Genomics & Health Impact Update
Volume 31 Number 1 July 3 - July 11, 2013
CDC feature: Breast cancer disparities
CDC information: Public health action is now needed beyond newborn screening
Genetics vs. tobacco taxes: The limits of public policy aimed at reducing smoking - study by Robert Wood Johnson Foundation scholar finds that genes may help explain why some people will pay more to satisfy their smoking habits, Dec 2012
CDC blog post on smoking and genomics: Where there is smoke there is fire… addiction, and yet desire to quit (2012)
Did you know? More than 5000 genes have been reported in relation to smoking health risks and addiction including 89 genomewide association studies. To find out more, visit the HuGE Navigator
Family Reunions and Family Health History
CDC information: Why is family history important to your health?
Collect your family health history and share it with your provider,a tool from the US Surgeon General
Whole Genome Sequencing in Healthy People?
Whole genome sequencing in support of wellness and health maintenance. [PDF 262.34 KB]
Patel C et al. Genome Medicine, June 2013
Whole genome sequencing and you, Mount Sinai School of Medicine Video (2012)
Should we sequence everyone's genome? No.
Frances Flinter BMJ 2013;346:f3132
Should we sequence everyone's genome? Yes.
John Burn BMJ 2013;346:f3133
Commentary: We screen newborns, don't we? Realizing the promise of public health genomics. James P. Evans et al. Genetics in Medicine, Mar 7
CDC information on asthma
Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study.
Belsky DW et al. Lancet Respiratory Medicine June 2013
Prospects for genetic susceptibility test for asthma, by Dr Philippa Brice, PHG Foundation, Jul 1
Asthma in the real world.
Obyrne PM. J Allergy Clin Immunology March 2013
Asthma genetic risk research could lead to future test, BBC News, Jun 27
Did you know? Genetic tests are available for 27 asthma-related conditions. To find out more, consult the Genetic Testing Registry
Integrative Molecular Epidemiology, American Association for Cancer Research, July 15-20, 2013, Boston, Mass
Dive into the Gene Pool: Integrating genetics and genomics into your pediatric primary care practice, August 9-10, 2013, Chicago, Illinois
Translational Research in Genomic Medicine: What can genomic medicine offer today? How can genomics improve screening and prevention of disease? Emory University-CDC Course, Atlanta, Georgia August 15-16, 2013.
Projects center on the use of family health histories, gene variants associated with kidney disease in African Americans and pharmacogenomics, by Steven Benowitz, National Human Genome Research Institute, Jul 1
BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch Syndrome.
Toon CW et al. Am J Surg Pathol, Jun 2013
The impact of the 21-gene recurrence score assay on clinical decision-making in node-positive (up to 3 positive nodes) estrogen receptor-positive breast cancer patients
Stemmer SM, et al. Breast Cancer Res Treat 2013 Jun
Ethics, Policy and Law
Understanding of informed consent by parents of children enrolled in a genetic biobank
Jennifer Klima et al. Genetics in Medicine, June 27
Researchers’ views on return of incidental genomic research results: qualitative and quantitative findings.
Robert Klitzman et al. Genetics in Medicine, June 27
A culture of consent, Nature Editorial, Jun 26
Privacy and our genes: Is deCode’s DNA project ‘Big Brother’ or the gateway to a healthier future? Rebecca Goldin, Genetic Literacy Project, Jun 24
Family history and its association to curve size and treatment in 1,463 patients with idiopathic scoliosis
Grauers A, et al. Eur Spine J 2013 Jun
Prognostic impact of family history in southern Chinese patients with undifferentiated nasopharyngeal carcinoma
Ouyang PY, et al. Br J Cancer 2013 Jun
Self-reported family history in estimating the risk of hormone, surgery and cast related VTE in women
Sonnevi K, et al. Thromb Res 2013 Jun
Genomics in Practice
A dedicated colorectal cancer genetics service improves adherence with molecular testing for Lynch syndrome.
