Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science. To receive this update electronically every week sign-up here.
Thursday, May 31, 2012 Volume 28 Number 22
Evidence on Gene-Environment Interaction: How do we know it is there?
New Publication: Boffetta P, Winn DM, Ioannidis JP, et al. Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans. Int J Epidemiol. 2012 May 16.
- Blog on gene-environment interaction: Shall we have pie or stew?
- Khoury MJ, Gwinn M, Clyne M, Yu W. Genetic epidemiology with a capital E, ten years after. Genet Epidemiol 2011 Dec;35(8):845-52
- New Publication: Aschard H, Chen J, Cornelis MC, et al. Inclusion of Gene-Gene and Gene-Environment Interactions Unlikely to Dramatically Improve Risk Prediction for Complex Diseases Am J Hum Genet. 2012 May 23.
- Between 2001 and 2010, more than 57,000 articles were published on gene-disease associations. Gene-environment interaction was mentioned explicitly only in 17% of published abstracts, almost half of which focused on gene-drug interactions. To find out more, click here
- New: CDC Public Health Genomics 2012 At a Glance: Realizing Opportunities for Genomics to Improve Health
- New Publications:
- A population approach to precision medicine
Khoury MJ, et al. Am J Prev Med 2012 Jun;42(6):639-45
- Multilevel research and the challenges of implementing genomic medicine.
Khoury MJ, Coates RJ, Fennell ML, et al. .J Natl Cancer Inst Monogr. 2012 ;2012(44):112-20.
- A population approach to precision medicine
- A May 2012 special issue of the Journal of the National Cancer Institute:
Understanding and Influencing Multilevel Factors Across the Cancer Care Continuum,
- New Blog Post: Workings of an evidence-based genomic panel
- New CDC feature: Skin cancer awareness: Protect your skin
- New CDC feature: Pregnant? Don’t smoke
A diagnostic genetic test for the physical mapping of germline rearrangements in the susceptibility breast cancer genes BRCA1 and BRCA2.
Cheeseman K, Rouleau E, Vannier A, et al. Hum Mutat. 2012 Jun;33(6):998-1009.
- Genetic susceptibility to breast cancer: a new, more accurate diagnostic test for mutation screening, World News Report, May 29
- Family perspectives in lynch syndrome becoming a family at risk, patterns of communication and influence on relations
Bartuma K, et al. Hered Cancer Clin Pract 2012 May;10(1):6
Association between Family History and Coronary Heart Disease Death across Long-Term Follow-Up in Men: The Cooper Center Longitudinal Study
Bachmann JM, et al. Circulation 2012 May
Family history differs between young women with myocardial infarction and ischemic stroke: Results from the RATIO case-control study
Siegerink B, et al. Atherosclerosis 2012 May
Genetic Testing in Practice
- Clinical utility gene card for: Centronuclear and myotubular myopathies
Biancalana V, et al. Eur J Hum Genet 2012 May
- Gene test results to be passed on without consent, The Sydney Morning Herald, May 30
Risk stratification by residual enzyme activity after newborn screening for medium-chain acyl-CoA dehyrogenase deficiency: Data from a cohort study
Touw CM, et al. Orphanet J Rare Dis 2012 May;7(1):30
The business value and cost–effectiveness of genomic medicine
Crawford J, Aspinall M. Future Medicine 2012; 9(3):265-286
Policy and Legislation
Biomarkers Unbound - The Supreme Court's Ruling on Diagnostic-Test Patents
Kesselheim AS & Karlawish J N Engl J Med 2012 May
Genetics and Cardiovascular Disease: A Policy Statement From the American Heart Association
Ashley E, Hershberger, R, Caleshu, C, et al. Circulation, 2012 May 29
- AHA recommends more safeguards for genetic testing, The Doctors Lounge, May 29
Guidelines and Recommendations
Recommendations for ethical approaches to genotype-driven research recruitment
Beskow LM, et al. Hum Genet 2012 May
The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy
Wilke RA, et al. Clin Pharmacol Ther 2012 May
Public Health Sciences
The Centers for Mendelian Genomics: A new large-scale initiative to identify the genes underlying rare Mendelian conditions
Bamshad MJ, et al. Am J Med Genet A 2012 May
Predicting inhaled corticosteroid response in asthma with two associated SNPs
McGeachie MJ, et al. Pharmacogenomics J 2012 May
The Pediatric Cancer Genome Project
Downing JR, Wilson RK, Zhang J, et al. Nat Genet. 2012 May 29;44(6):619-22.
