Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science. To receive this update electronically every week sign-up here.
Thursday, December 13, 2012 Volume 29 Number 24
Public Health Action in Genomics
- New report and recommendations from the September 7, 2012 CDC Workshop: New strategies in public health genomics: Actions to save lives now [ PDF 951.81 KB]. Michigan Center for Public Health and Community Genomics. APHA Genomics Forum
- CDC Video: Cascade genetic screening and public health practice: an idea whose time has come
- CDC Genomics Implementation: What public health can do now to save lives
- CDC blog: From genetic counseling in individuals and families to cascade screening in populations: An emerging role for public health practice
- CDC Feature: Twelve health and safety tips for the holidays
- CDC Information: Family health history
- CDC Blog: Family health history and the holidays
- CDC Feature: Gather and Share Your Family Health History
- The importance of family gatherings to your health: Oregonian Dec 4
- Million Hearts Initiative: A family history of heart disease, high blood pressure, or high cholesterol ups your risk for heart attack and stroke. Do you know your family history? Does your doctor? Use this tool to collect, share, and update your family health history
- Could knowing your family health history save your life? Dec 7 blog
- Researchers use powerful genetic techniques to trace Drug-resistant C difficile to source in US and Canadian hospitals, Guardian, Dec 9
- Genomic polish for shoe-leather epidemiology. S. Tong, Nature Rev Micro Dec 3. This month's Genome Watch highlights the advantages of using whole-genome sequencing for infectious-disease surveillance and infection control.
Genomics and Personalized Medicine
- Britain launches genome database to improve patient care, Dec 10
- Up to 100,000 patients with cancer and rare diseases in England are to have their entire genetic code sequenced, BBC News, Dec 10
- BBC News podcast, Dec 10- Sir John Bell: Genetic codes give remarkable insights
- Plans for NHS database of patients' DNA angers privacy campaigners, Dec 8
- Public Health Genomics response to '100,000 genomes' UK announcement (Strategy for UK Life Sciences update) (PDF) from the PHG Foundation, Dec 11
- European Science Foundation Report: Personalized medicine for the European citizen: towards more precise medicine for the diagnosis, treatment and prevention of disease [PDF 3.65 MB}
- NCI Cancer Center News: Genes predict if trastuzumab will work for breast cancer patients- Dec 10
Personal Genome Project
- Personal Genome Project in Canada launches, Dec 9
- PGP-Canada Homepage: Recruiting volunteers who are willing to share their genome sequence and many types of personal information with the research community and the general public
- PGP-USA Homepage: Individuals from the general public have a vital role to play in making personal genomes useful
- Personal Genome Project- A public resource facilitating clinical use of genomes. PNAS 2012; 109
- My genome, unzipped, 10/12/2012 Blog Joe Pickrell
Type 1 Diabetes, Genomics, Prevention and Treatment
- CDC information: What is type 1 and type 2 diabetes?
- CDC information: Diabetes- basics about the diabetes and factors involved in developing type 1 diabetes
- Since 2001, 625 genes have been reported with type 1 Diabetes Mellitus in more than 1000 publications including 31 genomewide association studies. To find out more, visit the HuGENavigator
- Blog: Diabetes stops here from the American Diabetes Association
Von Willebrand Disease
- CDC Information: What should you know about von Willebrand disease?
- When periods are heavy and painful, think genetics: What is von Willebrand disease? ACOG Blog, Nov 29
Nobel Week Dialogue Dec 9
- The genetic revolution and its impact on society, Dec 9, Stockholm
- Do we understand gene-environment interactions? Blog by M Delaney, Dec 9
- How biology entered the information age, Blog by John, Dec 9
- Genetics in agriculture and the environment, Blog by Jim Dec 9
- Genome challenge emerges in sharing DNA benefits across society, Bloomberg News Dec 9
Institute of Medicine, December 11
- IOM emerging infections, microbial threats to health, and the microbiome, December 11
- "Genomics and genetic sequencing have transformed how we respond to emerging infections." --Dr. Anthony Fauci, Director, NIAID
Cognitive and psychological impact of BRCA genetic counseling in before and after definitive surgery breast cancer patients
Christie J, et al. Ann Surg Oncol 2012 Dec;19(13):4003-11
Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips
Shen J, et al. Epigenetics 2012 Dec;8(1)
Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer
Lange CP, et al. PLoS One 2012;7(11):e50266
- RET proto-oncogene genetic screening of families with multiple endocrine neoplasia type 2 optimizes diagnostic and clinical management in China
Qi XP, et al. Thyroid 2012 Dec;22(12):1257-65
- Epigenetics of host-pathogen interactions: the road ahead and the road behind
Gomez-Diaz E, et al. PLoS Pathog 2012 Nov;8(11):e1003007
- Genomics & health video series for students and teachers (NowGEN, UK): 15-minute films that explore how genes can influence people’s health; now and in the future.
