosis?
Cherfane CE, et al. Am J Med 2013 Sep

Opportunities for genomic clinical decision support interventions.
Casey Lynnette Overby et al, Genetics in Medicine, Sep 19

Predictive genetic testing for complex diseases: a public health perspective
Marzuillo C, et al. QJM 2013 Sep

Guidelines and Recommendations

chess pieces with arrows pointing up

Ensuring the integrity of clinical practice guidelines: a tool for protecting patients
Lenzer J, et al. BMJ. 2013 Sep 17;347:f5535.

Gene expression profiling and expanded immunohistochemistry tests for guiding adjuvant chemotherapy decisions in early breast cancer management: MammaPrint, Oncotype DX, IHC4 and Mammostrat (DG10), NICE, Sep 20

NICE recommends Genomic Health's Oncotype DX® test to guide chemotherapy treatment decisions for qualified early-stage invasive breast cancer patients,Yahoo, Sep 25

Medications for risk reduction of primary breast cancer in women: U.S. Preventive Services Task Force recommendation statement, USPSTF, Sep 24

Recommendations from the EGAPP Working Group: does PCA3 testing for the diagnosis and management of prostate cancer improve patient health outcomes?
Genetics in Medicine 2013 Sep 26

Tuberous sclerosis complex diagnostic criteria update: Recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference
Northrup H, et al. Pediatric Neurology vol 49 iss 4 pg 243-254 2012 Oct

Tuberous sclerosis complex surveillance and management: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference
Krueger D, et al. Pediatric Neurology vol 49 iss 4 pg 255-265 2012 Oct

New guidelines released for diagnosis, surveillance and management of rare genetic disease called tuberous sclerosis complex, Digital Journal, Sep 23

Testing of CYP2C19 variants and platelet reactivity for guiding antiplatelet treatment, AHRQ, Sep 25

Reviews & Commentaries on Science & Technology

Tools and Databases

numbers on a grid

A unified GMDR method for detecting gene–gene interactions in family and unrelated samples with application to nicotine dependence.
Guo-Bo Chen, et al. Human Genetics 2013

The NCI Cancer Genomics and Epidemiology Navigator online searchable database: provides linked information on cancer genomics & epidemiology funding, publications, and genomic tests

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CDC-Authored Genomics Publications


CDC authors are indicated in bold

Collaborative cancer epidemiology in the 21st century: the model of cancer consortia.
Burgio MR Jr, Ioannidis JP, Kaminski BM, Derycke E, Rogers S, Khoury MJ, Seminara D.
Cancer Epidemiol Biomarkers Prev. 2013 Sep 19.

Factors affecting maternal participation in the genetic component of the National Birth Defects Prevention Study—United States, 1997–2007
Jill Glidewell MSN, MPH, Jennita Reefhuis PhD, Sonja A. Rasmussen MD, MS, Alison Woomert PhD, Charlotte Hobbs MD, PhD, Paul A. Romitti PhD & Krista S. Crider PhD

Application of real time RT-PCR for the genetic homogeneity and stability tests of the seed candidates for live attenuated influenza vaccine production.
Shcherbik S, Sergent SB, Davis WG, Shu B, Barnes J, Kiseleva I, Larionova N, Klimov A, Bousse T. J Virol Methods. 2013 Sep 18.

Genetic testing strategies in newly diagnosed endometrial cancer patients aimed at reducing morbidity or mortality from Lynch syndrome in the index case or her relatives.
Stewart A Phd. PLoS Curr. 2013 Sep 16;5.

View previous CDC-authored publications

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About the Genomics & Health Impact Update

The Update includes  genomics and health impact news and publications, CDC announcements, reports, blogs, podcasts, and other products. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science.  To receive the update electronically every week sign-up here.


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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.


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