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Genomics & Health Impact Update

Volume 31   Number 1   July 3 - July 11, 2013

Spotlight: Why We Can't Wait: Health Disparities in Genomic Medicine

minorities with the American flag in the background

New CDC blog post: Why we can’t wait? A public health approach to disparities in genomic medicine

Why we can’t wait: 2013 Conference to eliminate health disparities in genomic medicine

CDC feature: Breast cancer disparities

CDC Health Equity Matters Newsletter

Features of the Week

Public Health Genomics Implementation- Clickable State Map

US Map

CDC clickable state public health genomic map on implementation of three Tier I genomic applications: Hereditary breast / ovarian cancer, Lynch syndrome and familial hypercholesterolemia.

New CDC blog post: A public health genomic state-by-state clickable map: Accelerating implementation of genomics applications to improve population health

CDC information: Public health action is now needed beyond newborn screening

CDC blog post: Implementing evidence-based genomics recommendations at the intersection of public health and healthcare


This July 4th, Gain Freedom From Tobacco Use: Genetics & Tobacco Addiction

hands breaking a cigarette with fireworks in the backgroundCDC information: Tobacco products are designed for addiction-psychosocial, biologic, and genetic factors play a role in tobacco addiction.

Genetics vs. tobacco taxes: The limits of public policy aimed at reducing smoking - study by Robert Wood Johnson Foundation scholar finds that genes may help explain why some people will pay more to satisfy their smoking habits, Dec 2012

CDC blog post on smoking and genomics: Where there is smoke there is fire… addiction, and yet desire to quit (2012)

Did you know? More than 5000 genes have been reported in relation to smoking health risks and addiction including 89 genomewide association studies. To find out more, visit the HuGE Navigator


Family Reunions and Family Health History

family picnicCDC feature: Have a healthy and safe family reunion-know and share your family health history

CDC information: Why is family history important to your health?

Collect your family health history and share it with your provider,a tool from the US Surgeon General



Whole Genome Sequencing in Healthy People?

healthy people running with genome sequencing in backgroundWhole genome sequencing in support of wellness and health maintenance. [PDF 262.34 KB]
Patel C et al. Genome Medicine, June 2013

Whole genome sequencing and you, Mount Sinai School of Medicine Video (2012)

Should we sequence everyone's genome? No.
Frances Flinter BMJ 2013;346:f3132

Should we sequence everyone's genome? Yes.
John Burn BMJ 2013;346:f3133

Commentary: We screen newborns, don't we? Realizing the promise of public health genomics. James P. Evans et al. Genetics in Medicine, Mar 7

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Diseases of the Week


mother with daughter at picnic

CDC information on asthma
Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study.
Belsky DW et al. Lancet Respiratory Medicine June 2013

Prospects for genetic susceptibility test for asthma, by Dr Philippa Brice, PHG Foundation, Jul 1

Asthma in the real world.
Obyrne PM.  J Allergy Clin Immunology March 2013

Asthma genetic risk research could lead to future test, BBC News, Jun 27

Did you know? Genetic tests are available for 27 asthma-related conditions. To find out more, consult the Genetic Testing Registry

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Select Events

conference room

Integrative Molecular Epidemiology, American Association for Cancer Research, July 15-20, 2013,  Boston, Mass

Dive into the Gene Pool: Integrating genetics and genomics into your pediatric primary care practice, August 9-10, 2013, Chicago, Illinois

Translational Research in Genomic Medicine: What can genomic medicine offer today? How can genomics improve screening and prevention of disease? Emory University-CDC Course, Atlanta, Georgia August 15-16, 2013.

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Funding Opportunities

piggy bank on top of a few books

New NHGRI grants focus on using genomic information in patient care

Projects center on the use of family health histories, gene variants associated with kidney disease in African Americans and pharmacogenomics, by Steven Benowitz, National Human Genome Research Institute, Jul 1


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Reports and Publications

stacked journals


BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch Syndrome. 
Toon CW et al. Am J Surg Pathol, Jun 2013

The impact of the 21-gene recurrence score assay on clinical decision-making in node-positive (up to 3 positive nodes) estrogen receptor-positive breast cancer patients
Stemmer SM, et al. Breast Cancer Res Treat 2013 Jun

Familial breast cancer: classification and care of people at risk of familial breast cancer and management of breast cancer and related risks in people with a family history of breast cancer, NICE


Ethics, Policy and Law

Understanding of informed consent by parents of children enrolled in a genetic biobank
Jennifer Klima et al. Genetics in Medicine, June 27

Researchers’ views on return of incidental genomic research results: qualitative and quantitative findings.
Robert Klitzman et al. Genetics in Medicine, June 27

A culture of consent, Nature Editorial, Jun 26

Privacy and our genes: Is deCode’s DNA project ‘Big Brother’ or the gateway to a healthier future? Rebecca Goldin, Genetic Literacy Project, Jun 24


Family History

Family history and its association to curve size and treatment in 1,463 patients with idiopathic scoliosis
Grauers A, et al. Eur Spine J 2013 Jun

Prognostic impact of family history in southern Chinese patients with undifferentiated nasopharyngeal carcinoma
Ouyang PY, et al. Br J Cancer 2013 Jun

Self-reported family history in estimating the risk of hormone, surgery and cast related VTE in women
Sonnevi K, et al. Thromb Res 2013 Jun


Genomics in Practice

A dedicated colorectal cancer genetics service improves adherence with molecular testing for Lynch syndrome.
Stevens S et al. Gut 2013;62:A200 doi:10.1136/gutjnl-2013-304907.458

