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Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science. To receive this update electronically every week sign-up here.
Thursday, May 17, 2012 Volume 28 Number 20
Highlights of the week
Spotlight
What do genes have to do with obesity?
New Blog Post: Sharing the Burden of Obesity
New: Behavior, environment, and genetic factors all have a role in causing people to be overweight and obese, Office of Public Health Genomics
New: Genes and obesity, Office of Public Health Genomics
- Weight of the Nation, CDC Feature
- CDC 2012 Weight of the Nation Conference
- CDC strategies to combat obesity for me, for my family and for my community
- Weight of the Nation: Documentary Films and Institute of Medicine (IOM) four-part series confronting America's obesity epidemic
- Public health genomics: translating obesity genomics research into population health benefits.
Agurs-Collins T, Khoury MJ, et al. Obesity. 2008 Dec;16 Suppl 3:S85-94
Genomic Pulse
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Since 2001, 2777 scientific articles by more than 12400 investigators have addressed the relationship of 1434 different genes with obesity. To find out more, click here
Announcements
- Blog Post: Genomic Tests and Population Health: An Online Catalog to Promote a Conversation on Evolving Evidence
- Two publications in PLoS Currents Evidence on Genomic Tests
- Genetic testing for long QT syndrome and the category of cardiac ion channelopathies
Modell S, Bradley D. PLoS Currents Evidence on Genomic Tests May 3
- Comprehensive Carrier Screening and Molecular Diagnostic Testing for Recessive Childhood Diseases
Kingsmore S. PLoS Currents Evidence on Genomic Tests May 2
- Genetic testing for long QT syndrome and the category of cardiac ion channelopathies
Topics of the Week
Breast Cancer
- A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy
Hallett R, Pond G, Hassell J. BMC Medical Genomics 2012; 5:16 - The landscape of cancer genes and mutational processes in breast cancer
Stephens P, Tarpey P, Davies H, et al. Nature 2012 May 16- Breast cancer study reveals 'substantial genetic diversity', The Los Angeles Times, May 16
- DNA-testing for BRCA1/2 prior to genetic counseling in patients with breast cancer: Design of an intervention study, DNA-direct
Sie AS, et al. BMC Womens Health 2012 May;12(1):12 - Adoption of Gene Expression Profile Testing and Association With Use of Chemotherapy Among Women With Breast Cancer
Hassett MJ, et al. J Clin Oncol 2012 May - Assessing individual breast cancer risk within the UK National Health Service Breast Screening Programme: a new paradigm for cancer prevention
Evans DG, et al. Cancer Prev Res (Phila) 2012 May
Colorectal Cancer
- Risk for colorectal cancer in persons with a family history of adenomatous polyps: a systematic review
Imperiale TF & Ransohoff DF Ann Intern Med 2012 May;156(10):703-9 - Influence of Family History of Colorectal Cancer on Health Behavior and Performance of Early Detection Procedures: The SUN Project
Martinez-Ochoa E, et al. Ann Epidemiol 2012 May
Prostate Cancer
- Global Methylation Profiling for Risk Prediction of Prostate Cancer
Mahapatra S, Klee E, Young C, et al. Clinical Cancer Research 2012 May 15 - Prostate cancer risk assessment model: a scoring model based on the Swedish Family-Cancer Database
Roudgari H, et al. J Med Genet 2012 May;49(5):345-52
Renal Cancer
- The Clinical Utility of miR-21 as a Diagnostic and Prognostic Marker for Renal Cell Carcinoma
Faragalla H, et al. J Mol Diagn 2012 May
Alzheimer's Disease
- New drug trial seeks to stop Alzheimer’s before it starts, The New York Times, May 15
Heart Disease
- Is the process of delivery of an individually tailored lifestyle intervention associated with improvements in LDL cholesterol and multiple lifestyle behaviours in people with Familial Hypercholesterolemia?
Broekhuizen K, et al. BMC Public Health 2012 May;12(1):348
Eye Diseases
- Collaborative Ocular Oncology Group Report Number 1: Prospective Validation of a Multi-Gene Prognostic Assay in Uveal Melanoma.
Onken MD, Worley LA, Char DH, et al. Ophthalmology. 2012 Apr 20.- Genetic test identifies eye cancer tumors likely to spread, Science Daily, May 14
- A paradigm shift in the delivery of services for diagnosis of inherited retinal disease
O'Sullivan J, et al. J Med Genet 2012 May;49(5):322-6
ELSI
- ELSI 2.0 for Genomics and Society
Kaye J, et al. Science 2012 May;336(6082):673-4
Family History
- Assessing Disease Risk in Genome-wide Association Studies Using Family History
Ghosh A, et al. Epidemiology 2012 May
Genetic Testing
- Attitudes and Practices Among Internists Concerning Genetic Testing
Klitzman R, et al. J Genet Couns 2012 May - Charcot-Marie-Tooth disease: frequency of genetic subtypes and guidelines for genetic testing
Murphy SM, et al. J Neurol Neurosurg Psychiatry 2012 May
CDC-Authored Genomics Publications
CDC authors are indicated in bold
Evaluation of mycobacterial interspersed repetitive-unit-variable-number tandem-repeat genotyping as performed in laboratories in Canada, France, and the United States
Cowan LS, Hooks DP, Christianson S, Sharma MK, Alexander DC, Guthrie JL, Jamieson FB, Supply P, Allix-Beguec C, Cruz L, Desmond E, Kramer R, Lugo S, Rudrik J. J Clin Microbiol. 2012 May;50(5):1830-1.
Infection and transmission of Rift Valley fever viruses lacking the NSs and/or NSm genes in mosquitoes: potential role for NSm in mosquito infection
Crabtree MB, Kent Crockett RJ, Bird BH, Nichol ST, Erickson BR, Biggerstaff BJ, Horiuchi K, Miller BR. PLoS Negl Trop Dis. 2012 May;6(5):e1639.
Knowledge integration at the center of genomic medicine
Khoury MJ, Gwinn M, Dotson WD, Schully SD. Genet Med. 2012 May 3.
Surveillance of transmitted HIV drug resistance using matched plasma and dried blood spot specimens from voluntary counseling and testing sites in Ho Chi Minh City, Vietnam, 2007-2008
Duc NB, Hien BT, Wagar N, Tram TH, Giang le T, Yang C, Wolfe MI, Hien NT, Tuan NA. Clin Infect Dis. 2012 May;54 Suppl 4:S343-7.
View previous CDC-authored publications
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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