- ‘Genes and disease’ –exploring how genomic research is helping scientists to understand a range of illnesses
- ‘Breast cancer in the family’ –one family’s story of breast cancer
- ‘Genomics, decision-making and risk’ –clinicians, researchers and ethicists discuss how genomics has the potential to affect people’s lives
- Bioinformatics: Computational thinking in the era of big data biology
Genomics in Practice
Clinical pharmacogenomics: opportunities and challenges at point of care
Scott SA Clin Pharmacol Ther 2012 Dec
Detecting familial hypercholesterolaemia in general practice
Kirke A, et al. Aust Fam Physician 2012 Dec;41(12):965-8
Effective communication of molecular genetic test results to primary care providers. Scheuner M, et al. Genetics in Medicine Dec 6
- Survey of nursing integration of genomics into nursing practice
Calzone KA, et al. J Nurs Scholarsh 2012 Dec;44(4):428-36
Clinical utility of the X-chromosome array
Zarate YA, et al. Am J Med Genet A 2012 Dec
A better early blood genomic test for autism? PR Newswire, Dec 5
New Reviews and Commentaries on Science & Technology
Gene network illuminates stress, mutation and adaptation responses, ScienceDaily, Dec. 6
Retention and research use of residual newborn screening bloodspots
Botkin JR, et al. Pediatrics 2012 Dec
- Application of genomic technology in prenatal diagnosis.
Dugoff L. N Engl J Med. 2012 Dec 6;367(23):2249-51
- Chromosomal microarray versus karyotyping for prenatal diagnosis
Ronald J. Wapner, Christa Lese Martin, Brynn Levy, et al. New England Journal of Medicine 2012 Dec
- Clinical diagnosis by whole-genome sequencing of a prenatal sample.
Talkowski ME, Ordulu Z, Pillalamarri V, et al. N Engl J Med. 2012 Dec 6;367(23):2226-32.
- Karyotype versus microarray testing for genetic abnormalities after stillbirth.
Reddy UM, Page GP, Saade GR, et al. N Engl J Med. 2012 Dec 6;367(23):2185-93.
- NEJM papers support use of arrays in prenatal Dx as sequencing gains ground, Genome Web, December 6 [by free subscription only]
- Chromosomal microarray versus karyotyping for prenatal diagnosis
Public Health Sciences
- Examining the comorbidity between attention deficit hyperactivity disorder and bipolar I disorder: a meta-analysis of family genetic studies
Faraone SV, et al. Am J Psychiatry 2012 Dec;169(12):1256-66
- Human genetics.genetic influences on disease remain hidden
Kaiser J Science 2012 Nov;338(6110):1016-7
- Tailored second line therapy in asthmatic children with the arginine-16 genotype
Lipworth BJ, et al. Clin Sci (Lond) 2012 Nov
- Why have tobacco control policies stalled? Using genetic moderation to examine policy impacts.
Fletcher JM. PLoS One. 2012;7(12):e50576
Deleterious- and disease-allele prevalence in healthy individuals: insights from current predictions, mutation databases, and population-scale resequencing
Yali Xue, Yuan Chen, Qasim Ayub, et al American Journal of Human Genetics 2012
- Researchers produce a catalogue of the deleterious and disease-causing genetic variants in healthy people, Wellcome Trust Sanger Institut, December 6
- Why doesn't a healthy person's genome sequence reveal more about health and disease? Blog by Mark Wanner, Dec 7
CDC authors are indicated in bold
Whole genome sequence typing to investigate the Apophysomyces outbreak following a tornado in Joplin, Missouri, 2011
Etienne KA, Gillece J, Hilsabeck R, Schupp JM, Colman R, Lockhart SR, Gade L, Thompson EH, Sutton DA, Neblett-Fanfair R, Park BJ, Turabelidze G, Keim P, Brandt ME, Deak E, Engelthaler DM. PLoS One. 2012 ;7(11):e49989.
Deletion of specific immune-modulatory genes from modified vaccinia virus ankara-based HIV vaccines engenders improved immunogenicity in rhesus macaques
Garber DA, O'Mara LA, Gangadhara S, McQuoid M, Zhang X, Zheng R, Gill K, Verma M, Yu T, Johnson B, Li B, Derdeyn CA, Ibegbu C, Altman JD, Hunter E, Feinberg MB. J Virol. 2012 Dec;86(23):12605-15.
Genotyping of rubella virus RNA in sera and dried blood spots collected during routine surveillance and in archival sera
Zheng Q, Abernathy ES, Sun H, Zhu Z, de Filippis A, Akoua-Koffi C, Ahmed H, Morris-Glasgow V, Quist-Therson M, Icenogle JP. J Virol Methods. 2012 Nov 28.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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