Genomics & Health Impact Update

Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science.  To receive this update electronically every week sign-up here.

Thursday, June 14, 2012       Volume 28   Number 24

Spotlight

The Human Microbiome Project

Microbiology: Learning about who we are
Relman D 2012 Jun 13 Nature 486, 194-195

• NIH Human Microbiome Project defines normal bacterial makeup of the body, NIH News, June 13
• In Good Health? Thank Your 100 Trillion Bacteria, The New York Times, June 13
• Structure, function and diversity of the healthy human microbiome
  The Human Microbiome Project Consortium 2012 Jun 13 Nature 486, 207-214
• A framework for human microbiome research
  The Human Microbiome Project Consortium 2012 Jun 13 Nature 486, 215-221
• A Metagenomic Approach to Characterization of the Vaginal Microbiome Signature in Pregnancy
  Aagaard K, Riehle K, Ma J, et al. 2012 Jun 13 PLoS ONE 7(6): e36466

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Genomic Pulse

• While the human genome carries about 22,000 genes, researchers estimate that the human microbiome contributes 8 million or 360 times more bacterial genes than human genes in our bodies”.  To find out more

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Announcements

• CDC feature: E. coli infection
  • Although most strains of E. coli are harmless, others can make you sick. Learn more
  • Find out how genetic susceptibility is related to hemolytic-uremic syndrome, a rare but serious complication of E. coli infection. Search the HuGE Navigator
  • CDC Blog: Genome vs. Genome
• CDC feature: Men’s health
  • Males can take daily steps to live safer and healthier lives
  • Know your family health history: it can save your life
  • Heart disease and family history
  • Genetics and prostate cancer (from the National Cancer Institute)
  • Delayed paternal age of reproduction in humans is associated with longer telomeres across two generations of descendants
    Eisenberg D, Hayes M, Kuzawa C. PNAS Jun 11
    • Older dads may pass along a longer lifespan to their child, CBS News, June 11
• CDC feature: Sickle cell awareness
  • World Sickle Cell Awareness Day is June 19th
  • How is sickle cell trait inherited?

• Follow Dr Khoury on Twitter
• New Publication: CDC Grand Rounds: Newborn Screening and Improved Outcomes. Centers for Disease Control and Prevention (CDC). MMWR Morb Mortal Wkly Rep. 2012 Jun 1;61:390-3.
• Genomics, Epidemiology and Cancer: Where are we Going?
  • Frontiers in Cancer Epidemiology: A Challenge to the Research Community from the  Epidemiology and Genomics Research Program at the National Cancer Institute
    Khoury MJ, et al. Cancer Epidemiol Biomarkers Prev 2012 Jun
  • Cancer Epidemiology Matters Blog: What Scientific Questions Should Cancer Epidemiology Address in the Next Decade to Impact Public Health?

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Topics of the Week

Cancer

• Whole-genome analysis informs breast caner response to aromatase inhibition
  Ellis MJ, Ding L, Shen D, et al. Nature 2012 Jun 10

  • Scientists decode DNA to find breast tumor signatures that predict treatment response, Medical Xpress, June 10

  Clinical utility of gene-expression profiling for tumor-site origin in patients with metastatic or poorly differentiated cancer: impact on diagnosis, treatment,  and survival
  Nystrom SJ, et al. Oncotarget 2012 Jun

• Causes of death of mutation carriers in Finnish Lynch syndrome families
  Pylvanainen K, et al. Fam Cancer 2012 Jun

• Estimating Survival Rates after Ovarian Cancer Among Women Tested for BRCA1 and BRCA2 Mutations
  Narod SA, et al. Clin Genet 2012 Jun;9999(999A)

• Cancer Genomics Best Practices for Connecticut Healthcare Providers [PDF 7.80 MB], Connecticut Department of Public Health, Genomics Office, 2012

  • UConn health center genetic counselors make the rounds, University of Connecticut, June 7

Family History

• Family history influences the early onset of hepatocellular carcinoma
  Park CH, et al. World J Gastroenterol 2012 Jun;18(21):2661-7

• Maternal Family History is Associated with Alzheimer's Disease Biomarkers
  Honea RA, et al. J Alzheimers Dis 2012 Jun

• A review of family history of cardiovascular disease: risk factor and research tool.
  Banerjee A. Int J Clin Pract. 2012 Jun;66(6):536-43.

