Genomics & Health Impact Update
The Office of Public Health Genomics (OPHG) provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation. We hope the update is informative to practitioners, policy makers, consumers, and researchers. Please send your comments to: firstname.lastname@example.org.
Thursday, September 22, 2011 Volume 27 Number 12
Million Hearts is a national initiative to prevent 1 million heart attacks and strokes over the next five years CDC Feature: Million Hearts: Preventing Heart Attacks and Strokes
- Heart disease and family history
- Learn more about the role of family history and how to collect it
- CDC podcast on familial hypercholesterolemia
- EGAPP recommendation on genomic profiling in risk assessment for heart disease
- Heart to Heart: Inherited cardiovascular conditions services
- CDC Feature: Learn more about Sickle Cell Disease
Find out more about genomics and heart disease:
Evolving Research and Stakeholder Perspectives on Pharmacogenomics
Amber L. Beitelshees, David L. Veenstra; JAMA. 2011;306(11):1252-1253
Can Factor V Leiden and prothrombin G20210A testing in women with recurrent pregnancy loss result in improved pregnancy outcomes? Results from a targeted evidence-based review
Bradley LA, et al. Genet Med 2011 Sep
Clinical utility gene card for: Phenylketonuria
Zschocke J, et al. Eur J Hum Genet 2011 Sep
Data-Based Considerations for Electronic Family Health History Applications
Peace J, et al. Comput Inform Nurs 2011 Sep
Family history and herpes zoster risk in the era of shingles vaccination
Hernandez PO, et al. J Clin Virol 2011 Sep
New computerized family history aimed at screening for preterm birth and other inherited diseases, March of Dimes, September 21
Expanded newborn screening: articulating the ontology of diseases with bridging work in the clinic
Timmermans S & Buchbinder M Sociol Health Illn 2011 Sep
Warfarin pharmacogenetics meets clinical use
Schwab M & Schaeffeler E Blood 2011 Sep;118(11):2938-9
International approaches to rare diseases, PHG Foundation, September 19
Pharmacogenomics: a new clinical or regulatory paradigm? European experiences of pharmacogenomics in drug regulation and regulatory initiatives
Prasad K & Breckenridge A Drug Discov Today 2011 Sep
Cancer gene patents upheld by court -- at least for now, Medscape, September 16
Pharmacogenomic Prediction of Anthracycline-Induced Cardiotoxicity in Children.
Visscher H, Ross CJ, Rassekh SR, et al. J Clin Oncol. 2011 Sep 9.
Common genetic variants associated with development of high-risk neuroblastoma, Medical News Today, September 20
Genome-wide association study identifies five new schizophrenia loci.
Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium, et al. Nat Genet. 2011 Sep 18.
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
Psychiatric GWAS Consortium Bipolar Disorder Working Group, et al. Nat Genet. 2011 Sep 18.
Common genetic variations linked to both schizophrenia and bipolar risk, Science Daily, September 19
Gene Therapy for Leber Congenital Amaurosis Caused by RPE65 Mutations: Safety and Efficacy in 15 Children and Adults Followed Up to 3 Years.
Jacobson SG, Cideciyan AV, Ratnakaram R, et al. Arch Ophthalmol. 2011 Sep 12.
Gene therapy may restore vision in LCA, Medscape, September 15
Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence.
Dewey FE, Chen R, Cordero SP, Ormond KE, et al. .PLoS Genet 7(9): e1002280
Family receives novel genome analysis of their health risks, Stanford News, September 15
CDC authors are indicated in bold
Characterization of Helicobacter pylori cagA and vacA genotypes among Alaskans and their correlation with clinical disease
Miernyk K, Morris J, Bruden D, McMahon B, Hurlburt D, Sacco F, Parkinson A, Hennessy T, Bruce M. J Clin Microbiol. 2011 Sep;49(9):3114-21.
Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome
Smith AK, Fang H, Whistler T, Unger ER, Rajeevan MS. Neuropsychobiology. 2011 ;64(4):183-94.
Identification of Leishmania spp. by molecular amplification and DNA sequencing analysis of a fragment of rRNA internal transcribed spacer 2
de Almeida ME, Steurer FJ, Koru O, Herwaldt BL, Pieniazek NJ, da Silva AJ. J Clin Microbiol. 2011 Sep;49(9):3143-9.
Multi-locus variable number tandem repeat analysis for investigation of the genetic association of Clostridium difficile isolates from food, food animals and humans
Marsh JW, Tulenko MM, Shutt KA, Thompson AD, Weese JS, Songer JG, Limbago BM, Harrison LH. Anaerobe. 2011 Aug;17(4):156-60.
Conference Scene: Four decades of modern pharmacogenomics: from promise to clinical utility
Groenen PM. Pharmacogenomics 2011 Sep;12(9):1249-52
International Cancer Genome Consortium Data Portal--a one-stop shop for cancer genomics data
Zhang J, et al. Database (Oxford) 2011;2011:bar026
Poll on interest in personal genome information, PHG Foundation, September 19
Will we all be tweaking our own genetic code? BBC News, September 18
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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