Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update offers links to genomics news and publications relevant to population health and health care. The Update highlights family health history and genomic tests, along with relevant data, policy, and legislation. Please send your comments to: firstname.lastname@example.org.
Thursday, January 5, 2012 Volume 28 Number 1
New CDC Feature: A New Year of Healthy Possibilities!
"Make being healthy your resolution. Stay healthy this year. Tips focus on a healthy you, family, home, community, and workplace. This includes gathering and sharing your family health history.”
- Cancer Program Standards 2012: Ensuring Patient-Centered Care [PDF 3.58 MB] from the American College of Surgeons includes new standards for Risk Assessment and Genetic Counseling.
- New Publication: Using Core Public Health Functions to Promote BRCA Best Practices among Health Plans
Duquette D, et al. Public Health Genomics 2011 Dec.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype
Crews KR, et al. Clin Pharmacol Ther 2011 Dec
Validation of KRAS Testing for Anti-EGFR Therapeutic Decisions for Patients With Metastatic Colorectal Carcinoma
Kamel-Reid S, et al. Arch Pathol Lab Med 2012 Jan;136(1):26-32
CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis.
Holmes MV, Perel P, Shah T, et al. JAMA. 2011 Dec 28;306(24):2704-14.
Pharmacogenomics and Clopidogrel
Nissen S. JAMA 2011;306(24):2727-2728
Analysis does not support genetic test before use of anti-clotting drug, EurekAlert, December 27
Factors affecting frequency of communication about family health history with family members and doctors in a medically underserved population
Kaphingst KA, et al. Patient Educ Couns 2011 Dec
Potential prevention of thromboembolism by genetic counseling and testing for two common thrombophilia mutations
Yapijakis C, et al. In Vivo 2012 Jan;26(1):165-72
Correlates of Family Health History Discussions Between College Students and Physicians, Medscape, December 28 [by free subscription only]
Child health providers' precautionary discussion of emotions during communication about results of newborn genetic screening
Farrell MH, et al. Arch Pediatr Adolesc Med 2012 Jan;166(1):62-7
Educational Needs of Primary Care Physicians Regarding Direct-to-Consumer Genetic Testing
Powell KP, et al. J Genet Couns 2011 Dec
Health care providers and direct-to-consumer access and advertising of genetic testing in the United States
Myers MF Genome Med 2011 Dec;3(12):81
KRAS Mutations Testing in Colorectal Carcinoma Patients in Italy: From Guidelines to External Quality Assessment.
Normanno N , Pinto C , Castiglione F, et al. 2011 PLoS ONE 6(12): e29146.
Systematic Immunohistochemistry Screening for Lynch Syndrome in Early Age-of-Onset Colorectal Cancer Patients Undergoing Surgical Resection
Steinhagen E, Shia J, Markowitz AJ, et al. J Am Coll Surg. 2012 Jan;214(1):61-7.
Using Core Public Health Functions to Promote BRCA Best Practices among Health Plans
Duquette D, et al. Public Health Genomics 2011 Dec
Advancing care and awareness of sickle cell disease, The Washington Post, December 27
Newborn screening for lysosomal storage diseases: an ethical and policy analysis
Ross LF J Inherit Metab Dis 2011 Dec
Preconception care and genetic risk: ethical issues
De Wert GM, et al. J Community Genet 2011 Dec
A push to tie new drugs to testing, The New York Times, December 26
Balancing the Risks and Benefits of Genomic Data Sharing: Genome Research Participants' Perspectives
Oliver JM, et al. Public Health Genomics 2011 Dec
Biomarker classifiers for identifying susceptible subpopulations for treatment decisions
Lin WJ, Chen JJ. Pharmacogenomics. 2011 Dec 21.
Evaluating Phenotypic Data Elements for Genetics and Epidemiological Research: Experiences from the eMERGE and PhenX Network Projects
Pathak J, et al. AMIA Summits Transl Sci Proc 2011;2011:41-5
Gene-Environment Interactions in Genome-Wide Association Studies: A Comparative Study of Tests Applied to Empirical Studies of Type 2 Diabetes.
Cornelis MC, Tchetgen EJ, Liang L, et al. Am J Epidemiol. 2011 Dec 22.
Genetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathways
Olgiati P, et al. Int J Alzheimers Dis 2011;2011:832379
Informed Choice in Direct-to-Consumer Genetic Testing (DTCGT) Websites: A Content Analysis of Benefits, Risks, and Limitations
Singleton A, et al. J Genet Couns 2011 Dec
Perceptions About Genetic Testing for the Susceptibility to Alcohol Dependence and Other Multifactorial Diseases
Marshall VJ, et al. Genet Test Mol Biomarkers 2011 Dec
The vaccine adverse event reporting system and vaccine safety research in the genomics era.
Davis RL. Vaccine. 2011 Dec 14.
Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG).
Jin G, Lu L, Cooney KA, Ray AM, et al. Hum Genet. 2011 Dec 25.
CHEK2*1100delC homozygosity is associated with a high breast cancer risk in women.
Adank MA, Jonker MA, Kluijt I, et al. J Med Genet. 2011 Dec;48(12):860-3. Epub 2011 Nov 5.
CHEK2*1100delC homozygosity is associated with a high breast cancer risk in women, Medscape, January 3 [by free subscription only]
Recurrent Somatic DICER1 Mutations in Nonepithelial Ovarian Cancers.
Heravi-Moussavi A, Anglesio MS, Cheng SW, et al. N Engl J Med. 2011 Dec 21.
Gene links rare and unrelated cancers, Medical News Today, January 2
Genome-wide detection of natural selection in African Americans pre-and post-admixture
Jin W, Xu S, Wang H, et al. Genome Res. 2011 Dec 28.
Genome study points to adaptation in early African-Americans, The New York Times, January 2
Pharmacogenomics and personalized medicine: the plunge into next-generation sequencing
Wadelius M & Alfirevic A Genome Med 2011 Dec;3(12):78
Are diabetes and colorectal cancer risk genetically linked? Medscape, January 3 [by free subscription only]
Whole genome sequences of a male and female supercentenarian, ages greater than 114 years
Sebastiani P, Riva A, Montano M, et al. Front. Gene. 2012 Jan 3; 2:90.
Genetic predisposition to disease common in 2 supercentenarians: New study, EurekAlert, January 3
$9.5 Million federal grant to support "Asthma Genome" project with African-Americans, Medical News Today, December 30
NHGRI to fund new Africa genomics grants, biorepositories, Genome Web, December 23
NIH establishes National Center for Advancing Translational Sciences, NIH News, December 23
NIH launches first online genetics course for social and behavioral scientists, NIH News, January 3
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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