Genetic Testing in Practice

• An urgent need for a change in policy revealed by a study on prenatal testing for Duchenne muscular dystrophy
  Helderman-van den Enden AT, et al. Eur J Hum Genet 2012 Jun

• Cardiac channel molecular autopsy: insights from 173 consecutive cases of autopsy-negative sudden unexplained death referred for postmortem genetic testing
  Tester DJ, et al. Mayo Clin Proc 2012 Jun;87(6):524-39

• Challenges in and Principles for Conducting Systematic Reviews of Genetic Tests used as Predictive Indicators
  Jonas DE, et al. J Gen Intern Med 2012 Jun;27 Suppl 1:83-93

• The evolution of prenatal screening and diagnosis and its impact on an unselected population over an 18-year period
  Boyd P, et al. BJOG 2012 Jun

• The Ultimate Genetic Test
  Drmanac R. Science 2012 Jun 1 336(6085)1110-1112

• Exploratory planning and implementation of a pilot pharmacogenetic program in a community pharmacy
  O'Connor SK, et al. Pharmacogenomics 2012 Jun;13(8):955-62

• Whole-Genome Sequencing: The New Standard of Care?
  Brunham L, Hayede M. Science 2012 Jun 1 336(6085) 1112-1113

Newborn Screening

• Cost-effectiveness analysis of universal newborn screening for medium chain acyl-CoA dehydrogenase deficiency in France
  Hamers FF & Rumeau-Pichon C BMC Pediatr 2012 Jun;12(1):60

• Cases of Congenital Adrenal Hyperplasia Missed by Newborn Screening in Minnesota
  Sarafoglou K, Banks K, Kyllo J, et al. JAMA. 2012;307(22):2371-2374

  • Newborn screening may miss Adrenal-Gland disorder, Health Day, June 12

Guidelines and Recommendations

• The UK NEQAS for Molecular Genetics scheme for gastrointestinal stromal tumour: findings and recommendations following four rounds of circulation
  Wong NA, et al. J Clin Pathol 2012 Jun

Obesity

• Obesity Susceptibility Loci on Body Mass Index and Weight Loss in Spanish Adolescents after a Lifestyle Intervention
  Moleres A, et al. J Pediatr 2012 May

  • Predicting Weight Loss of Obese Adolescents in Lifestyle Interventions by Genetic Screening: A Promising Approach for Researchers and Clinicians?
    Reinehr T J Pediatr 2012 Jun

Public Health Sciences

• Return of research results from pharmacogenomic versus disease susceptibility studies: what's drugs got to do with it?
  Dressler LG Pharmacogenomics 2012 Jun;13(8):935-49

• Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study
  Dumitrescu L, et al. Hum Genet 2012 Jun

Funding

• Research Education Grants for Statistical and Computational Training in the Genetics of Addiction (R25)

• OMICS” Technologies For Predictive Modeling of Infectious Diseases (U19)

• PCORI Funding Announcements: Mandatory Letters of Intent (LOI) for the first cycle of funding are due June 15, and applications are due July 31.
  Research funds available for Assessment of Prevention, Diagnosis, and Treatment Options [PDF 701.24 KB]; Improving Healthcare Systems [PDF 693.31 KB]; Communication and Dissemination Research [PDF 687.62 KB] and Addressing Disparities [PDF 689.49 KB]

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CDC-Authored Genomics Publications

CDC authors are indicated in bold

View previous CDC-authored publications

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