Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science. To receive this update electronically every week sign-up here.
Wednesday, October 3, 2012 Volume 29 Number 14
New Strategies in Public Health Genomics Beyond Newborn Screening
- New CDC Blog: New Strategies in Public Health Genomics Beyond Newborn Screening: Working meeting and action plan to save lives now
- New CDC article: Public Health Action in Genomics Is Now Needed beyond Newborn Screening
Bowen MS, Kolor K, Dotson WD, et al. Public Health Genomics 2012 Sept 11
- Updated Evidence based Table: Genomic Tests and Family History by Levels of Evidence
Family History and Evidence-based Disease Prevention
- New CDC Podcast: Family Health History: Use It to Inform Preventive Services for Your Patients
- New CDC Blog: Evidence Matters in Genomic Medicine—Round 3: Integrating Family Health History into Clinical Preventive Services
- CDC Family history initiative & recent publications from the Family Healthware Intervention Trial (FHiTr)
October is Breast Cancer Awareness Month
- CDC feature: Learn what factors can increase your chance of getting breast cancer
- CDC feature: Learn how family history increases risk of getting breast cancer
- CDC information: Genetic testing for breast/ovarian cancer
- Watch CDC podcast on genetic testing for breast/ovarian cancer
- CDC/California Study: Women with a family history of breast/ovarian cancer more likely to be up to date with mammography
October is Sudden Infant Death Syndrome Awareness Month
- There is limited literature on genetics of SIDS: Since 2001, 65 genetic association studies have been conducted with no meta analyses or genome wide association studies-Check out the HuGE Navigator
CDC Feature: Depression
- Treatment Works: Get Help for Depression and Anxiety
- US Preventive Services Task Force recommended in 2009 screening of adolescents (12-18 years of age) for major depressive disorder when systems are in place to ensure accurate diagnosis, psychotherapy and follow-up
- Tier 2 application: The USPSTF identified parental depression as one of several important risk factors that can be assessed relatively accurately and reliably when screening adolescents for major depressive disorder
- Since 2001, 963 publications have examined 401 genes in relation to risk of depression, including 31 genomewide association studies and 46 meta analyses. To find out more about genes associated with depression, visit the HuGE Navigator
Breast cancer incidence after risk-reducing salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers
Fakkert IE, et al. Cancer Prev Res (Phila) 2012 Sep
Health behaviors and cancer screening among Californians with a family history of cancer
Townsend JS, et al. Genet Med 2012 Sep
Genomics in Practice
- Leveraging the electronic health record to implement genomic medicine
Kullo IJ, et al. Genet Med 2012 Sep
Clinical utility gene card for: osteogenesis imperfecta
van Dijk FS, et al. Eur J Hum Genet 2012 Sep
- Food and Drug Administration Approval of Cetuximab and a New KRAS Genetic Test for Metastatic Colorectal Cancer: Major Advance but Just the Tip of the Biomarker Iceberg
Lieberman R Am J Ther 2012 Sep
- Economic Evaluations Conducted for Assessment of Genetic Testing Technologies: A Systematic Review
Assasi N, et al. Genet Test Mol Biomarkers 2012 Sep
Guidelines and Recommendations
ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making.
Schmoll HJ, Van Cutsem E, Stein A, et al. Ann Oncol. 2012 Oct;23(10):2479-516.
Public Health Sciences
Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study
Rauch A, Wieczorek D, Graf E, et al. Lancet 2012 Sept 27
- Study finds large proportion of intellectual disability is not genetically inherited, Medical News Today, October
- Intellectual disability likely not inherited, Medscape Today, September 28 [by free subscription only]
CDC authors are indicated in bold
Multiwalled carbon nanotube-induced gene signatures in the mouse lung: potential predictive value for human lung cancer risk and prognosis
Guo NL, Wan YW, Denvir J, Porter DW, Pacurari M, Wolfarth MG, Castranova V, Qian Y. J Toxicol Environ Health A. 2012 Sep 15;75(18):1129-53.
Association between adult height, genetic susceptibility and risk of glioma
Kitahara CM, Wang SS, Melin BS, Wang Z, Braganza M, Inskip PD, Albanes D, Andersson U, Beane Freeman LE, Buring JE, Carreon T, Feychting M, Gapstur SM, Gaziano JM, Giles GG, Hallmans G, Hankinson SE, Henriksson R, Hsing AW, Johansen C, Linet MS, McKean-Cowdin R, Michaud DS, Peters U, Purdue MP, Rothman N, Ruder AM, Sesso HD, Severi G, Shu XO, Stevens VL, Visvanathan K, Waters MA, White E, Wolk A, Zeleniuch-Jacquotte A, Zheng W, Hoover R, Fraumeni JF, Chatterjee N, Yeager M, Chanock SJ, Hartge P, Rajaraman P. Int J Epidemiol. 2012 Aug;41(4):1075-1085.
Serotypes and genetic profiles of Bordetella pertussis strains isolated in the city of Sao Paulo, 2006-2008
Leite D, Cassiday PK, Tatti KM, Vaz TM, Tondella ML. J Pediatr (Rio J). 2012 Jul-Aug;88(4):357-60.
The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum
Neafsey DE, Galinsky K, Jiang RH, Young L, Sykes SM, Saif S, Gujja S, Goldberg JM, Young S, Zeng Q, Chapman SB, Dash AP, Anvikar AR, Sutton PL, Birren BW, Escalante AA, Barnwell JW, Carlton JM. Nat Genet. 2012 Sep;44(9):1046-50.
Tachibana S, Sullivan SA, Kawai S, Nakamura S, Kim HR, Goto N, Arisue N, Palacpac NM, Honma H, Yagi M, Tougan T, Katakai Y, Kaneko O, Mita T, Kita K, Yasutomi Y, Sutton PL, Shakhbatyan R, Horii T, Yasunaga T, Barnwell JW, Escalante AA, Carlton JM, Tanabe K. Nat Genet. 2012 Aug 5;44(9):1051-5.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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