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Genomics & Health Impact Update

Published by the Office of Public Health Genomics (OPHG), the Update offers links to genomics news and publications relevant to population health and health care. The Update highlights family health history and genomic tests, along with relevant data, policy, and legislation. Please send your comments to:

Thursday, March 8, 2012       Volume 28   Number 10

Highlights of the Week:


person running with EKG graph

New Blog Post: Can Sudden Cardiac Death of the Young be Prevented?


Selected Items

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Genomic Tests

For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base and PLoS Currents Evidence on Genomic Tests.

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Family Health History

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Practice and Programs

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Public Health Science

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
Gerlinger M, Rowan A, Horswell S, et al. N Engl J Med 2012;366:883-892

Tumor Heterogeneity and Personalized Medicine
Dan L. Longo, M.D. N Engl J Med 2012; 366:956-957 2012 Mar

Genetic Influences on Developmental Smoking Trajectories
Lessov-Schlaggar CN, et al. Addiction 2012 Mar

The development and validation of a clinical prediction model to determine the probability of MODY in patients with young-onset diabetes
Shields BM, et al. Diabetologia 2012 Mar

To test, or not to test: time for a MODY calculator?
Njolstad PR & Molven A Diabetologia 2012 Mar

A more rapid approach to systematically assessing published associations of genetic polymorphisms and disease risk: type 2 diabetes as a test case
Cho AH, Jiang X, Mann DM, Kawamoto K, Robinson TJ, Wang N, McCarthy JJ, Woodward M, Ginsburg GS, Comparative Effectiveness Research, January 2012;2:1 – 20

Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle
Barrès R, Yan J, Egan B, et al. Cell Metabolism 2012, 15(3);405-411

Exercise changes your DNA, Medical Press, March 6

73 human genome epidemiology articles have recently been added, please visit the HuGE Literature Finder in the HuGE Navigator.

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CDC-Authored Genomics Publications

CDC authors are indicated in bold

A distinct lineage of influenza A virus from bats
Tong S, Li Y, Rivailler P, Conrardy C, Castillo DA, Chen LM, Recuenco S, Ellison JA, Davis CT, York IA, Turmelle AS, Moran D, Rogers S, Shi M, Tao Y, Weil MR, Tang K, Rowe LA, Sammons S, Xu X, Frace M, Lindblade KA, Cox NJ, Anderson LJ, Rupprecht CE, Donis RO.
Proc Natl Acad Sci U S A. 2012 Feb 27.
Matern Child Health J. 2012 Feb;16(2):486-94.

A real-time PCR assay for HPV52 detection and viral load quantification
Onyekwuluje JM, Steinau M, Swan DC, Unger ER.
Clin Lab. 2012 ;58(1-2):61-6.

Atypical Listeria monocytogenes serotype 4b strains harboring a lineage II-specific gene cassette
Lee S, Ward TJ, Graves LM, Wolf LA, Sperry K, Siletzky RM, Kathariou S.
Appl Environ Microbiol. 2012 Feb;78(3):660-7.

Development of a novel genus-specific real-time PCR assay for detection and differentiation of Bartonella species and genotypes
Diaz MH, Bai Y, Malania L, Winchell JM, Kosoy MY.
J Clin Microbiol. 2012 Feb 29.

Novel genetic variation identified at fixed loci in ORF62 of the Oka varicella vaccine and in a case of vaccine-associated herpes zoster
Quinlivan ML, Jensen NJ, Radford KW, Schmid DS.
J Clin Microbiol. 2012 Feb 29.

View previous CDC-authored publications

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Let's Go Surfing

Market watch: Industry perspectives on personalized medicine
Zuckerman R & Milne CP Nat Rev Drug Discov 2012;11(3):178

Putting genome analysis to good use: Lessons from C-reactive protein and cardiovascular disease
Manace LC & Babyatsky MW Cleve Clin J Med 2012 Mar;79(3):182-91.

What do our patients think personalized medicine means? The answer may surprise you
Wujcik DM ONS Connect 2012 Feb;27(2):7

The great beyond
Nature. 2012 Feb 29;483(7387):5-6.

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Events and Training

The Conference of the Global Sickle Cell Disease Network
March 15 ~ Atlanta, GA

Genomics Research 2012
April 19-20 ~ Boston, MA

NMBIST 2012- New Mexico BioInformatics, Science and Technology Symposium: Functional Genomics
March 22-23 ~ Santa Fe, NM

Access other events

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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.


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