Genomics & Health Impact Update

Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science.  To receive this update electronically every week sign-up here.

Thursday, June 7, 2012       Volume 28   Number 23

Spotlight

Genomics, Epidemiology and Cancer: Where are we Going?

New publication: Frontiers in Cancer Epidemiology: A Challenge to the Research Community from the  Epidemiology and Genomics Research Program at the National Cancer Institute
Khoury MJ, et al. Cancer Epidemiol Biomarkers Prev 2012 Jun

• Cancer Epidemiology Matters Blog: What Scientific Questions Should Cancer Epidemiology Address in the Next Decade to Impact Public Health?
• Why Hasn't Genomic Testing Changed the Landscape in Clinical Oncology? [PDF 71.56KB]
  Hayes DF, Khoury MJ, Ransohoff D. ASCO 2012 Educational Book e52-55.
• Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans.
  Boffetta P, Winn DM, Ioannidis JP, et al. Int J Epidemiol. 2012 May 16.
• Blog on gene-environment interaction: Shall we have pie or stew?
• Genetic epidemiology with a capital E, ten years after.
  Khoury MJ, Gwinn M, Clyne M, Yu W. Genet Epidemiol 2011 Dec;35(8):845-52

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Genomic Pulse

• Since 2001, there have been more than 15,000 articles published on the relationship between genetic variations and various cancers, including 263 genomewide association studies and 961 meta analyses of specific genes. Since 2009, 272 genomic tests have been identified for cancer treatment and prevention. To find out more, please visit the CancerGEM Knowledge Base website

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Announcements

• New: CDC Public Health Genomics 2012 At a Glance: Realizing Opportunities for Genomics to Improve Health
• CDC Grand Rounds: Newborn Screening and Improved Outcomes. Centers for Disease Control and Prevention (CDC). MMWR Morb Mortal Wkly Rep. 2012 Jun 1;61:390-3.
• New Publications: National Institutes of Health Approaches to Dissemination and Implementation Science: Current and Future Directions.
  Glasgow RE, Vinson C, Chambers D, Khoury MJ, et al. Am J Public Health. 2012 May 17.
• Tourette Syndrome Awareness Month is May 15 through June 15
  • Overcoming the odds, CDC Feature
  • Is Tourette syndrome inherited? Fact sheet from the National Institute of Neurological Disorders and Stroke
  • Check out genes associated with Tourette Syndrome in Phenopedia of the HuGE Navigator

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Topics of the Week

Cancer

• Multisite Validation Study To Determine Performance Characteristics of a 92-gene  Molecular Cancer Classifier
  Kerr SE, et al. Clin Cancer Res 2012 May

• Cost sharing and hereditary cancer risk: Predictors of willingness-to-pay for genetic testing.
  Matro J, Ruth K, Wong Y, et al. J Clin Oncol 30, 2012 (suppl; abstr 1544)

  • Not all patients will pay for genetic testing, study suggests, Science Daily, June 1

• Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA.
  Forshew T, Murtaza M, Parkinson C, et al. Sci Transl Med. 2012 May 30;4(136):136ra68.

  • Detecting cancers -- from tiny bits of tumor DNA in blood, The Los Angeles Times, May 30

Cardiovascular Disease

• Folate Network Genetic Variation Predicts Cardiovascular Disease Risk in Non-Hispanic White Males
  Wernimont SM, et al. J Nutr 2012 May

Guidelines and Recommendations

• ESHRE PGD consortium best practice guidelines for organization of a PGD centre for PGD/preimplantation genetic screening  
  Harton G, et al. Hum Reprod 2012 Jun

Obesity

• Polygenic Risk, Rapid Childhood Growth, and the Development of Obesity: Evidence  From a 4-Decade Longitudinal StudyPolygenic Risk for Adult Obesity
  Belsky DW, et al. Arch Pediatr Adolesc Med 2012 Jun;166(6):515-21

  • Translating Developmental Genetic Findings Into Obesity-Related Clinical Practice: Are We There Yet?
    Fernandez J. Arch Pediatr Adolesc Med. 2012;166(6):576-577
  • Genetics, rapid childhood growth and the development of obesity, EurekAlert, June 4

Smoking Cessation

• Interplay of Genetic Risk Factors (CHRNA5-CHRNA3-CHRNB4) and Cessation Treatments in Smoking Cessation Success.
  Chen LS, Baker TB, Piper ME, et al. Am J Psychiatry. 2012 May 30.

  • Genes predict if medication can help you quit smoking, Science Daily, May 30
  • Odds of quitting smoking affected by genetics, NIH News, May 30

Public Health Sciences

• APOE {varepsilon}4 Status and Traumatic Brain Injury on the Gridiron or the Battlefield.
  Gandy S, Dekosky ST. Sci Transl Med. 2012 May 16;4(134):134ed4.

  • A call to consider genetic testing for young athletes, NewsPlex, June 4

• The 1000 Genomes Project: data management and community access.
  Clarke L, Zheng-Bradley X, Smith R, et al. Nat Methods. 2012 Apr 27;9(5):459-462.

Whole-Genome Sequencing

• Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives.
  Postmus I, Verschuren JJ, de Craen AJ, et al. Pharmacogenomics. 2012 May;13(7):831-40.

• Noninvasive Whole-Genome Sequencing of a Human Fetus
  Kitzman J, Snyder M, Ventura M, et al. Sci Transl Med 6 June 2012: Vol. 4, Issue 137, p. 137ra76

  • Baby's genome deciphered prenatally from parents' lab tests, Science Daily, June 6
  • DNA blueprint for fetus built using tests of parents, The New York Times, June 6

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CDC-Authored Genomics Publications

CDC authors are indicated in bold

View previous CDC-authored publications

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