Genomics & Health Impact Update

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype
Crews KR, et al. Clin Pharmacol Ther 2011 Dec

Validation of KRAS Testing for Anti-EGFR Therapeutic Decisions for Patients With  Metastatic Colorectal Carcinoma
Kamel-Reid S, et al. Arch Pathol Lab Med 2012 Jan;136(1):26-32

CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis.
Holmes MV, Perel P, Shah T, et al. JAMA. 2011 Dec 28;306(24):2704-14.

Pharmacogenomics and Clopidogrel
Nissen S. JAMA 2011;306(24):2727-2728

Analysis does not support genetic test before use of anti-clotting drug, EurekAlert, December 27

Factors affecting frequency of communication about family health history with family members and doctors in a medically underserved population
Kaphingst KA, et al. Patient Educ Couns 2011 Dec

Potential prevention of thromboembolism by genetic counseling and testing for two common thrombophilia mutations
Yapijakis C, et al. In Vivo 2012 Jan;26(1):165-72

Correlates of Family Health History Discussions Between College Students and Physicians, Medscape, December 28 [by free subscription only]

Child health providers' precautionary discussion of emotions during communication about results of newborn genetic screening
Farrell MH, et al. Arch Pediatr Adolesc Med 2012 Jan;166(1):62-7

Educational Needs of Primary Care Physicians Regarding Direct-to-Consumer Genetic Testing
Powell KP, et al. J Genet Couns 2011 Dec

Health care providers and direct-to-consumer access and advertising of genetic testing in the United States
Myers MF Genome Med 2011 Dec;3(12):81

KRAS Mutations Testing in Colorectal Carcinoma Patients in Italy: From Guidelines to External Quality Assessment.
Normanno N , Pinto C , Castiglione F, et al. 2011 PLoS ONE 6(12): e29146.

Systematic Immunohistochemistry Screening for Lynch Syndrome in Early Age-of-Onset Colorectal Cancer Patients Undergoing Surgical Resection
Steinhagen E, Shia J, Markowitz AJ, et al. J Am Coll Surg. 2012 Jan;214(1):61-7.

Using Core Public Health Functions to Promote BRCA Best Practices among Health Plans
Duquette D, et al. Public Health Genomics 2011 Dec

Advancing care and awareness of sickle cell disease, The Washington Post, December 27

Newborn screening for lysosomal storage diseases: an ethical and policy analysis
Ross LF J Inherit Metab Dis 2011 Dec

Preconception care and genetic risk: ethical issues
De Wert GM, et al. J Community Genet 2011 Dec

A push to tie new drugs to testing, The New York Times, December 26

Balancing the Risks and Benefits of Genomic Data Sharing: Genome Research Participants' Perspectives
Oliver JM, et al. Public Health Genomics 2011 Dec

Biomarker classifiers for identifying susceptible subpopulations for treatment decisions
Lin WJ, Chen JJ. Pharmacogenomics. 2011 Dec 21.​‌

Evaluating Phenotypic Data Elements for Genetics and Epidemiological Research: Experiences from the eMERGE and PhenX Network Projects
Pathak J, et al. AMIA Summits Transl Sci Proc 2011;2011:41-5

Gene-Environment Interactions in Genome-Wide Association Studies: A Comparative Study of Tests Applied to Empirical Studies of Type 2 Diabetes.
Cornelis MC, Tchetgen  EJ, Liang L, et al. Am J Epidemiol. 2011 Dec 22.

Genetics of late-onset Alzheimer's disease: update from the alzgene database and  analysis of shared pathways
Olgiati P, et al. Int J Alzheimers Dis 2011;2011:832379

Informed Choice in Direct-to-Consumer Genetic Testing (DTCGT) Websites: A Content Analysis of Benefits, Risks, and Limitations
Singleton A, et al. J Genet Couns 2011 Dec

Perceptions About Genetic Testing for the Susceptibility to Alcohol Dependence and Other Multifactorial Diseases
Marshall VJ, et al. Genet Test Mol Biomarkers 2011 Dec

The vaccine adverse event reporting system and vaccine safety research in the genomics era.
Davis RL. Vaccine. 2011 Dec 14.

Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG).
Jin G, Lu L, Cooney KA, Ray AM, et al. Hum Genet. 2011 Dec 25.

CHEK2*1100delC homozygosity is associated with a high breast cancer risk in women.
Adank MA, Jonker MA, Kluijt I, et al. J Med Genet. 2011 Dec;48(12):860-3. Epub 2011 Nov 5.

CHEK2*1100delC homozygosity is associated with a high breast cancer risk in women, Medscape, January 3 [by free subscription only]

Recurrent Somatic DICER1 Mutations in Nonepithelial Ovarian Cancers.
Heravi-Moussavi A, Anglesio MS, Cheng SW, et al. N Engl J Med. 2011 Dec 21.

Gene links rare and unrelated cancers, Medical News Today, January 2

Genome-wide detection of natural selection in African Americans pre-and post-admixture
Jin W, Xu S, Wang H, et al. Genome Res. 2011 Dec 28.

Genome study points to adaptation in early African-Americans, The New York Times, January 2

Pharmacogenomics and personalized medicine: the plunge into next-generation sequencing
Wadelius M & Alfirevic A Genome Med 2011 Dec;3(12):78

Are diabetes and colorectal cancer risk genetically linked? Medscape, January 3 [by free subscription only]

Whole genome sequences of a male and female supercentenarian, ages greater than 114 years
Sebastiani P, Riva A, Montano M, et al. Front. Gene. 2012 Jan 3; 2:90.

Genetic predisposition to disease common in 2 supercentenarians: New study, EurekAlert, January 3

$9.5 Million federal grant to support "Asthma Genome" project with African-Americans, Medical News Today, December 30

VA wants to collect clinical laboratory blood specimens from one million veterans to create world’s largest medical database and gene repository, Dark Daily, December 28

NHGRI to fund new Africa genomics grants, biorepositories, Genome Web, December 23

NIH establishes National Center for Advancing Translational Sciences, NIH News, December 23

NIH launches first online genetics course for social and behavioral scientists, NIH News, January 3