Stevens S et al. Gut 2013;62:A200 doi:10.1136/gutjnl-2013-304907.458
Rationalized DNA sequencing-based protocol for genotyping patients receiving coumarin therapy
Rakicevic LB, et al. Scand J Clin Lab Invest 2013 Jun
Whole genome sequencing in support of wellness and health maintenance
Patel CJ, et al. Genome Med 2013 Jun;5(6):58
Advancing genetic testing for deafness with genomic technology
Shearer AE, et al. J Med Genet 2013 Jun
Exome sequencing resolves apparent incidental findings and reveals further complexity of SH3TC2 variant alleles causing Charcot-Marie-Tooth neuropathy
James R Lupski, et al Genome Medicine, June 2013
Five reasons NOT to do genetic testing, Medscape, Jun 27 [by free subscription only]
Guidelines and Recommendations
Centers for Disease Control and Prevention. Can molecular testing indicate optimal treatment in metastatic colorectal cancer? Medscape. Jul 1[by free subscription only]
Familial breast cancer: summary of updated NICE guidance
Evans DG BMJ2013;346:f3829, 2013 Jun 25
Maternal attitudes and knowledge about newborn screening
Newcomb P, et al. MCN Am J Matern Child Nurs 2013 Jun
Public Health Sciences
Development of an economic evaluation of diagnostic strategies: the case of monogenic diabetes
Peters JL, et al. BMJ Open 2013;3(5)
Changes in cystic fibrosis airway microbiota at pulmonary exacerbation
Carmody L, Zhao J, Schloss P, et al. Annals of the American Thoracic Society, Vol. 10, No. 3 (2013), pp. 179-187.
Genome-wide association study identifies vitamin B5 biosynthesis as a host specificity factor in Campylobacter
Samuel K. Sheppard et al. PNAS, Jun 2013
Variations in predicted risks in personal genome testing for common complex diseases.
Rachel R.J. Kalf et al. Genetics in Medicine, Jun 27
Reviews and Commentaries on Science & Technology
The benefits of biobanks: Vast stores of tissue, immense resources to understand disease, by Courtney Humphries, Spring 2013
Recent advances in Parkinson’s disease genetics, European Parkinson Disease Association, Jun 2013
Understanding autism through genetics, Michael J. Dougherty, ActionBiosciences.Org, Jun 2013
Child abuse leaves genetic marks, NHGRI, Jul 2
Cancer and the microbiome: A punch in the gut- how microbes promote liver cancer in the overweight, The Economist, Jun 29
The meaning of “genome”, Wellcome Trust, Jun 28
Why do docs struggle with population health data? Brino A, Government Health IT, Jun 28
Eric Topol asks Kathleen Sebelius 5 ACA questions, Medscape, Jun 27
Q5: The future of medicine is all about genetic testing and using genetic data to develop new and better treatments for patients. How does genomic medicine figure into the ACA? How is it helping to further personalized medicine for patients?
Genome vs. exome: Which works best? Baylor College of Medicine, Jun 27
The DNA data deluge: Fast, efficient genome sequencing machines are spewing out more data than geneticists can analyze, by Michael C. Schatz & Ben Langmead, IEEE Spectrum, Jun 27
Studying tumors differently, in hopes of outsmarting them, by Carl Zimmer, New York Times, Jun 27
Genetic testing, Huffington Post, Jun 26
The cancer genome in context: of mice and mutations
Sequencing the genomes of cancer cells lets us identify the mutations that drive the disease, the Guardian, Jun 25
Tools and Databases
CDC authors are indicated in bold
Can molecular testing indicate optimal treatment in metastatic colorectal cancer?
Office of Public Health Genomics, Centers for Disease Control and Prevention, CDC Expert Commentary, Medscape, 2013 Jul 1
Human G9P rotavirus strains circulating in Cameroon, 1999-2000: genetic relationships with other G9 strains and detection of a new G9 subtype
Esona MD, Mijatovic-Rustempasic S, Foytich K, Roy S, Banyai K, Armah G, Steele A, Volotao E, Gomez M, Silva M, Gautam R, Quaye O, Tam K, Forbi J, Seheri M, Page N, Nyangao J, Ndze V, Aminu M, Bowen M, Gentsch J. Infect Genet Evol. 2013 Jun 13.
Antimicrobial resistance genes in multidrug-resistant Salmonella enterica isolated from animals, retail meats, and humans in the United States and Canada
Glenn LM, Lindsey RL, Folster JP, Pecic G, Boerlin P, Gilmour MW, Harbottle H, Zhao S, McDermott PF, Fedorka-Cray PJ, Frye JG. Microb Drug Resist. 2013 Jun;19(3):175-84.
Prevalence, characteristics and clinical diagnosis of maturity onset diabetes of the young due to mutations in HNF1A, HNF4A, and glucokinase: results from the SEARCH for Diabetes in Youth
Gilliam LK, Pihoker C, Ellard S, Hattersley AT, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE. J Clin Endocrinol Metab. 2013 Jun 14.
Plasmodium vivax merozoite surface protein-3 (PvMSP3): expression of an 11 member multigene family in blood-stage parasites
Jiang J, Barnwell JW, Meyer EV, Galinski MR. PLoS One. 2013 ;8(5):e63888.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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