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Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science. To receive this update electronically every week sign-up here.
Thursday, August 9, 2012 Volume 29 Number 6
Highlights of the week
Spotlight
New CDC Feature: Genetic Testing for Hereditary Colorectal Cancer
- EGAPP: Informing the effective integration of genomics into health practice—Lynch syndrome
- CDC Podcast: Genetic Testing for Lynch Syndrome in Colorectal Cancer
- My semicolon life: It's not just your cancer, USA Today, August 4
Announcements
- Newborn Screening:
- CDC study: Improving newborn screening follow-up in pediatric practices via the Quality Improvement Innovation Network.
- CDC information on newborn screening
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Cost-effectiveness of expanded newborn screening in Texas
Tiwana SK, et al. Value Health 2012 Jul;15(5):613-21
- Kids and Tobacco
- Health Disparities in Cancer
- Direct to Consumer Genetic Tests:
- CDC Publication: Public awareness and use of direct-to-consumer personal genomic tests from four state population-based surveys, and implications for clinical and public health practice.
Kolor K, Duquette D, Zlot A, et al. Genet Med. 2012 Jul 19. - CDC Blog Post: Think After You Spit: Personal Genomic Tests May Offer a Teachable Moment
- US company seeks approval for personal DNA tests, PHG Foundation, August 1
- CDC Podcast: Personal Genomic Tests
- CDC Publication: Public awareness and use of direct-to-consumer personal genomic tests from four state population-based surveys, and implications for clinical and public health practice.
- Follow Dr. Khoury on Twitter
Topics of the Week
Cancer
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Guidelines for biomarker testing in colorectal carcinoma (CRC): a national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM)
Garcia-Alfonso P, et al. Clin Transl Oncol 2012 Jul -
Predicting breast cancer chemotherapeutic response using a novel tool for microarray data analysis
Cheng J, et al. J Integr Bioinform 2012;9(2):209 -
Prevalence and phenotypes of APC and MUTYH mutations in patients with multiple colorectal adenomas
Grover S, et al. JAMA 2012 Aug;308(5):485-92- APC gene testing for familial adenomatosis polyposis
Roy HK & Khandekar JD JAMA 2012 Aug;308(5):514-5
- APC gene testing for familial adenomatosis polyposis
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Routine TP53 testing for breast cancer under age 30: ready for prime time?
McCuaig JM, et al. Fam Cancer 2012 Aug -
Detection of genomic variations in BRCA1 and BRCA2 genes by long-range PCR and next-generation sequencing.
Hernan I, Borràs E, de Sousa Dias M, et al. J Mol Diagn. 2012 May-Jun;14(3):286-93. - Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes -- a report from the Children's Oncology Group
Blanco JG, Sun CL, Landier W, et al. J Clin Oncol. 2012;30:1415-1421- Using genetic tests to predict anthracycline cardiotoxicity, Medscape Today, August 2
Genomics in Practice
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Privacy protection and public goods: building a genetic database for health research in Newfoundland and Labrador
Kosseim P, et al. J Am Med Inform Assoc 2012 Aug
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Validation of pharmacogenetic algorithms and warfarin dosing table in Egyptian patients
Bazan NS, et al. Int J Clin Pharm 2012 Jul -
Screening the genes, WHO, August 8
Public Health Sciences
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The Association Between Complement Component 2/Complement Factor B Polymorphisms and Age-related Macular Degeneration: A HuGE Review and Meta-Analysis
Thakkinstian A, et al. Am J Epidemiol 2012 Aug
CDC-Authored Genomics Publications
CDC authors are indicated in bold
A hybrid approach for the automated finishing of bacterial genomes
Bashir A, Klammer AA, Robins WP, Chin CS, Webster D, Paxinos E, Hsu D, Ashby M, Wang S, Peluso P, Sebra R, Sorenson J, Bullard J, Yen J, Valdovino M, Mollova E, Luong K, Lin S, Lamay B, Joshi A, Rowe L, Frace M, Tarr CL, Turnsek M, Davis BM, Kasarskis A, Mekalanos JJ, Waldor MK, Schadt EE. Nat Biotechnol. 2012 Jul 1.
Reverse genetics recovery of Lujo virus and role of virus RNA secondary structures in efficient virus growth
Bergeron E, Chakrabarti AK, Bird BH, Dodd KA, McMullan LK, Spiropoulou CF, Nichol ST, Albarino CG. J Virol. 2012 Jul 25.
Identification of diverse Bartonella genotypes among small mammals from Democratic Republic of Congo and Tanzania
Gundi VA, Kosoy MY, Makundi RH, Laudisoit A. Am J Trop Med Hyg. 2012 Aug;87(2):319-26.
Ethnicity interacts with the OPRM1 gene in experimental pain sensitivity
Hastie BA, Riley JL, Kaplan L, Herrera DG, Campbell CM, Virtusio K, Mogil JS, Wallace MR, Fillingim RB. Pain. 2012 Aug;153(8):1610-9.
Frontiers in cancer epidemiology: a challenge to the research community from the Epidemiology and Genomics Research Program at the National Cancer Institute
Khoury MJ, Freedman AN, Gillanders EM, Harvey CE, Kaefer C, Reid BC, Rogers S, Schully SD, Seminara D, Verma M. Cancer Epidemiol Biomarkers Prev. 2012 Jul;21(7):999-1001.
Urinary naphthol metabolites and chromosomal aberrations in 5-year-old children
Orjuela MA, Liu X, Miller RL, Warburton D, Tang D, Jobanputra V, Hoepner L, Suen IH, Diaz-Carreno S, Li Z, Sjodin A, Perera FP. Cancer Epidemiol Biomarkers Prev. 2012 Jul;21(7):1191-202.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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Tweets of the Week