Genomics & Health Impact Update

Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science.  To receive this update electronically every week sign-up here.

Thursday, May 31, 2012       Volume 28   Number 22

Spotlight

Evidence on Gene-Environment Interaction: How do we know it is there?

New Publication: Boffetta P, Winn DM, Ioannidis JP, et al. Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans. Int J Epidemiol. 2012 May 16.

• Blog on gene-environment interaction: Shall we have pie or stew?
• Khoury MJ, Gwinn M, Clyne M, Yu W. Genetic epidemiology with a capital E, ten years after. Genet Epidemiol 2011 Dec;35(8):845-52
• New Publication: Aschard H, Chen J, Cornelis MC, et al. Inclusion of Gene-Gene and Gene-Environment Interactions Unlikely to Dramatically Improve Risk Prediction for Complex Diseases Am J Hum Genet. 2012 May 23.

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Genomic Pulse

• Between 2001 and 2010, more than 57,000 articles were published on gene-disease associations.  Gene-environment interaction was mentioned explicitly only in 17% of published abstracts, almost half of which focused on gene-drug interactions. To find out more, click here

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Announcements

• New: CDC Public Health Genomics 2012 At a Glance: Realizing Opportunities for Genomics to Improve Health
• New Publications:
  • A population approach to precision medicine
    Khoury MJ, et al. Am J Prev Med 2012 Jun;42(6):639-45
  • Multilevel research and the challenges of implementing genomic medicine.
    Khoury MJ, Coates RJ, Fennell ML, et al. .J Natl Cancer Inst Monogr. 2012 ;2012(44):112-20.
• A May 2012 special issue of the Journal of the National Cancer Institute:
  Understanding and Influencing Multilevel Factors Across the Cancer Care Continuum,
• New Blog Post: Workings of an evidence-based genomic panel
• New CDC feature: Skin cancer awareness: Protect your skin
  • Learn more about genetics of skin cancer and relationship to environment
    from the National Cancer Institute
  • Learn about genes associated with skin cancer from the HuGE Navigator
• New CDC feature: Pregnant? Don’t smoke
  • Blog post: Smokescreen: Never let genetics blind you to the harsh reality of cigarettes
    

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Topics of the Week

Cancer

• A diagnostic genetic test for the physical mapping of germline rearrangements in the susceptibility breast cancer genes BRCA1 and BRCA2.
  Cheeseman K, Rouleau E, Vannier A, et al. Hum Mutat. 2012 Jun;33(6):998-1009.

  • Genetic susceptibility to breast cancer: a new, more accurate diagnostic test for mutation screening, World News Report, May 29
• Family perspectives in lynch syndrome becoming a family at risk, patterns of communication and influence on relations
  Bartuma K, et al. Hered Cancer Clin Pract 2012 May;10(1):6

Cardiovascular Disease

• Association between Family History and Coronary Heart Disease Death across Long-Term Follow-Up in Men: The Cooper Center Longitudinal Study
  Bachmann JM, et al. Circulation 2012 May

• Family history differs between young women with myocardial infarction and ischemic stroke: Results from the RATIO case-control study
  Siegerink B, et al. Atherosclerosis 2012 May

Genetic Testing in Practice

• Clinical utility gene card for: Centronuclear and myotubular myopathies
  Biancalana V, et al. Eur J Hum Genet 2012 May
• Gene test results to be passed on without consent, The Sydney Morning Herald, May 30

• Risk stratification by residual enzyme activity after newborn screening for medium-chain acyl-CoA dehyrogenase deficiency: Data from a cohort study
  Touw CM, et al. Orphanet J Rare Dis 2012 May;7(1):30

• The business value and cost–effectiveness of genomic medicine
  Crawford J, Aspinall M. Future Medicine 2012; 9(3):265-286

Policy and Legislation

• Biomarkers Unbound - The Supreme Court's Ruling on Diagnostic-Test Patents
  Kesselheim AS & Karlawish J N Engl J Med 2012 May

• Genetics and Cardiovascular Disease: A Policy Statement From the American Heart Association
  Ashley E, Hershberger, R, Caleshu, C, et al. Circulation, 2012 May 29

  • AHA recommends more safeguards for genetic testing, The Doctors Lounge, May 29

Guidelines and Recommendations

• Recommendations for ethical approaches to genotype-driven research recruitment
  Beskow LM, et al. Hum Genet 2012 May

• The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy
  Wilke RA, et al. Clin Pharmacol Ther 2012 May

Public Health Sciences

• The Centers for Mendelian Genomics: A new large-scale initiative to identify the genes underlying rare Mendelian conditions
  Bamshad MJ, et al. Am J Med Genet A 2012 May

• Predicting inhaled corticosteroid response in asthma with two associated SNPs
  McGeachie MJ, et al. Pharmacogenomics J 2012 May

• The Pediatric Cancer Genome Project
  Downing JR, Wilson RK, Zhang J, et al. Nat Genet. 2012 May 29;44(6):619-22.

  • World's largest release of comprehensive human cancer genome data helps speed discoveries, Medical Xpress, May 29

Funding in Translational Genomics

• NHGRI plans $14M grant for clinically relevant variants resource, Genome Web, May 28 [by free subscription only]

• NHGRI, NICHD plan $25M newborn sequencing screening grants program, Genome Web, May 25 [by free subscription only]
  

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CDC-Authored Genomics Publications

CDC authors are indicated in bold

View previous CDC-authored publications

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