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Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science. To receive this update electronically every week sign-up here.
Thursday, May 24, 2012 Volume 28 Number 21
Highlights of the week
Spotlight
Evidence on Gene-Environment Interaction: How do we know it is there?
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New Publication: Boffetta P, Winn DM, Ioannidis JP, et al. Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans. Int J Epidemiol. 2012 May 16.
- Blog on gene-environment interaction: Shall we have pie or stew?
- Khoury MJ, Gwinn M, Clyne M, Yu W. Genetic epidemiology with a capital E, ten years after. Genet Epidemiol 2011 Dec;35(8):845-52
- Khoury MJ, Wacholder S. Invited commentary: from genome-wide association studies to gene-environment-wide interaction studies--challenges and opportunities. Am J Epidemiol. 2009 Jan 15;169(2):227-30.
- Gwinn M, Guessous I, Khoury MJ. Invited commentary: genes, environment, and hybrid vigor. Am J Epidemiol. 2009 Sep 15;170(6):703-7.
Genomic Pulse
- Between 2001 and 2010, more than 57,000 articles were published on gene-disease associations. Gene-environment interaction was mentioned explicitly only in 17% of published abstracts, almost half of which focused on gene-drug interactions. To find out more, click here
Announcements
- New Publication: A population approach to precision medicine
Khoury MJ, et al. Am J Prev Med 2012 Jun;42(6):639-45 - New Blog Post: Workings of an Evidence-Based Genomic Panel
- High Blood Pressure
- May is high blood pressure education month: have your blood pressure checked and monitored regularly
- Know your family history of high blood pressure [PDF 94.84 KB], it may be important to you
- Know your family health history, it could save your life
- What do Genes have to do with Obesity?
- Blog Post: Sharing the Burden of Obesity
- New: Behavior, environment, and genetic factors all have a role in causing people to be overweight and obese, Office of Public Health Genomics
- New: Genes and obesity, Office of Public Health Genomics
- Blog Post: Genomic Tests and Population Health: An Online Catalog to Promote a Conversation on Evolving Evidence
Topics of the Week
Breast Cancer
- Intragenic ATM Methylation in Peripheral Blood DNA as a Biomarker of Breast Cancer Risk
Brenan K, et al. Cancer Re.2012 May 1;72(9):2304-2313- Can a simple blood test really predict breast cancer?
McCartney M BMJ 2012;344:e3374
- Can a simple blood test really predict breast cancer?
- Long-term results of screening with magnetic resonance imaging in women with BRCA mutations
Passaperuma K, et al. Br J Cancer 2012 May
Colorectal Cancer
- Does a screening questionnaire for familial and hereditary colorectal cancer risk work in a health insurance population?
Pieper C, et al. Eur J Cancer Care (Engl) 2012 May
Cardiovascular Disease
- Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Voight B, Orgo-Melander M, et al. Lancet 2012 May 17- Mendelian randomisation, lipids, and cardiovascular disease
Harrison S, Holmes M, Humphries S Lancet 2012 (not available without a subscription) - Genetic study questions HDL levels and the risk of MI, Medscape, May 17 [by free subscription only]
- Mendelian randomisation, lipids, and cardiovascular disease
Genetic Testing in Practice
- A Study of Thrombophilia Testing and Counseling Practices of Family Physicians Using the Script Concordance Method in Calgary, Canada
Schneider-Macrae N, et al. Clin Appl Thromb Hemost 2012 May - Association between health-service use and multiplex genetic testing
Reid RJ, et al. Genet Med 2012 May - Operational Implementation of Prospective Genotyping for Personalized Medicine: The Design of the Vanderbilt PREDICT Project
Pulley JM, et al. Clin Pharmacol Ther 2012 May - Personalized Genomic Testing for Disease Risk
Committee Opinion No. 527 American College of Obstetricians and Gynecologists June 2012- Personalized genetic testing not recommended, CNN Health, May 22
- Diagnostic approaches to apparent homozygosity
Landsverk ML, et al. Genet Med 2012 May - Nurses' competence in genetics: a mixed method systematic review
Skirton H, et al. J Adv Nurs 2012 May - One Community's Effort to Control Genetic Disease
Strauss KA, et al. Am J Public Health 2012 May - Genetic basis for personalized medicine in asthma, Medscape, May 21
- Genomics and world health: a decade on Pang T & Weatherall D Lancet 2012 May;379(9829):1853-4
Policy and Legislation
- Disclosure and management of research findings in stem cell research and banking: policy statement
Isasi R, et al. Regen Med 2012 May;7(3):439-48 - California considers DNA privacy law, Nature News, May 18
- The fate and future of patents on human genes and genetic diagnostic methods.
Huys I, Matthijs G, Van Overwalle G. Nat Rev Genet. 2012 May 18;13(6):441-8. - Public Comments and Notice of Public Hearings on Genetic Diagnostic Testing, USPTO
- USPTO Posts Comments on Genetic Diagnostic Testing, Patent Docs
- Electronic family health history records draw attention: Proposed federal regulation and new tool emphasize digital conversion Am J Med Genet A 2012 Jun;158A(6):ix-x
Public Health Sciences
- Genome-wide meta-analyses of smoking behaviors in African Americans
David S, Hamidovic A, Chen G, et al. Translational Psychiatry (2012) 2, e119- Genetic marker may predict smoking quantity in African Americans, EurekAlert, May 22
- An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People.
Nelson MR, Wegmann D, Ehm MG, et al. Science. 2012 May 17.- Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes.
Tennessen JA, Bigham AW, O'Connor TD, et al. Science. 2012 May 17. - Many rare mutations may underpin diseases, The New York Times, May 17
- Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes.
CDC-Authored Genomics Publications
CDC authors are indicated in bold
Convergence and coevolution of Hepatitis B virus drug resistance
Thai H, Campo DS, Lara J, Dimitrova Z, Ramachandran S, Xia G, Ganova-Raeva L, Teo CG, Lok A, Khudyakov Y.
Nat Commun. 2012 ;3:789.
Evidence of purifying selection on merozoite surface protein 8 (MSP8) and 10 (MSP10) in Plasmodium spp
Pacheco MA, Elango AP, Rahman AA, Fisher D, Collins WE, Barnwell JW, Escalante AA.
Infect Genet Evol. 2012 Jul;12(5):978-86.
View previous CDC-authored publications
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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