- World's largest release of comprehensive human cancer genome data helps speed discoveries, Medical Xpress, May 29
Funding in Translational Genomics
NHGRI plans $14M grant for clinically relevant variants resource, Genome Web, May 28 [by free subscription only]
NHGRI, NICHD plan $25M newborn sequencing screening grants program, Genome Web, May 25 [by free subscription only]
CDC authors are indicated in bold
Molecular characterization of diarrheagenic Escherichia coli from Libya
Ali MM, Mohamed ZK, Klena JD, Ahmed SF, Moussa TA, Ghenghesh KS. Am J Trop Med Hyg. 2012 May;86(5):866-71.
Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans
Boffetta P, Winn DM, Ioannidis JP, Thomas DC, Little J, Davey Smith G, Cogliano VJ, Hecht SS, Seminara D, Vineis P, Khoury MJ. Int J Epidemiol. 2012 May 16.
The Jamaican historical experience of the impact of educational interventions on sickle cell disease child mortality
Grosse SD, Atrash HK, Odame I, Amendah D, Piel FB, Williams TN. Am J Prev Med. 2012 Jun;42(6):e101-3.
Detectable clonal mosaicism and its relationship to aging and cancer
Jacobs KB, Yeager M, Zhou W, Wacholder S, Wang Z, Rodriguez-Santiago B, Hutchinson A, Deng X, Liu C, Horner MJ, Cullen M, Epstein CG, Burdett L, Dean MC, Chatterjee N, Sampson J, Chung CC, Kovaks J, Gapstur SM, Stevens VL, Teras LT, Gaudet MM, Albanes D, Weinstein SJ, Virtamo J, Taylor PR, Freedman ND, Abnet CC, Goldstein AM, Hu N, Yu K, Yuan JM, Liao L, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Aldrich MC, Amos C, Blot WJ, Bock CH, Gillanders EM, Harris CC, Haiman CA, Henderson BE, Kolonel LN, Le Marchand L, McNeill LH, Rybicki BA, Schwartz AG, Signorello LB, Spitz MR, Wiencke JK, Wrensch M, Wu X, Zanetti KA, Ziegler RG, Figueroa JD, Garcia-Closas M, Malats N, Marenne G, Prokunina-Olsson L, Baris D, Schwenn M, Johnson A, Landi MT, Goldin L, Consonni D, Bertazzi PA, Rotunno M, Rajaraman P, Andersson U, Freeman LE, Berg CD, Buring JE, Butler MA, Carreon T, Feychting M, Ahlbom A, Gaziano JM, Giles GG, Hallmans G, Hankinson SE, Hartge P, Henriksson R, Inskip PD, Johansen C, Landgren A, McKean-Cowdin R, Michaud DS, Melin BS, Peters U, Ruder AM, et al. Nat Genet. 2012 May 6.
Multilevel research and the challenges of implementing genomic medicine
Khoury MJ, Coates RJ, Fennell ML, Glasgow RE, Scheuner MT, Schully SD, Williams MS, Clauser SB. J Natl Cancer Inst Monogr. 2012 ;2012(44):112-20.
A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia
Milton JN, Sebastiani P, Solovieff N, Hartley SW, Bhatnagar P, Arking DE, Dworkis DA, Casella JF, Barron-Casella E, Bean CJ, Hooper WC, Debaun MR, Garrett ME, Soldano K, Telen MJ, Ashley-Koch A, Gladwin MT, Baldwin CT, Steinberg MH, Klings ES. PLoS One. 2012 ;7(4):e34741.
HIV type 1 gag genetic diversity among antenatal clinic attendees in North Rift Valley, Kenya
Nyagaka B, Kiptoo MK, Lihana RW, Khamadi SA, Makokha EP, Kinyua JG, Mwangi J, Osman S, Lagat NJ, Muriuki J, Okoth V, Gicheru M, Ng'ang'a Z, Songok EM. AIDS Res Hum Retroviruses. 2012 May;28(5):523-6.
The prevalence of HLA-B27 in the US: data from the US National Health and Nutrition Examination Survey, 2009
Reveille JD, Hirsch R, Dillon CF, Carroll MD, Weisman MH. Arthritis Rheum. 2012 May;64(5):1407-11.
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels
Scott RA, Chu AY, Grarup N, Manning AK, Hivert MF, Shungin D, Tonjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer NL, Jackson AU, Kutalik Z, Lagou V, Marek D, Rasmussen-Torvik LJ, Stringham HM, Tanaka T, Aadahl M, Arking DE, Bergmann S, Boerwinkle E, Bonnycastle LL, Bornstein SR, Brunner E, Bumpstead SJ, Brage S, Carlson OD, Chen H, Chen YD, Chines PS, Collins FS, Couper DJ, Dennison EM, Dowling NF, et al. Diabetes. 2012 May;61(5):1291-6.
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