Genomics & Health Impact Update
Volume 31 Number 24 December 19-24, 2013About the Update
Contents of the week
- Family History & the Holidays
- Pathogen Genomics & Public Health
- The Microbiome in Health & Disease
- Genomics Translation: The Road Less Traveled
- Genome Sequencing in the Clinic
- Heart Disease & Genomics
- Diabetes Prevention, Family History & Genomics
- Lynch Syndrome Universal Screening
- Health Disparities & Genomics
Assessing Genomic Sequencing Information for Health Care Decision Making: A Workshop
Institute of Medicine's Roundtable on Translating Genomic-Based Research for Health
February 3 ~ Washington, DC
Cancer Epigenetics (Q1)
February 4-9 ~ Santa Fe, NM
Genomic Disorders 2014: The Genomics of Rare Diseases
March 5-7 ~ Cambridge, UK
NIH seeks funding applications for data coordination and integration center, Genome Web, Dec 13 [by free subscription only]
Consortium launches genotyping effort
Cancer Discov 2013 Dec;3(12):1321-2
Network formed to discover new cancer susceptibility variants, NCI Cancer Epidemiology Matters News, Dec 2013
Do BRCA1 and BRCA2 mutation carriers have earlier natural menopause than their noncarrier relatives? Results from the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer.
Collins IM, et al. J Clin Oncol. 2013 Nov 1;31(31):3920-5.
Identifying potential cancer driver genes by genomic data integration
Yong Chen et al. Nature, 2013 Dec 18
Optimizing recruitment to a prostate cancer surveillance program among male BRCA1 mutation carriers: invitation by mail or by telephone
Galor A, et al. Hered Cancer Clin Pract 2013 Dec;11(1):17
In BRCA, tamoxifen may reduce contralateral breast cancer risk, Clinical Oncology, Dec 2013
Anticipate and Communicate: Ethical management of incidental and secondary findings in the clinical, research, and direct-to-consumer contexts, [PDF 1.73 MB] Presidential Commission for the Study of Bioethical Issues, Dec 2013
US Bioethics Commission report on incidental findings, PHG Foundation, Dec 17
The Bioethics Commission on Incidental Findings
Amy Gutmann, Science, December 13
Medics should plan ahead for incidental findings- US bioethics commission weighs in on debate over how scientists and companies should handle inadvertent discoveries in diagnostic tests.
Erika Check Hayden, Nature Dec 12
ELSI* and the implemention of WGS / WES in clinical practice, PHG Foundation, Dec 17
David vs Goliath. But who is who? Stephan Struve, Genome Alberta, Dec 3
Family history of premature cardiovascular disease: blood pressure control and long-term mortality outcomes in hypertensive patients
Williamson C, et al. Eur Heart J. 2013 Dec 15.
Genetic testing may help direct treatment in epilepsy, Medscape, Dec 17 [by free subscription only]
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Ariey F, et al. Nature 2013 Dec 18
Meta-analysis of gene-level tests for rare variant association
Liu D, et al. Nature Genetics 2013 Dec 15
New genetic analysis method holds promise for understanding causes of disease, Medical Xpress, Dec 17
Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis
Bon L,et al. New Engl J of Med 2013 Dec 18
Resistance gene identified in malaria parasite, by Ewen Callaway, Nature, Dec 18
The emerging agenda of stratified medicine in neurology.
Paul M. Matthews Nature Reviews Neurology, Dec 10
Post-GWAS: where next? More samples, more SNPs or more biology? P Marjoram et al. Heredity, Jan 2014
365 days: 2013 in review, Nature News, Dec 18
European bioinformatics infrastructure ELIXIR launched, by Philippa Brice, PHG Foundation, Dec 18
The start of a journey, Ewan's Blog-Bioinformatician at large, Dec 17
Realising genomics in clinical practice, PHG Foundation, Dec 17
Smoking changes our genes, Uppsala University, Dec 17
Author post: Joint analysis of functional genomic data and genome-wide association studies of 18 human traits, Joe Pickrell, Haldane’s Sieve, Dec 16
Dual 'hidden' meaning within DNA code discovered, by Philippa Brice PHG Foundation, Dec 16
Harvard geneticist George Church on genome testing: “I wouldn’t wait. I didn’t wait.” By Callum Borchers, Boston Globe, Dec 13
Charting the RNA epigenome, Leah Eisenstadt, Broad Institute Blog, Dec 13
Education in Computational Biology Today and Tomorrow, PloS Computational Biology, Dec 13
Utah Genome Project aims to sequence several thousand individuals from variety of disease cohorts, Genome Web, Dec 11 [by free subscription only]
CDC authors are indicated in bold
Recommendations for returning genomic incidental findings? We need to talk!
Burke W, Matheny Antommaria AH, Bennett R, Botkin J, Clayton EW, Henderson GE, Holm IA, et al. Genet Med. 2013 Nov;15(11):854-9.
Identification of vaccine-derived polioviruses using dual-stage real-time RT-PCR.
Kilpatrick DR, Ching K, Iber J, Chen Q, Yang SJ, De L, Williams AJ, Mandelbaum M, Sun H, Oberste MS, Kew OM. J Virol Methods. 2013 Dec 6.
Personal history of diabetes, genetic susceptibility to diabetes, and risk of brain glioma: a pooled analysis of observational studies
Kitahara CM, Linet M, Brenner AV, Wang SS, Melin B, Wang Z, Inskip PD, Beane Freeman L, Braganza MZ, Carreon T, Feychting M, Gaziano JM, Peters U, Purdue MP, Ruder A, Sesso HD, Shu XO, Waters M, White E, Zheng W, Hoover RN, Fraumeni JF, Chatterjee N, Yeager M, Chanock SJ, Hartge P, Rajaraman P. Cancer Epidemiol Biomarkers Prev. 2013 Nov 12.
Epigenetic research in cancer epidemiology: Trends, opportunities, and challenges.
Verma M, Rogers S, Divi RL, Schully SD, Nelson S, Su LJ, Ross S, Pilch S, Winn DM, Khoury MJ. Cancer Epidemiol Biomarkers Prev. 2013 Dec 10
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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