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Genomics & Health Impact Update

Published by the Office of Public Health Genomics (OPHG), the Update offers links to genomics news and publications relevant to public health. The Update highlights family health history and genomic tests, along with relevant data, policy, and legislation. Please send your comments to:

Thursday, October 20, 2011       Volume 27   Number 16


father hugging his wife and daughter

Blog post "A Million Hearts, A Thousand Genes, and Your Family History"



Genomic Tests

Clinical utility gene card for: Central core disease
Lillis S, et al. Eur J Hum Genet 2011 Oct

DNA sequencing of maternal plasma to detect Down syndrome: An international clinical validation study
Palomaki G, Kloza E, Lambert-Messerlian G, et al. Genet Med. 2011 Oct 14.

A less risky Down Syndrome test is developed, The New York Times, October 17

For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base and PLoS Currents Evidence on Genomic Tests.

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Family Health History

Role of Family History for Alzheimer Biomarker Abnormalities in the Adult Children Study
Xiong C, Roe CM, Buckles V, et al. Arch Neurol. 2011 Oct;68(10):1313-9.

Family history of Alzheimer's linked to preclinical markers, Medscape, October 17 [by free subscription only]

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Practice and Programs

CDC funds states' breast cancer genomics initiatives, Genome Web, October 13 [by free subscription only]

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Policy and Legislation

ACLU, PUBPAT to ask supreme court to take up gene patenting case, Genome Web, October 13 [by free subscription only]

Should researchers reveal genetic findings? PHG Foundation, October 13

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Public Health Science

Defining variations in survival of BRCA1 and BRCA2 mutation carriers
Grann VR & Parsons RE JAMA 2011 Oct;306(14):1597-8

APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy
Kopp JB, Nelson GW, Sampath K, et al. J Am Soc Nephrol. 2011 Oct 13

Population-based Risk Assessment of APOL1 on Renal Disease.
Friedman DJ, Kozlitina J, Genovese G, et al. J Am Soc Nephrol. 2011 Oct 13

Genetic Variation in APOL1 Associates with Younger Age at Hemodialysis Initiation.
Kanji Z, Powe CE, Wenger JB, et al. J Am Soc Nephrol. 2011 Oct 13.

APOL1 Localization in Normal Kidney and Nondiabetic Kidney Disease.
Madhavan SM, O'Toole JF, Konieczkowski M, et al. J Am Soc Nephrol. 2011 Oct 13.

164 human genome epidemiology articles have recently been added, please visit the HuGE Literature Finder in the HuGE Navigator.

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CDC-Authored Genomics Publications

CDC authors are indicated in bold

The ACE I/D polymorphism in US adults: limited evidence of association with hypertension-related traits and sex-specific effects by race/ethnicity
Ned RM, Yesupriya A, Imperatore G, Smelser DT, Moonesinghe R, Chang MH, Dowling NF. Am J Hypertens. 2011 Oct 13.

Ancient ancestry of KFDV and AHFV revealed by complete genome analyses of viruses isolated from ticks and mammalian hosts
Dodd KA, Bird BH, Khristova ML, Albarino CG, Carroll SA, Comer JA, Erickson BR, Rollin PE, Nichol ST. PLoS Negl Trop Dis. 2011 Oct;5(10):e1352.

Development of multiplexed species specific polymerase chain reaction assays for identification of the Culex (Melanoconion) species (Diptera: Culicidae) of the southeastern United States based on rDNA
Williams MR, Savage HM. J Med Entomol. 2011 Sep;48(5):961-6.

Host genetic risk factors for West Nile virus infection and disease progression
Bigham AW, Buckingham KJ, Husain S, Emond MJ, Bofferding KM, Gildersleeve H, Rutherford A, Astakhova NM, Perelygin AA, Busch MP, Murray KO, Sejvar JJ, Green S, Kriesel J, Brinton MA, Bamshad M. PLoS One. 2011 ;6(9):e24745.

Human infection with novel G3P[25] rotavirus strain in Taiwan
Wu FT, Banyai K, Huang JC, Wu HS, Chang FY, Hsiung CA, Huang YC, Lin JS, Hwang KP, Jiang B, Gentsch JR. Clin Microbiol Infect. 2011 Oct;17(10):1570-1573.

View previous CDC-authored publications

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Let's Go Surfing

Outbreak detectives embrace the genome era
Kupferschmidt K Science 2011 Sep;333(6051):1818-9

Genomic medicine has failed the poor, Nature News, October 19

Scripps launches sequencing study of mysterious diseases, Genome Web, October 18 [by free subscription only]

EMR-based algorithm portable, productive, and cost effective, Medscape, October 17 [by free subscription only]

Scientists map 115-year-old woman's genome to study longevity, Medical News Today, October 17

BGI to sequence thousands of genomes for autism speaks, Genome Web, October 13 [by free subscription only]

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Events and Training

Phenotype and the flexible genome: the role of epigenetic processes in development and human disease

The 6th International Conference on Genomics

Functional Genomics and Systems Biology 2011

Access other events

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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.


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