 For information on genomic applications in cancer care and prevention, please visit the CancerGEM Knowledge Base |
Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update offers links to genomics news and publications relevant to population health and health care. The Update highlights family health history and genomic tests, along with relevant data, policy, and legislation. Please send your comments to: genetics@cdc.gov.
Thursday, February 9, 2012 Volume 28 Number 6
Spotlight
February is American Heart Month: Be One in a Million this American Heart Month and Wear Red for a Million Hearts, CDC Features
American Heart Month: Urge all to focus on family heart health, Enhanced Online News, February 2
- Read the Blog Post "A Million Hearts, A Thousand Genes, and Your Family History"
- Heart disease and family history
- CDC podcast on familial hypercholesterolemia
- Cascade Screening for Familial Hypercholesterolemia (FH), PLoS Currents: Evidence on Genomics Tests
- EGAPP recommendation on genomic profiling in risk assessment for heart disease
- CDC Director Dr. Tom Frieden talks about Million Hearts and Family History on the Dr. Oz Show
Announcements
- New Publication: Trends in Population-Based Studies of Human Genetics in Infectious Diseases
Rowell J, Dowling N, Yu W, Yesupriya A, Zhang L, Gwinn M, 2012 PLoS ONE 7(2): e25431 - The Ethics and Practice of Whole Genome Sequencing in the Clinic was one of the agenda items of the Presidential Commission for the Study of Bioethical Issues meeting on February 2-3:
- Agenda, Webcast and Blog Posts
- Also read: White House bioethics commission tackles genomic data, Genome Web, February 3 [by free subscription only]
- New report: Building on our inheritance: Genomic technology in healthcare [PDF 824.29 KB], by the Human Genomics Strategy Group in the UK
- Also read: Genomic medicine and the NHS: it is possible Lancet 2012 Feb;379(9814):386
Topics
Genomic Tests
DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as Down syndrome: an international collaborative study.
Palomaki GE, Deciu C, Kloza EM, et al. Genet Med. 2012 Jan 26.
DNA test that identifies Down syndrome in pregnancy can also detect trisomy 18 and trisomy 13, Medical Press, February 2
For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base and PLoS Currents Evidence on Genomic Tests.
Practice and Programs
Clopidogrel and Genetic Testing: Is it Necessary for Everyone?
Goswami S, et al. Cardiol Rev 2012 Jan
Direct-to-Consumer Personal Genomic Testing: A Case Study and Practical Recommendations for "Genomic Counseling"
Sturm AC & Manickam K J Genet Couns 2012 Feb
The ethical hazards and programmatic challenges of genomic newborn screening
Goldenberg AJ & Sharp RR JAMA 2012 Feb;307(5):461-2
APhA DrugInfoLine launches new pharmacogenomics section, Pharmacist, February 3
Policy and Legislation
EEOC issues final rule on Genetic Information Nondiscrimination Act records, Workforce, February 6
Legal Alert: Title VII record-keeping requirements extended to GINA, JD Supra, February 3
BRCA patent dispute may head to US Supreme Court.
Devi S. Lancet. 2012 Jan 28;379(9813):300.
End of BRCA patent dispute may be in sight, PHG Foundation, February 2
Public Health Science
Genetic Counseling as a Tool for Type 2 Diabetes Prevention: A Genetic Counseling Framework for Common Polygenetic Disorders
Waxler JL, et al. J Genet Couns 2012 Feb
Improved access to life insurance after genetic diagnosis of familial hypercholesterolaemia: cross-sectional postal questionnaire study
Huijgen R, et al. Eur J Hum Genet 2012 Feb
Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome
Charchar F, Bloomer L, Barnes T, et al. Lancet Feb 9
Male genes may explain higher heart disease risk, The New York Times, February 8
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
The International Stroke Genetics Consortium (ISGC); the Wellcome Trust Case Control Consortium 2 (WTCCC2), Bellenguez C, et al. Nat Genet. 2012 Feb 5.
Genetic variant increases risk of common type stroke, EurekAlert, February 5
Genome Research Feb 2012;2(2) special issue on cancer genomics
Cancer Genomics: Special issue published by Genome Research, Medical News Today, February 3
DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex
Numata S, Ye T, Hyde TM, Guitart-Navarro X, et al. Am J Hum Genet. 2012 Feb 1.
Gene regulator in brain's executive hub tracked across lifespan — NIH study, NIH News, February 2
205 human genome epidemiology articles have recently been added, please visit the HuGE Literature Finder in the HuGE Navigator.
CDC-Authored Genomics Publications
CDC authors are indicated in bold
The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents
Hallman DM, Friedel VC, Eissa MA, Boerwinkle E, Huber JC, Harrist RB, Srinivasan SR, Chen W, Dai S, Labarthe DR, Berenson GS. Int J Obes (Lond). 2012 Jan;36(1):61-8.
Genetic diversity and antibiotic resistance in Shigella dysenteriae and Shigella boydii strains isolated from children aged <5 years in Egypt
El-Gendy AM, Mansour A, Weiner MA, Pimentel G, Armstrong AW, Young SY, Elsayed N, Klena JD. Epidemiol Infect. 2012 Feb;140(2):299-310.
Genetic diversity of HA1 domain of hemagglutinin gene of pandemic influenza H1N1pdm09 viruses in New Delhi, India
Mir MA, Lal RB, Sullender W, Singh Y, Garten R, Krishnan A, Broor S. J Med Virol. 2012 Mar;84(3):386-93.
Permanent genetic resources added to Molecular Ecology Resources Database 1 October 2011 - 30 November 2011
Molecular Ecology Resources Primer Development Consortium , Abreu AG, Albaina A, Alpermann TJ, Apkenas VE, Bankhead-Dronnet S, Bergek S, Berumen ML, Cho CH, Clobert J, Coulon A, D. E. Feraudy D, Estonba A, Hankeln T, Hochkirch A, Hsu TW, Huang TJ, Irigoien X, Iriondo M, Kay KM, Kinitz T, Kothera L, L. E. Henanff M, Lieutier F, Lourdais O, Macrini CM, Manzano C, Martin C, Morris VR, Nanninga G, Pardo MA, Plieske J, Pointeau S, Prestegaard T, Quack M, Richard M, Savage HM, Schwarcz KD, Shade J, Simms EL, Solferini VN, Stevens VM, Veith M, Wen MJ, Wicker F, Yost JM, Zarraonaindia I. Mol Ecol Resour. 2012 Feb 1.
Trends in Population-Based Studies of Human Genetics in Infectious Diseases
Rowell J, Dowling N, Yu W, Yesupriya A, Zhang L, Gwinn M,
2012 PLoS ONE 7(2): e25431
View previous CDC-authored publications
Let's Go Surfing
The myth of the genomic revolution, Bio News, February 6
Events and Training
Rare Disease Day
February 29 ~ Washington, DC
Genetic Testing and Data Management Summit
March 12 ~ Washington, DC
2012 Epigenetics Workshop
March 13 ~ Boston MA
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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