Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science. To receive this update electronically every week sign-up here.
Thursday, October 11, 2012 Volume 29 Number 15
- Fighting Outbreaks with Bacterial Genomics: Case Review and Workflow Proposal.
Cheung MK, Kwan HS. Public Health Genomics. 2012 Oct 3
- Outbreak of Mycobacterium mucogenicum Bloodstream Infections among Patients with Sickle Cell Disease in an Outpatient Setting.
Ashraf MS, Swinker M, Augustino KL, et al. Infect Control Hosp Epidemiol. 2012 Nov;33(11):1132-6.
- Genotyping helps identify source of clinic infection outbreak, Science Daily, October 5
- CDC Blog: Genomic Epidemiology
- Current CDC outbreak public health investigations: meningitis, salmonella, hantavirus & more
- CDC multistate meningitis outbreak investigation
- CDC report: What is the role of human genomics in acute public health investigations? (2005)
- CDC study: Genetic studies of infectious disease susceptibility on the rise but remain a relatively small field
- 4th Annual Consumer Genetics Conference, October 3-5, 2012
- New York Genome Center: The future of consumer genetics
- Twitter archive of Consumer Genetics Conference
- CDC blog: on DTC genomics: clinical actionability will be unknown for quite some time-more data needed
- CDC survey-DTC genomics: increased consumer awareness calls for education, policy development & surveillance
- CDC paper: danger of reverse genetic exceptionalism: what happens if we give genetic info a pass from rules of evidence?
New Strategies in Public Health Genomics Beyond Newborn Screening
- New CDC Blog: New Strategies in Public Health Genomics Beyond Newborn Screening: Working meeting and action plan to save lives now
- New CDC article: Public Health Action in Genomics Is Now Needed beyond Newborn Screening
Bowen MS, Kolor K, Dotson WD, et al. Public Health Genomics 2012 Sept 11
- Updated Evidence based Table: Genomic Tests and Family History by Levels of Evidence
Genomic Medicine Infrastructure: Training and Electronic Health Records
- A first: a medical school course on practical analysis of personal whole genome sequence
- A first: combined MD-MS Program in Genomic Medicine
- Training clinicians AND public health professionals is crucial for the success of genomics in improving health, Secretary’s Advisory Committee on Genetics, Health and Society 2011 report and recommendations [PDF 2.55 MB]
- CDC Genomic competencies for the Public Health Workforce, a decade later
- A genome-enabled electronic health record is crucial for translating complex genomic information in clinical practice
- CDC Report: Data on physician adoption of electronic health record systems in the US, 2011
October is Breast Cancer Awareness Month
- CDC feature: Learn what factors can increase your chance of getting breast cancer
- CDC feature: Learn how family history increases risk of getting breast cancer
- CDC information: Genetic testing for breast/ovarian cancer
- Watch CDC podcast on genetic testing for breast/ovarian cancer
- CDC/California Study: Women with a family history of breast/ovarian cancer more likely to be up to date with mammography
October is Sudden Infant Death Syndrome Awareness Month
- There is limited literature on genetics of SIDS: Since 2001, 65 genetic association studies have been conducted with no meta analyses or genome wide association studies-Check out the HuGE Navigator
Getting our priorities straight: a novel framework for stakeholder-informed prioritization of cancer genomics researchEsmail LC, et al. Genet Med 2012 Oct
A whole-blood RNA transcript-based prognostic model in men with castration-resistant prostate cancer: a prospective study
Ross R, Galsky M, Scher H, et al. The Lancet Oncology, Early Online Publication, 9 October 2012. doi:10.1016/S1470-2045(12)70263-2
- Prostate cancer genetic 'signatures' could predict who will have aggressive tumors, The Huffington Post, October 8
Exploiting FOXM1-Orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis.
Teh MT, Hutchison IL, Costea DE, et al. Int J Cancer. 2012 Oct 4.
- Early mouth cancer risk detected by new gene test, Medical News Today, October 8
- Prevalence and Phenotypes of APC and MUTYH Mutations in Patients With Multiple Colorectal Adenomas
Grover S, Kastrinos F, Steyerberg EW, et al JAMA. 2012;308:485-492
- Squaring genetic vs clinical findings in familial polyposis, Medscape, October 4 [by free subscription only]
Genomics in Practice
Communicating inherited genetic risk between parent and child: A meta-thematic synthesis
Rowland E & Metcalfe A Int J Nurs Stud 2012 Sep
Clinical utility gene card for: familial polycythaemia vera
Hussein K, et al. Eur J Hum Genet 2012 Oct
Including the initial newborn screening bloodspot collection device serial number on birth certificates: basis and recommendations from the Secretary of Health and Human Services' Advisory Committee on Heritable Disorders in Newborns and Children
Therrell BL & Wu C Genet Med 2012 Oct
Rapid whole-genome sequencing for genetic disease diagnosis in neonatal intensive care units.
Saunders CJ, Miller NA, Soden SE, et al. Sci Transl Med. 2012 Oct 3;4(154):154ra135
- Infant DNA tests speed diagnosis of rare diseases, The New York Times, October 3
- Privacy and Progress in Whole Genome Sequencing, Presidential Commision for the Study of Bioethical Issues
- US ethics panel reports on DNA sequencing and privacy, Nature News Blog, October 11
Public Health Sciences
The Public Health and Policy Implications of Epigenetics and Pediatric Health Research
Witherspoon NO, et al. Environ Health Perspect 2012 Oct;120(10):a380-a381
Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children
Wagner J & Leeder JS Pediatr Clin North Am 2012 Oct;59(5):1017-37
Genetics of infections, Genome Web, October [by free subscription only]
CDC authors are indicated in bold
Survey and genetic characterization of wastewater in Tunisia for Cryptosporidium spp., Giardia duodenalis, Enterocytozoon bieneusi, Cyclospora cayetanensis and Eimeria spp
Ben Ayed L, Yang W, Widmer G, Cama V, Ortega Y, Xiao L. J Water Health. 2012 Sep;10(3):431-44.
Genome sequences for six Rhodanobacter strains, isolated from soils and the terrestrial subsurface, with variable denitrification capabilities
Kostka JE, Green SJ, Rishishwar L, Prakash O, Katz LS, Marino-Ramirez L, Jordan IK, Munk C, Ivanova N, Mikhailova N, Watson DB, Brown SD, Palumbo AV, Brooks SC. J Bacteriol. 2012 Aug;194(16):4461-2.
Personalized medicine in major depressive disorder - opportunities and pitfalls
Miller DB, O'Callaghan JP. Metabolism. 2012 Sep 25.
Association of nucleotide polymorphisms within the O-antigen gene cluster of Escherichia coli O26, O45, O103, O111, O121, and O145 with serogroups and genetic subtypes
Norman KN, Strockbine NA, Bono JL. Appl Environ Microbiol. 2012 Sep;78(18):6689-703.
Health behaviors and cancer screening among Californians with a family history of cancer
Townsend JS, Steele CB, Richardson LC, Stewart SL. Genet Med. 2012 Sep 27.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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