Rationalized DNA sequencing-based protocol for genotyping patients receiving coumarin therapy
Rakicevic LB, et al. Scand J Clin Lab Invest 2013 Jun

Whole genome sequencing in support of wellness and health maintenance
Patel CJ, et al. Genome Med 2013 Jun;5(6):58


Genomic Tests

Advancing genetic testing for deafness with genomic technology
Shearer AE, et al. J Med Genet 2013 Jun

Exome sequencing resolves apparent incidental findings and reveals further complexity of SH3TC2 variant alleles causing Charcot-Marie-Tooth neuropathy
James R Lupski, et al Genome Medicine, June 2013

Five reasons NOT to do genetic testing, Medscape, Jun 27 [by free subscription only]


Guidelines and Recommendations

Centers for Disease Control and Prevention. Can molecular testing indicate optimal treatment in metastatic colorectal cancer? Medscape. Jul 1[by free subscription only]

Familial breast cancer: summary of updated NICE guidance
Evans DG BMJ2013;346:f3829, 2013 Jun 25


Newborn Screening

Maternal attitudes and knowledge about newborn screening
Newcomb P, et al. MCN Am J Matern Child Nurs 2013 Jun


Public Health Sciences

Development of an economic evaluation of diagnostic strategies: the case of monogenic diabetes
Peters JL, et al. BMJ Open 2013;3(5)

Changes in cystic fibrosis airway microbiota at pulmonary exacerbation
Carmody L, Zhao J, Schloss P, et al. Annals of the American Thoracic Society, Vol. 10, No. 3 (2013), pp. 179-187.

Genome-wide association study identifies vitamin B5 biosynthesis as a host specificity factor in Campylobacter
Samuel K. Sheppard et al. PNAS, Jun 2013

Variations in predicted risks in personal genome testing for common complex diseases.
Rachel R.J. Kalf et al. Genetics in Medicine, Jun 27


Reviews and Commentaries on Science & Technology

The benefits of biobanks: Vast stores of tissue, immense resources to understand disease, by Courtney Humphries, Spring 2013

Recent advances in Parkinson’s disease genetics, European Parkinson Disease Association, Jun 2013

Understanding autism through genetics, Michael J. Dougherty, ActionBiosciences.Org, Jun 2013

Child abuse leaves genetic marks, NHGRI, Jul 2

Cancer and the microbiome: A punch in the gut- how microbes promote liver cancer in the overweight, The Economist, Jun 29

The meaning of “genome”, Wellcome Trust, Jun 28

Why do docs struggle with population health data? Brino A, Government Health IT, Jun 28

Eric Topol asks Kathleen Sebelius 5 ACA questions, Medscape, Jun 27
Q5: The future of medicine is all about genetic testing and using genetic data to develop new and better treatments for patients. How does genomic medicine figure into the ACA? How is it helping to further personalized medicine for patients?

Genome vs. exome: Which works best? Baylor College of Medicine, Jun 27

The DNA data deluge: Fast, efficient genome sequencing machines are spewing out more data than geneticists can analyze, by Michael C. Schatz & Ben Langmead, IEEE Spectrum, Jun 27

Studying tumors differently, in hopes of outsmarting them, by Carl Zimmer, New York Times, Jun 27

Clinical next-generation sequencing to guide cancer treatment decisions, OncLive, Jun 26

Genetic testing, Huffington Post, Jun 26

The cancer genome in context: of mice and mutations
Sequencing the genomes of cancer cells lets us identify the mutations that drive the disease, the Guardian, Jun 25


Tools and Databases

National Center for Biotechnology Information ClinVar Database aggregates information about sequence variation and its relationship to human health

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CDC-Authored Genomics Publications


CDC authors are indicated in bold

Can molecular testing indicate optimal treatment in metastatic colorectal cancer?
Office of Public Health Genomics, Centers for Disease Control and Prevention, CDC Expert Commentary, Medscape, 2013 Jul 1

Human G9P[8] rotavirus strains circulating in Cameroon, 1999-2000: genetic relationships with other G9 strains and detection of a new G9 subtype
Esona MD, Mijatovic-Rustempasic S, Foytich K, Roy S, Banyai K, Armah G, Steele A, Volotao E, Gomez M, Silva M, Gautam R, Quaye O, Tam K, Forbi J, Seheri M, Page N, Nyangao J, Ndze V, Aminu M, Bowen M, Gentsch J. Infect Genet Evol. 2013 Jun 13.

Antimicrobial resistance genes in multidrug-resistant Salmonella enterica isolated from animals, retail meats, and humans in the United States and Canada
Glenn LM, Lindsey RL, Folster JP, Pecic G, Boerlin P, Gilmour MW, Harbottle H, Zhao S, McDermott PF, Fedorka-Cray PJ, Frye JG. Microb Drug Resist. 2013 Jun;19(3):175-84.

Prevalence, characteristics and clinical diagnosis of maturity onset diabetes of the young due to mutations in HNF1A, HNF4A, and glucokinase: results from the SEARCH for Diabetes in Youth
Gilliam LK, Pihoker C, Ellard S, Hattersley AT, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE. J Clin Endocrinol Metab. 2013 Jun 14.

Plasmodium vivax merozoite surface protein-3 (PvMSP3): expression of an 11 member multigene family in blood-stage parasites
Jiang J, Barnwell JW, Meyer EV, Galinski MR. PLoS One. 2013 ;8(5):e63888.

View previous CDC-authored publications

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About the Genomics & Health Impact Update

The Update includes  genomics and health impact news and publications, CDC announcements, reports, blogs, podcasts, and other products. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science.  To receive the update electronically every week sign-up here.


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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.


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