Genomics & Health Impact Update

Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science.  To receive this update electronically every week sign-up here.

Thursday, June 21, 2012       Volume 28   Number 25

Spotlight

New Blog Post: Peeling the pyramid, scaling the onion—how to implement genomic medicine

• A framework for public health action: the health impact pyramid
  Frieden TR. AM J Public Health 2010;100:590-595.
• Multilevel research and the challenges of implementing genomic medicine.
  Khoury MJ, Coates RJ, Fennell ML, et al. J Natl Cancer Inst Monogr. 2012 ;2012(44):112-20.
• May 2012 special issue of the Journal of the National Cancer Institute:
  Understanding and Influencing Multilevel Factors Across the Cancer Care Continuum

 

---

Genomic Pulse

• Over a million people in the U.S. are predisposed to serious health problems and premature death due to Lynch syndrome, familial hypercholesterolemia, or BRCA-associated hereditary breast and ovarian cancer.  Evidence-based recommendations are available that can be adopted now to save lives. To find out more about tier 1 genomic applications, please click here

---

Tweets of the Week:

• Follow Dr. Khoury on Twitter

  • Translational #genomics has several phases of research in order to achieve health impact
  • Speaking this week at UK Conference on public health approach to translational genomics
  • World #SickleCell Awareness Day is June 19. Find out more at http://www.cdc.gov/Features/SickleGenoAtkins/
  • Happy #FathersDay! Know your family health history, it could save your life, find out more http://www.cdc.gov/genomics/famhistory/index.htm

---

Announcements

• The Human Microbiome Project
  • NIH Human Microbiome Project defines normal bacterial makeup of the body, NIH News, June 13
  • Tending the body’s microbial garden, The New York Times, June 18
  • A new genetic map that could make your skin crawl, PBS Newshour, June 14
  • Structure, function and diversity of the healthy human microbiome
    The Human Microbiome Project Consortium 2012 Jun 13 Nature 486, 207-214
• CDC feature: Cancer and Men
  • Know your family health history: it can save your life
  • Genetics and prostate cancer (from the National Cancer Institute)
• CDC feature: Tuberculosis
  • Learn the signs and symptoms of tuberculosis
  • Find out genetic susceptibility factors associated with tuberculosis. Consult the HuGE Navigator
• CDC feature: Sickle Cell Awareness
  • World Sickle Cell Awareness Day was June 19th
  • How Sickle Cell Trait is Inherited?
  • Stay Healthy with Sickle Cell Disease
• June 21 is P4 Medicine Awareness Day
  • A population approach to precision medicine.
    Khoury MJ, Gwinn ML, Glasgow RE, Kramer BS. Am J Prev Med. 2012 Jun;42(6):639-45.

---

Topics of the Week

Cancer

• Genomics: The breast cancer landscape
  Gray J, Druker B. Nature 2012; 486, 328-329

• Prostate Cancer Screening Among Ethnically Diverse First-Degree Relatives of Prostate Cancer Cases
  Glenn BA, et al. Health Psychol 2012 Jun

• The Role of Genetic Markers in the Management of Prostate Cancer
  Choudhury AD, et al. Eur Urol 2012 Jun

• Researchers find many centers don't refer women with family breast cancer history to genetic counseling, Genome Web, June 13 [by free subscription only]

Family History

• Family History of Myocardial Infarction Is a Risk Factor for Venous Thromboembolism Among Whites But Not Among Blacks
  Mili FD, et al. Clin Appl Thromb Hemost 2012 Jun

Cardiovascular Disease

• Genetic Associations for Activated Partial Thromboplastin Time and Prothrombin Time, their Gene Expression Profiles, and Risk of Coronary Artery Disease
  Tang W, Schwienbacher C, Lopez L, et al. American Journal of Human Genetics 2012 Jun 14

Genetic Testing in Practice

• HTA of genetic testing for susceptibility to venous thromboembolism in Italiy
  Betti S, Boccia A, Boccia S, et al. Italian Journal of Public Health 2012; 9(2) Suppl. 1

• Genetic services and testing in South Africa
  Kromberg JG, et al. J Community Genet 2012 Jun

• FDA official discusses issues with regulating NGS Dx tests, Genome Web, June 19 [by free subscription only]

• State reimbursements for genetic tests vary, OIG report finds, Genome Web, June 15 [by free subscription only]

Public Health Sciences

• Effect of communicating genetic and phenotypic risk for type 2 diabetes in combination with lifestyle advice on objectively measured physical activity: protocol of a randomised controlled trial
  Godino JG, et al. BMC Public Health 2012 Jun;12(1):444

• Non-Invasive Chromosomal Evaluation (NICE) Study: Results of a Multicenter, Prospective, Cohort Study for Detection of Fetal Trisomy 21 and Trisomy 18
  Norton M, Brar H, Weiss J, et al. American Journal of Obstetrics & Gynecology 2012 Jun 4

• Gender Modulates the APOE {varepsilon}4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels.
  Damoiseaux JS, Seeley WW, Zhou J, et al. J Neurosci. 2012 Jun 13;32(24):8254-8262.

  • Women have higher genetic risk of Alzheimer's, Medpage Today, June 15

Funding

• Human Heredity and Health in Africa (H3Africa): Ethical, Legal, and Societal Issues (ELSI) Research Program (U01)

Top of Page

---

CDC-Authored Genomics Publications

CDC authors are indicated in bold

View previous CDC-authored publications

Top of Page