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Genomics & Health Impact Update

The Office of Public Health Genomics (OPHG) provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation. We hope the update is informative  to practitioners, policy makers, consumers, and researchers. Please send your comments to:

Thursday, September 1, 2011       Volume 27   Number 9


woman looking at test tube and thinking

New blog "Think before you spit: do personal genomic tests improve health?"




Genomic Tests

Clinical utility gene card for: Cystinuria
Eggermann T, et al. Eur J Hum Genet 2011 Aug

Clinical utility gene card for: Mucopolysaccharidosis type II
Beck M, et al. Eur J Hum Genet 2011 Aug

Clinical utility gene card for: multiple endocrine neoplasia type 2
Raue F, et al. Eur J Hum Genet 2011 Aug

For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base and PLoS Currents Evidence on Genomic Tests.

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Family Health History

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Practice and Programs

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Policy and Legislation

FDA approves Pfizer drug to treat lung cancer in patients with genetic mutation, The Washington Post, August 26

Despite gene patent victory, Myriad Genetics faces challenges, The New York Times, August 25

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Data and Statistics

Temporal Dynamics of Host Molecular Responses Differentiate Symptomatic and Asymptomatic Influenza A Infection
Yongsheng Huang, Aimee K. Zaas, Arvind Rao, et al. PLoS Genetics 2011 Aug

Risk of Breast Cancer in Women With a CHEK2 Mutation With and Without a Family History of Breast Cancer
Cybulski D, Wokołorczyk D, Jakubowska A, et al.  J Clin Oncol. 2011 Aug 29.

Germline BAP1 mutations predispose to malignant mesothelioma.
Testa JR, Cheung M, Pei J, et al. Nat Genet. 2011 Aug 28.

Long-term persistence of a polyclonal T cell repertoire after gene therapy for x-linked severe combined immunodeficiency.
Gaspar HB, Cooray S, Gilmour KC, et al. Sci Transl Med. 2011 Aug 24;3(97):97ra79.

131 human genome epidemiology articles have recently been added, please visit the HuGE Literature Finder in the HuGE Navigator.

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CDC-Authored Genomics Publications

CDC authors are indicated in bold

Common ancestry and novel genetic traits of Francisella novicida-like isolates from North America and Australia as revealed by comparative genomic analyses
Siddaramappa S, Challacombe JF, Petersen JM, Pillai S, Hogg G, Kuske CR. Appl Environ Microbiol. 2011 Aug;77(15):5110-22.

Cost-effectiveness analysis of diagnostic options for pneumocystis pneumonia (PCP)
Harris JR, Marston BJ, Sangrujee N, Duplessis D, Park B. PLoS One. 2011 ;6(8):e23158.

Demographic but not geographic insularity in HIV transmission among young black men who have sex with men, Mississippi, USA
Oster AM, Pieniazek D, Zhang X, Switzer WM, Ziebell RA, Mena LA, Wei X, Johnson KL, Singh SK, Thomas PE, Elmore KA, Heffelfinger JD. AIDS. 2011 Aug 23.

Detection of the first G6P[14] human rotavirus strain from a child with diarrhea in Egypt
El Sherif M, Esona MD, Wang Y, Gentsch JR, Jiang B, Glass RI, Baker SA, Klena JD. Infect Genet Evol. 2011 Aug;11(6):1436-42.

Emergence of a new pathogenic Ehrlichia species, Wisconsin and Minnesota, 2009
Pritt BS, Sloan LM, Johnson DK, Munderloh UG, Paskewitz SM, McElroy KM, McFadden JD, Binnicker MJ, Neitzel DF, Liu G, Nicholson WL, Nelson CM, Franson JJ, Martin SA, Cunningham SA, Steward CR, Bogumill K, Bjorgaard ME, Davis JP, McQuiston JH, Warshauer DM, Wilhelm MP, Patel R, Trivedi VA, Eremeeva ME. N Engl J Med. 2011 Aug 4;365(5):422-9.

Genotypic distribution of hepatitis B Virus (HBV) among acute cases of HBV infection, selected US counties, 1999-2005
Teshale EH, Ramachandran S, Xia GL, Roberts H, Groeger J, Barry V, Hu DJ, Holmberg SD, Holtzman D, Ward JW, Teo CG, Khudyakov Y. Clin Infect Dis. 2011 Aug 22.

Mycobacterium shinjukuense sp. nov., a slowly growing, non-chromogenic species isolated from human clinical specimens
Saito H, Iwamoto T, Ohkusu K, Otsuka Y, Akiyama Y, Sato S, Taguchi O, Sueyasu Y, Kawabe Y, Fujimoto H, Ezaki T, Butler R. Int J Syst Evol Microbiol. 2011 Aug;61(Pt 8):1927-32.

View previous CDC-authored publications

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Let's Go Surfing

Genetic Risk Prediction in Complex Disease
Jostins L & Barrett JC Hum Mol Genet 2011 Aug

The new generation of microbe hunters, The New York Times, August 29

Britain to launch personalized medicine project, Nature News, August 26

NIA plans to fund innovative genotype-phenotype studies of aging, Genome Web, August 26 [by free subscription only]

Sequencing kids' genomes to learn how cancer grows, Fast Company, August 26

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Events and Training

UK Pharmacogenetics and Stratified Medicine Network

9th Malaysia Genetic Congress

Harmonizing Genetic Testing Across Europe

Access other events

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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.


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