Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update offers links to genomics news and publications relevant to population health and health care. The Update highlights family health history and genomic tests, along with relevant data, policy, and legislation. Please send your comments to: firstname.lastname@example.org.
Thursday, January 26, 2012 Volume 28 Number 4
The 23rd Meeting of the EGAPP Working Group will be held in Atlanta on January 30-31st, 2012. The Working Group will be welcoming four new members: Dr. Jonathan Berg, Dr. Cecile Janssens, Dr. Marc Williams, and Dr. Doris Zallen.
**More at www.egappreviews.org**
New report: Building on our inheritance: Genomic technology in healthcare [PDF 824.29 KB], by the Human Genomics Strategy Group in the UK
A new publication from the CDC-sponsored Family Healthware Impact Trial: Health beliefs among individuals at increased familial risk for type 2 diabetes: Implications for prevention. Dorman JS, Valdez R, Liu T, Wang C, Rubinstein WS, O'Neill SM, Acheson LS, Ruffin MT 4th, Khoury MJ. Diabetes Res Clin Pract. 2012 Jan 16. Read more about Family Healthware
Clinical utility gene card for: Werner syndrome
Hisama FM, et al. Eur J Hum Genet 2012 Jan
Microarray application in prenatal diagnosis: a position statement from the cytogenetics working group on behalf of the Italian Society of Human Genetics (SIGU), November 2011
Novelli A, et al. Ultrasound Obstet Gynecol 2012 Jan
Health beliefs among individuals at increased familial risk for type 2 diabetes: Implications for prevention
Dorman JS, et al. Diabetes Res Clin Pract 2012 Jan
Impact of Colon Cancer Screening on Family History Phenotype
Newcomb PA, et al. Epidemiology 2012 Jan
The Use of a Family History Risk Assessment Tool within a Community Health Care System: Views of Primary Care Providers
Christianson CA, et al. J Genet Couns 2012 Jan
The family tree, News Times, January 24
Consolidating newborn screening efforts in the Asia Pacific region : Networking and shared education
Padilla CD & Therrell BL Jr J Community Genet 2012 Jan
Knowledge, attitudes and education of pharmacists regarding pharmacogenetic testing, Medcape, January 24
Charting ELSI's future course: lessons from the recent past
Walker RL & Morrissey C Genet Med 2012 Jan
The role of disease characteristics in the ethical debate on personal genome testing
Bunnik EM, et al. BMC Med Genomics 2012 Jan;5(1):4
Effect of genetic testing for risk of type 2 diabetes mellitus on health behaviors and outcomes: Study rationale, development, and design
Cho AH, et al. BMC Health Serv Res 2012 Jan;12(1):16
Offering aggregate results to participants in genomic research: opportunities and challenges
Beskow LM, et al. Genet Med 2012 Jan
Racial and Ethnic Differences in Direct-to-Consumer Genetic Tests Awareness in HINTS 2007: Sociodemographic and Numeracy Correlates
Langford AT, et al. J Genet Couns 2012 Jan
Rare and common variants: twenty arguments.
Gibson G. Nat Rev Genet. 2012 Jan 18;13(2):135-45
Genetic abnormality predicts treatment benefit for patients with rare brain tumor, NCI Cancer Bulletin, January 24
Genetic contributions to stability and change in intelligence from childhood to old age.
Deary IJ, Yang J, Davies G, et al. Nature. 2012 Jan 18.
Genes may help brains age better, PHG Foundation, January 24
Life-long intelligence in the genes, Nature News, January 24
Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics
Devlin A, Ngai Y, Ronsley R, et al. Translational Psychiatry (2012) 2, e71
Genetic variation increases risk of metabolic side effects in children on some antipsychotics, EurekAlert, January 24
Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer
Bolton K, Chenevix-Trench G, Goh C, et al. JAMA 2012; 307(4):382-389
Breast Cancer Prognosis in BRCA1 and BRCA2 Mutation Carriers: An International Prospective Breast Cancer Family Registry Population-Based Cohort Study.
Goodwin PJ, Phillips KA, West DW, et al. J Clin Oncol. 2012 Jan 1;30(1):19-26.
Ovarian cancer patients with BRCA mutations may fare better than non-carriers, NCI Cancer Bulletin, January 24
Women with certain type of ovarian cancer and BRCA gene mutation have improved survival at 5 years, Science Daily, January 24
Does a BRCA mutation influence breast cancer outcomes? Medscape, January 20
Discovery of common variants associated with low TSH levels and thyroid cancer risk.
Gudmundsson J, Sulem P, Gudbjartsson DF, et al. Nat Genet. 2012 Jan 22.
Decode-led team tracks down thyroid cancer related variants, Genome Web, January 23 [by free subscription only]
Genome-wide association analysis identifies three new breast cancer susceptibility loci.
Ghoussaini M, Fletcher O, Michailidou K, et al. Nat Genet. 2012 Jan 22.
Large analysis leads to three new breast cancer risk loci, Genome Web, January 23 [by free subscription only]
Genetic Signatures of Exceptional Longevity in Humans
Sebastiani P, Solovieff N, DeWan AT, Walsh KM, Puca A, et al. (2012) PLoS ONE 7(1): e29848.
Link between genetic variants and extreme old age confirmed, PHG Foundation, January 22
Long life is still (somewhat) in your genes, Science, January 20
Association between Tumor Epidermal Growth Factor Receptor Mutation and Pulmonary Tuberculosis in Patients with Adenocarcinoma of the Lungs.
Luo YH, Wu CH, Wu WS, et al. J Thorac Oncol. 2012 Feb;7(2):299-305.
TB and a gene mutation that causes lung cancer linked, Medical News Today, January 19
CDC authors are indicated in bold
Neuraminidase H275Y and hemagglutinin D222G mutations in a fatal case of 2009 pandemic influenza A (H1N1) virus infection
Devries A, Wotton J, Lees C, Boxrud D, Uyeki T, Lynfield R.
Influenza Other Respi Viruses. 2012 Jan 14.
Pertussis pseudo-outbreak linked to specimens contaminated by Bordetella pertussis DNA from clinic surfaces
Mandal S, Tatti KM, Woods-Stout D, Cassiday PK, Faulkner AE, Griffith MM, Jackson ML, Pawloski LC, Wagner B, Barnes M, Cohn AC, Gershman KA, Messonnier NE, Clark TA, Tondella ML, Martin SW.
Pediatrics. 2012 Jan 16.
It's Time for Gene Therapy to Get Disruptive!
Wilson JM. Hum Gene Ther. 2012 Jan;23(1):1-3.
Gene therapy is a 'disruptive science' ready for commercial development, EurekAlert, January 24
Gene Silencing by Small RNAs
February 7-12 ~ Vancouver, Canada
US HUPO from genes to function
March 4-7 ~ San Francisco, CA
Biomarker Summmit 2012
March 15-16 ~ San Diego, CA
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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