Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science. To receive this update electronically every week sign-up here.
Monday, July 2, 2012 Volume 29 Number 1
Happy 4th of July
- Collect your family health history with My Family Health Portrait from the Surgeon General
- Send out a Family History eCard to someone special.
Over a million people in the U.S. are predisposed to serious health problems and premature death due to Lynch syndrome, familial hypercholesterolemia, or BRCA-associated hereditary breast and ovarian cancer. For each affected person found, many at-risk relatives could be identified who could benefit from evidence-based interventions to improve their health. To find out more about tier 1 genomic applications, please click here
Follow Dr. Khoury on Twitter
- Find out more about #P4medicine https://m360.washbio.org/event.aspx?eventID=50715 and how public health http://www.ncbi.nlm.nih.gov/pubmed/22608383 can help make it succeed
- RT @DrGrantCDC Learn about #sicklecelltrait from this month's webinar with Dr Laretta Jordan, June 28, 2pm http://go.usa.gov/ybA
- Blog Post: Peeling the pyramid, scaling the onion—how to implement genomic medicine
- National HIV Testing Day, June 27
- CDC feature: Cancer and Men
- Know your family health history: it can save your life
- Genetics and prostate cancer (from the National Cancer Institute)
- CDC feature: Sickle Cell Awareness
Perceptions of genetic research and testing among members of families with an increased risk of malignant melanoma
Branstrom R, et al. Eur J Cancer 2012 Jun
Shorter telomere length is associated with increased ovarian cancer risk in both familial and sporadic cases, Medscape, June 26 [by free subscription only]
Familial Aggregation of Lone Atrial Fibrillation in Young Persons
Oyen N, et al. J Am Coll Cardiol 2012 Jun
Genetic Testing in Practice
A Report Template for Molecular Genetic Tests Designed to Improve Communication Between the Clinician and Laboratory
Scheuner MT, et al. Genet Test Mol Biomarkers 2012 Jun
Awareness and Uptake of Direct-to-Consumer Genetic Testing Among Cancer Cases, Their Relatives, and Controls: The Northwest Cancer Genetics Network
Hall TO, et al. Genet Test Mol Biomarkers 2012 Jun
Improvement of interpretation in cystic fibrosis clinical laboratory reports: longitudinal analysis of external quality assessment data
Berwouts S, et al. Eur J Hum Genet 2012 Jun
Exome sequencing is an efficient tool for genetic screening of Charcot-Marie-Tooth disease
Choi BO, et al. Hum Mutat 2012 Jun
To Know or Not to Know: An Update of the Literature on the Psychological and Behavioral Impact of Genetic Testing for Alzheimer Disease Risk
Rahman B, et al. Genet Test Mol Biomarkers 2012 Jun
Preoperative Diagnosis of Benign Thyroid Nodules with Indeterminate Cytology.
Alexander EK, Kennedy GC, Baloch ZW, et al. N Engl J Med. 2012 Jun 25.
Minimizing Unnecessary Surgery for Thyroid Nodules.
Jameson JL. N Engl J Med. 2012 Jun 25.
- Low-risk thyroid nodules identified by gene expression test, Medical News Today, June 27
- Providing Appropriate Genetic Information to Healthy Carriers of Hemoglobinopathy Can Be a Welcome and Safe Initiative: The Latium Example
Amato A, et al. Genet Test Mol Biomarkers 2012 Jun
Standardized Procedural Practices of the Ontario Prenatal Screening Program for aneuploidies and open neural tube defects
Lepage N, et al. Clin Biochem 2012 Jun
Parents: Critical Stakeholders in Expanding Newborn Screening
Friedman Ross L, Waggoner D. Journal of Pediatrics 2012 Jun 25
Informed consent for newborn screening? Medical News Today, June 22
Public Health Sciences
Multiple comparisons of drug efficacy between subgroups defined by genetic polymorphisms
Tu YH & Hsu JC Stat Med 2012 Jun
Genome-wide Transcriptome Profiling Reveals the Functional Impact of Rare De Novo and Recurrent CNVs in Autism Spectrum Disorders
Lou R, Sanders S, Tian Y, et al. American Journal of Human Genetics 2012 Jun 21
Study uncovers new tools for targeting genes linked to autism, Medical News Today, June 24
Cigarette smoke-induced transgenerational alterations in genome stability in cord blood of human F1 offspring
Laubenthal J, Zlobinskaya O, Poterlowicz K, et al. FASEB Journal 2012 Jun 22
Another reason why dads and hopeful dads should quit smoking now, Science Daily, June 23
CDC authors are indicated in bold
Genetic characterization of Cryptosporidium spp. in diarrhoeic children from four provinces in South Africa
Abu Samra N, Thompson PN, Jori F, Frean J, Poonsamy B, du Plessis D, Mogoye B, Xiao L. Zoonoses Public Health. 2012 Jun 20.
Nocardia amikacinitolerans sp. nov., an amikacin-resistant human pathogen
Ezeoke I, Klenk HP, Potter G, Schumann P, Moser BD, Lasker BA, Nicholson A, Brown JM. Int J Syst Evol Microbiol. 2012 Jun 15.
Cancer in children with nonchromosomal birth defects
Fisher PG, Reynolds P, Von Behren J, Carmichael SL, Rasmussen SA, Shaw GM. J Pediatr. 2012 Jun;160(6):978-83.
Differential association of gene content polymorphisms of killer cell immunoglobulin-like receptors with placental malaria in HIV- and HIV+ mothers
Omosun YO, Blackstock AJ, Gatei W, Hightower A, van Eijk AM, Ayisi J, Otieno J, Lal RB, Steketee R, Nahlen B, Ter Kuile FO, Slutsker L, Shi YP. PLoS One. 2012 ;7(6):e38617.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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