 For information on genomic applications in cancer care and prevention, please visit the CancerGEM Knowledge Base |
Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science. To receive this update electronically every week sign-up here.
Thursday, May 10, 2012 Volume 28 Number 19
Highlights of the week
Spotlight
What do genes have to do with obesity?
NEW: Behavior, environment, and genetic factors all have a role in causing people to be overweight and obese, Office of Public Health Genomics
NEW: Genes and obesity, Office of Public Health Genomics
- CDC 2012 Weight of the Nation Conference
- CDC strategies to combat obesity for me, for my family and for my community
- Weight of the Nation: Documentary Films and Institute of Medicine (IOM) four-part series confronting America's obesity epidemic
- Public health genomics: translating obesity genomics research into population health benefits.
Agurs-Collins T, Khoury MJ, et al. Obesity. 2008 Dec;16 Suppl 3:S85-94
Genomic Pulse
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Since 2001, 2777 scientific articles by more than 12400 investigators have addressed the relationship of 1434 different genes with obesity. To find out more, click here
Announcements
- Blog Post: Genomic Tests and Population Health: An Online Catalog to Promote a Conversation on Evolving Evidence
- Amyotrophic Lateral Sclerosis (ALS) Awareness Month — May 2012
- International Thalassemia Day was May 8th. To find out more about thalassemia, please visit the CDC Feature.
- Two publications in PLoS Currents Evidence on Genomic Tests
- Genetic testing for long QT syndrome and the category of cardiac ion channelopathies
Modell S, Bradley D. PLoS Currents Evidence on Genomic Tests May 3
- Comprehensive Carrier Screening and Molecular Diagnostic Testing for Recessive Childhood Diseases
Kingsmore S. PLoS Currents Evidence on Genomic Tests May 2
- Genetic testing for long QT syndrome and the category of cardiac ion channelopathies
- Focus on Comparative Effectiveness Research for Evaluating and Implementing Genomics in Practice
- Knowledge integration at the center of genomic medicine.
Khoury MJ, Gwinn M, Dotson WD, Schully SD. Genet Med. 2012 May 3. - Building the evidence base for decision making in cancer genomic medicine using comparative effectiveness research
Goddard KA, et al. Genet Med 2012 Apr - Stakeholder assessment of the evidence for cancer genomic tests: insights from three case studies.
Deverka PA, Schully SD, et al. Genet Med. 2012 Apr 5. - Comparative effectiveness research and genomic medicine: An evolving partnership for 21st century medicine.
Khoury MJ, Rich EC, Randhawa G, et al.Genet Med. 2009 Sep 11.
- Knowledge integration at the center of genomic medicine.
Topics of the Week
- What's New in Newborn Screening?
- Ethical Issues with Newborn Screening in the Genomics Era
Tarini BA & Goldenberg AJ Annu Rev Genomics Hum Genet 2012 May - Newborn screening programmes in Europe; arguments and efforts regarding harmonization. Part 1 - From blood spot to screening result
Loeber JG, et al. J Inherit Metab Dis 2012 May - Newborn Screening Services in Bahrain between 1985 and 2010
Al Arrayed S & Al Hajeri A Adv Hematol 2012;2012:903219 - House approves revamp of newborn screening consent, Marshall Independent, May 4
- Newborns will now be screened for SCID, LXAN, May 3
- Newborn Screening Webinar Series: Ownership and Control of Specimens
May 31 ~ Webinar
- Ethical Issues with Newborn Screening in the Genomics Era
- Importance of Family History in the Genomics Age
- Family history: Still relevant in the genomics era
Doerr M & Teng K Cleve Clin J Med 2012 May;79(5):331-6 - Personalised care and the genome
Doerr M & Eng C BMJ 2012;344:e3174 - Blog Post: Emerging Evidence for the Benefits of Systematic Collection of Family History in Primary Care
- Family history: Still relevant in the genomics era
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Genetic Testing to Guide Interventions
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Sudden Cardiac Death of the Young
- The Costs and Benefits of Targeted Screening for Causes of Sudden Cardiac Death in Children and Adolescents.
Leslie LK, Cohen JT, Newburger JW, et al. Circulation. 2012 May 3. - Costs of screening children for sudden cardiac death outweigh its benefits, EurekAlert, May 9
- Screening clinic shows "huge promise" for hidden heart problems, BBC News, May 7
- Blog Post: Can Sudden Cardiac Death of the Young be Prevented?
- The Costs and Benefits of Targeted Screening for Causes of Sudden Cardiac Death in Children and Adolescents.
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Cystic Fibrosis
- Promising new era dawns for cystic fibrosis treatment, The Lancet, April 21
- A cystic fibrosis treatment is called ‘game-changing’, The New York Times, May 7
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Prostate Cancer
- Genome Abnormalities Precede Prostate Cancer and Predict Clinical Relapse
Yu Y, Song C, Tseng G, et al. 2012 Journal of Pathology May 9 - Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer, EurekAlert, May 7
- Genome Abnormalities Precede Prostate Cancer and Predict Clinical Relapse
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Cardiovascular Disease
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- Gene Pollution and Drug Resistance
- Fears of gene pollution emerge in TJ river, UT San Diego, May 6
- New issue in the Italian Journal of Public Health dedicated to Public Health Genomics
CDC-Authored Genomics Publications
CDC authors are indicated in bold
Evaluation for West Nile Virus (WNV) RNA in urine of patients within 5 months of WNV infection
Baty SA, Gibney KB, Staples JE, Patterson AB, Levy C, Lehman J, Wadleigh T, Feld J, Lanciotti R, Nugent CT, Fischer M.
J Infect Dis. 2012 May;205(9):1476-7.
The impact of genomics on public health practice: the case for change
Zimmern RL, Khoury MJ. Public Health Genomics. 2012 ;15(3-4):118-24.
Implications of Internet availability of genomic information for public health practice
Hesse BW, Arora NK, Khoury MJ. Public Health Genomics. 2012 ;15(3-4):201-8.
Introduction to the 4th National Conference on Genomics and Public Health
McBride CM, Bowen SM, Shully SD, Khoury MJ. Public Health Genomics. 2012 ;15(3-4):117.
Rapid detection of microbial DNA by a novel isothermal genome exponential amplification reaction (GEAR) assay
Prithiviraj J, Hill V, Jothikumar N. Biochem Biophys Res Commun. 2012 Apr 20;420(4):738-42.
View previous CDC-authored publications
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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