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Genomics & Health Impact Update

Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science.  To receive this update electronically every week sign-up here.

Thursday, April 5, 2012       Volume 28   Number 14

Highlights of the Week:


three generations of woman

New CDC Recommendations Good Laboratory Practices for Biochemical Genetic Testing and Newborn Screening for Inherited Metabolic Disorders


Genomic Pulse

  • More than 4 million babies born in the US every year are screened for inherited metabolic disorders. Good laboratory practices are the foundation for public health programs providing early recognition and timely intervention.

Picks of the Week

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Genomic Tests

For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base and PLoS Currents Evidence on Genomic Tests.

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Family Health History

Parenting Through Genetic Uncertainty: Themes in the Disclosure of Breast Cancer Risk Information to Children
Sharff M, DeMarco T, Mays D, et al. Genetic Testing and Molecular Biomarkers 2011 Nov 15

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Practice and Programs

Just how feasible is pharmacogenetic testing in the primary healthcare setting?
Swen JJ & Guchelaar HJ Pharmacogenomics 2012 Apr;13(5):507-9

Next-generation community genetics for low- and middle-income countries
Kingsmore SF, et al. Genome Med 2012 Mar;4(3):25

On the future of genetic risk assessment
Ropers HH J Community Genet 2012 Apr

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Policy and Legislation

Presidential bioethics panel seeks input on sequencing-related issues, Genome Web, March 30 [by free subscription only]

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Public Health Science

Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias.
Clarke R, Bennett DA, Parish S, et al. PLoS Med. 2012 Feb;9(2):e1001177.

Is homocysteine a CHD risk factor? The genetic view, Medscape, April 2 [by free subscription only]

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Barretina J, Caponigro G, Stransky N, et al. 2012 Nature 483, 603-307 Mar 29

Huge cancer knowledge resource made public, Medical News Today, March 30

Systematic identification of genomic markers of drug sensitivity in cancer cells
Garnett M, Edelman E, Heidorn S, et al. Nature 2012; 483, 570-575 Mar 28

The path to personalised cancer treatment, Wellcome Trust Sanger, March 28

170 human genome epidemiology articles have recently been added, please visit the HuGE Literature Finder in the HuGE Navigator.

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CDC-Authored Genomics Publications

CDC authors are indicated in bold

Analysis of influenza viruses from patients clinically suspected of infection with an oseltamivir resistant virus during the 2009 pandemic in the United States
Nguyen HT, Trujillo AA, Sheu TG, Levine M, Mishin VP, Shaw M, Ades EW, Klimov AI, Fry AM, Gubareva LV. Antiviral Res. 2012 Mar;93(3):381-6.

Bartonella bacteria in nature: where does population variability end and a species start?
Kosoy M, Hayman DT, Chan KS. Infect Genet Evol. 2012 Mar 23.

Characterization of multi-drug resistant Salmonella enterica serovar Heidelberg from a ground turkey-associated outbreak in the United States, 2011
Folster JP, Pecic G, Rickert R, Taylor J, Zhao S, Fedorka-Cray PL, Whichard J, McDermott P. Antimicrob Agents Chemother. 2012 Mar 26.

Epidemic history of hepatitis C virus infection in two remote communities in Nigeria, West Africa
Forbi JC, Purdy MA, Campo DS, Vaughan G, Dimitrova ZE, Ganova-Raeva LM, Xia GL, Khudyakov YE. J Gen Virol. 2012 Mar 28.

Experiences from the shiga toxin-producing escherichia coli O104:H4 outbreak in Germany and research needs in the field, Berlin, 28-29 November 2011
Stark K, Bauerfeind R, Bernard H, Eckmanns T, Ethelberg S, Flieger A, Giesecke J, Greiner M, Karch H, Krause G, Mielke M, O'Brien SJ, Pulz M, Scheutz F, Schielke A, Stahl RA, Takkinen J, Tarr PI, Tauxe RV, Werber D. Eurosurveillance. 2012 ;17(7).

Molecular genetic testing for fragile X syndrome: laboratory performance on the College of American Pathologists proficiency surveys (2001-2009)
Weck KE, Zehnbauer B, Datto M, Schrijver I. Genet Med. 2012 Mar;14(3):306-12.

Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival
Cilloniz C, Pantin-Jackwood MJ, Ni C, Carter VS, Korth MJ, Swayne DE, Tumpey TM, Katze MG. J Virol. 2012 Mar;86(5):2437-46.

Pooling nasopharyngeal/throat swab specimens to increase testing capacity for influenza viruses by PCR
Van TT, Miller J, Warshauer DM, Reisdorf E, Jernigan D, Humes R, Shult PA. J Clin Microbiol. 2012 Mar;50(3):891-6.

View previous CDC-authored publications

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Let's Go Surfing

Getting a head start: the importance of personal genetics education in high schools
Kung JT & Gelbart ME Yale J Biol Med 2012 Mar;85(1):87-92

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Events and Training

From Population Health to Personal Health
April 17-20 ~ Rome, Italy

Pharmacology & Pharmcogenomics for Nurses
April 27 ~ Fayetteville, NC

Ovarian Cancer: Prevention, Detection and Treatment of the Disease and Its Recurrence
May 10-11 ~ Pittsburgh, PA

Access other events

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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.


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