 For information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base |
 For information on genomic applications in cancer care and prevention, please visit the CancerGEM Knowledge Base |
Genomics & Health Impact Update
The Office of Public Health Genomics (OPHG) provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation. We hope the update is informative to practitioners, policy makers, consumers, and researchers. Please send your comments to: genetics@cdc.gov.
Thursday, September 15, 2011 Volume 27 Number 11
Spotlight
Million Hearts is a national initiative to prevent 1 million heart attacks and strokes over the next five years
Find out more about genomics and heart disease:
- CDC Feature: Million Hearts: Preventing Heart Attacks and Strokes
- Heart disease and family history
- Learn more about the role of family history and how to collect it
- CDC podcast on familial hypercholesterolemia
- EGAPP recommendation on genomic profiling in risk assessment for heart disease
Announcements
- CDC Feature: Learn more about Sickle Cell Disease
- Blog post: Think (Again) Before You Spit: Readers Weigh In
Topics
Genomic Tests
Cost-effectiveness of KRAS testing in metastatic colorectal cancer patients in the United States and Germany
Vijayaraghavan A, et al. Int J Cancer 2011 Aug
Clinical utility gene card for: Mayer-Rokitansky-Kuster-Hauser syndrome
Morcel K, et al. Eur J Hum Genet 2011 Sep
Should pharmacogenetics be incorporated in major depression treatment? Economic evaluation in high- and middle-income European countries
Olgiati P, et al. Prog Neuropsychopharmacol Biol Psychiatry 2011 Sep
The clinical effectiveness and cost-effectiveness of genotyping for CYP2D6 for the management of women with breast cancer treated with tamoxifen: a systematic review
Fleeman N, et al. Health Technol Assess 2011 Sep;15(33):1-102
For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base and PLoS Currents Evidence on Genomic Tests.
Practice and Programs
A pre-visit tailored website enhances counselees' realistic expectations and knowledge and fulfils information needs for breast cancer genetic counselling
Albada A, et al. Fam Cancer 2011 Sep
Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 Genotypes and Warfarin Dosing
Johnson JA, et al. Clin Pharmacol Ther 2011 Sep
Newborn Screening for Hemoglobin Disorders
Hoppe CC Hemoglobin 2011 Sep
Genetic screening by nurses reduces specialist referrals, Bio News, September 12
Colorectal cancer: New tools for making decisions about treatment, Oncology Nurse Advisor, September 9
Policy and Legislation
Health Matters: FDA approves new drug for lung cancer, NBC, September 13
Public Health Science
Evaluation of newborn screening bloodspot-based genetic testing as second tier screen for bedside newborn hearing screening
Schimmenti LA, et al. Genet Med 2011 Sep
Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1
Scott A LeMaire, Merry-Lynn N McDonald, Dong-chuan Guo, et al. Nature Genetics 2011, Sept. 11
Genetic testing for aortic aneurysms could spur early treatment and save lives, ABC News, September 14
Thrombomodulin Gene Variants Are Associated With Increased Mortality After Coronary Artery Bypass Surgery in Replicated Analyses.
R. L. Lobato, W. D. White, J. P. Mathew, et al. Circulation, 2011; 124 (11_suppl_1): S143
Genetic variant linked with mortality following coronary bypass surgery, Medical News Today, September 14
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma
Ferreira M.A.R. et al. Lancet 2011;378(9795):1006
New asthma risk genes suggest link with other diseases, PHG Foundation, September 13
Earlier age of onset of BRCA mutation-related cancers in subsequent generations
Litton J, Ready K, Chen H, et al. Cancer 2011 Sep 12
Breast cancer patients with BRCA gene diagnosed almost 8 years earlier than generation before, EurekAlert, September 12
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
The International Consortium for Blood Pressure Genome-Wide Association Studies. Nature 2011 Sep 11
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
Wain LV, Verwoert GC, O'Reilly PF, et al. Nat Genet. 2011 Sep 11.
International genome consortium discovers new genes that control blood pressure, NIH News, September 12
A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry.
Duncan LE, Keller MC. Am J Psychiatry. 2011 Sep 2.
Improvements needed to enhance accuracy in gene-by-environment interaction studies, Medical News Today, September 11
Exciting advances in cardiovascular genomics, Medscape, September 11 [by free subscription only]
160 human genome epidemiology articles have recently been added, please visit the HuGE Literature Finder in the HuGE Navigator.
CDC-Authored Genomics Publications
CDC authors are indicated in bold
Identifying host genetic risk factors in the context of public health surveillance for invasive pneumococcal disease
Lingappa JR, Dumitrescu L, Zimmer SM, Lynfield R, McNicholl JM, Messonnier NE, Whitney CG, Crawford DC.
PLoS One. 2011 ;6(8):e23413.
IRon Overload screeNing tool (IRON): development of a tool to guide screening in primary care
Mainous AG, Diaz VA, Everett CJ, Knoll ME, Hulihan MM, Grant AM, McLaren CE, McLaren GD. Am J Hematol. 2011 Sep;86(9):733-7.
View previous CDC-authored publications
Let's Go Surfing
Safety through genomics, Genome Web, September [by free subscription only]
Take the 'Talking Glossary of Genetic terms' mobile app with you, NHGRI, September 12
Personalized Medicine Day in Georgia, Emory Health Now Blog, September 9
Events and Training
Next-Gen 101: A How-To for Whole-Exome Sequencing Research
24th Annual International Society of Nurses in Genetics
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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