 For information on genomic applications in cancer care and prevention, please visit the CancerGEM Knowledge Base |
Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update offers links to genomics news and publications relevant to population health and health care. The Update highlights family health history and genomic tests, along with relevant data, policy, and legislation. Please send your comments to: genetics@cdc.gov.
Thursday, February 23, 2012 Volume 28 Number 8
Spotlight
Family History in Primary Care
- New Blog Post: Emerging Evidence for the Benefits of Systematic Collection of Family History in Primary Care
- New Publication: Effect of Adding Systematic Family History Enquiry to Cardiovascular Disease Risk Assessment in Primary Care: A Matched-Pair, Cluster Randomized Trial
Qureshi N, et al. Ann Intern Med 2012 Feb;156(4):253-62 - Family history gets a boost
Berg AO Ann Intern Med 2012 Feb;156(4):315-6
- Does routinely assessing family history improve detection of patients at high risk for cardiovascular disease?
Ann Intern Med 2012 Feb;156(4):I38 - Family history -- a significant way to improve cardiovascular disease risk assessment, Medical Press, February 22
Announcements
- New Publication: Estimating the contribution of genetic variants to difference in incidence of disease between population groups
Moonesinghe R, Ioannidis JP, Flanders WD, Yang Q, Truman BI, Khoury MJ. Eur J Hum Genet. 2012 Feb 15. - February is American Heart Month: Be One in a Million this American Heart Month and Wear Red for a Million Hearts, CDC Features
- Read the Blog Post "A Million Hearts, A Thousand Genes, and Your Family History"
Topics
Genomic Tests
Mass Gen begins study on depression treatment response using genetic biomarker data, Genome Web, February 16 [by free subscription only]
For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base and PLoS Currents Evidence on Genomic Tests.
Family Health History
A clinically confirmed family history for early myocardial infarction is associated with increased risk of obesity, insulin resistance and metabolic syndrome
Magnusson M, et al. J Hypertens 2012 Feb
Cancer genetic risk assessment for individuals at risk of familial breast cancer
Hilgart JS, et al. Cochrane Database Syst Rev 2012;2:CD003721
Family history and risk of breast cancer: nurses' health study
Colditz GA, et al. Breast Cancer Res Treat 2012 Feb
Practice and Programs
Direct-to-consumer genomic testing: systematic review of the literature on user perspectives
Goldsmith L, et al. Eur J Hum Genet 2012 Feb
French women's breast self-examination practices with time after undergoing BRCA1/2 genetic testing
Maheu C, et al. Fam Cancer 2012 Feb
Predictive genetic testing of first degree relatives of mutation carriers is a cost-effective strategy in preventing hereditary non-polyposis colorectal cancer in Singapore
Wang VW, et al. Fam Cancer 2012 Feb
Routine Lynch Syndrome screening varies at U.S. cancer centers, NCI Cancer Bulletin, February 21
Policy and Legislation
Personalized medicine: Bring clinical standards to human-genetics research
Lyon GJ Nature 2012 Feb;482(7385):300-1
Court to consider gene patent, The Age, February 21
Supreme Court considering taking on gene patents case, Genome Web, February 20 [by free subscription only]
Can you be fired for your genes? Time, February 20
USPTO to hold hearing on genetic diagnostic testing, JDSUPRA, February 16
AMP testifies at USPTO [PDF 56.52 KB], AMP, February 16
Public Health Science
One thing leads to another: the cascade of obligations when researchers report genetic research results to study participants
Miller FA, et al. Eur J Hum Genet 2012 Feb
Association Between a Functional Polymorphism in the MAOA Gene and Sudden Infant Death Syndrome.
Klintschar M, Heimbold C. Pediatrics. 2012 Feb 20.
X-Chromosome gene variant linked to SIDS in boys, Medical Press, February 21
Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes
MacArthur D, Balasubramanian S, Frankish A, et al. Science 335(6070):823-828
When is a gene not a gene? New catalog helps identify gene variations associated with disease, Medical Press, February 16
Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women, Medscape, February 15
335 human genome epidemiology articles have recently been added, please visit the HuGE Literature Finder in the HuGE Navigator.
CDC-Authored Genomics Publications
CDC authors are indicated in bold
Estimating the contribution of genetic variants to difference in incidence of disease between population groups
Moonesinghe R, Ioannidis JP, Flanders WD, Yang Q, Truman BI, Khoury MJ. Eur J Hum Genet. 2012 Feb 15.
Looking back at genomic medicine in 2011
Auffray C, Caulfield T, Khoury MJ, Lupski JR, Schwab M, Veenstra T. Genome Med. 2012 Jan 30;4(1):9.
Trimethyltin-induced neurotoxicity: gene expression pathway analysis, q-RT-PCR and immunoblotting reveal early effects associated with hippocampal damage and gliosis
Little AR, Miller DB, Li S, Kashon ML, O'Callaghan JP. Neurotoxicol Teratol. 2012 Jan;34(1):72-82.
View previous CDC-authored publications
Let's Go Surfing
College students comfortable with biobanks, willing to donate genetic material for research, Medical News Today, February 22
New book ponders ethical issues of genetic testing, Medical Press, February 22
World's first miniature DNA sequencer unveiled, PHG Foundation, February 22
Company unveils DNA sequencing device meant to be portable, disposable and cheap, The New York Times, February 17
Events and Training
Rare Disease Day at NIH raises awareness and highlights cutting-edge research, NIH News, February 16
National Patient and Stakeholder Dialogue
February 27 ~ Washington, DC
From Population Health to Personal Health
April 17-20 ~ Rome, Italy
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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