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Genomics & Health Impact Update

The Office of Public Health Genomics (OPHG) provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation. We hope the update is informative  to practitioners, policy makers, consumers, and researchers. Please send your comments to: genetics@cdc.gov.


Thursday, October 6, 2011       Volume 27   Number 14


Spotlight

Three generations of women

October is National
Breast Cancer
Awareness Month

 






Announcements




Topics


Genomic Tests

For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base and PLoS Currents Evidence on Genomic Tests.

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Family Health History

Breast and ovarian cancer: Y do we forget about dad?
McCuaig JM, Greenwood C, Shuman C, et al.  Lancet Oncol. 2010 Dec;11(12):1115-7.

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Practice and Programs

Universal newborn screening for congenital heart disease in US, PHG Foundation, October 5

Primary Care: You DO need to know about genomics -- here's why, Medscape, October 4 [by free subscription only]

Testing for breast cancer mutations, not for everyone, Medical News Today, October 4

Breast cancer: Treatment is no longer one-size-fits-all, The Los Angeles Times, October 1

Kids in America- Newborn Screening for Cystic Fibrosis, Medscape, September 29 [by free subscription only]

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Policy and Legislation

CCMG Statement on Direct-to-Consumer Genetic Testing
Nelson TN, et al. Clin Genet 2011 Sep

Genomics, health care, and society
Hudson KL N Engl J Med 2011 Sep;365(11):1033-41

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Public Health Science

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
Renton AE, Majounie E, Waite A, et al. Neuron 2011 Sep 21.

Clan genomics and the complex architecture of human disease.
Lupski JR, Belmont JW, Boerwinkle E, et al. Cell 2011 Sep 30;147(1):32-43.

88 human genome epidemiology articles have recently been added, please visit the HuGE Literature Finder in the HuGE Navigator.

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CDC-Authored Genomics Publications


CDC authors are indicated in bold

Development of DENVax: A chimeric dengue-2 PDK-53-based tetravalent vaccine for protection against dengue fever
Osorio JE, Huang CY, Kinney RM, Stinchcomb DT. Vaccine. 2011 Sep 23;29(42):7251-60.

DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomized clinical trials.
Julie E Ledgerwood, Chih-Jen Wei, Zonghui Hu, Ingelise J Gordon, Mary E Enama, Cynthia S Hendel, Patrick M McTamney, Melissa B Pearce, Hadi M Yassine, Jeffrey C Boyington, Robert Bailer, Terrence M Tumpey, Richard A Koup, John R Mascola, Gary J Nabel, Barney S Graham, the VRC 306 Study Team.  The Lancet Infectious Diseases 2011 Oct 4

Evaluation of intra-host variants of the entire hepatitis B virus genome
Ramachandran S, Zhai X, Thai H, Campo DS, Xia G, Ganova-Raeva LM, Drobeniuc J, Khudyakov YE. PLoS One. 2011 ;6(9):e25232.

Joint associations between genetic variants and reproductive factors in glioma risk among women
Wang SS, Hartge P, Yeager M, Carreon T, Ruder AM, Linet M, Inskip PD, Black A, Hsing AW, Alavanja M, Beane-Freeman L, Safaiean M, Chanock SJ, Rajaraman P. Am J Epidemiol. 2011 Sep 13.

Down syndrome: national conference on patient registries, research databases, and biobanks
Oster-Granite ML, Parisi MA, Abbeduto L, Berlin DS, Bodine C, Bynum D, Capone G, Collier E, Hall D, Kaeser L, Kaufmann P, Krischer J, Livingston M, McCabe LL, Pace J, Pfenninger K, Rasmussen SA, Reeves RH, Rubinstein Y, Sherman S, Terry SF, Siewhitten M, Williams S, McCabe ER, Maddox YT. Mol Genet Metab. 2011 Sep-Oct;104(1-2):13-22.

Genome sequences for five strains of the emerging pathogen Haemophilus haemolyticus
Jordan IK, Conley AB, Antonov IV, Arthur RA, Cook ED, Cooper GP, Jones BL, Knipe KM, Lee KJ, Liu X, Mitchell GJ, Pande PR, Petit RA, Qin S, Rajan VN, Sarda S, Sebastian A, Tang S, Thapliyal R, Varghese NJ, Ye T, Katz LS, Wang X, Rowe L, Frace M, Mayer LW. J Bacteriol. 2011 Oct;193(20):5879-80.

Next generation dengue vaccines: a review of candidates in preclinical development
Schmitz J, Roehrig J, Barrett A, Hombach J. Vaccine. 2011 Sep 23;29(42):7276-84.

A novel multi-target real-time PCR assay for the rapid diagnosis of Bordetella species in clinical specimens
Tatti KM, Sparks KN, Boney KO, Tondella ML. J Clin Microbiol. 2011 Sep 21.

South American Plasmodium falciparum after the malaria eradication era: clonal population expansion and survival of the fittest hybrids
Griffing SM, Mixson-Hayden T, Sridaran S, Alam MT, McCollum AM, Cabezas C, Marquino Quezada W, Barnwell JW, Macedo De Oliveira A, Lucas C, Arrospide N, Escalante AA, Bacon DJ, Udhayakumar V. PLoS One. 2011 ;6(9):e23486.

Structural gene (prME) chimeras of St. Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes
Maharaj PD, Anishchenko M, Langevin SA, Fang Y, Reisen WK, Brault AC. J Gen Virol. 2011 Sep 21.

View previous CDC-authored publications

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Let's Go Surfing


 

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Events and Training


15th Annual Meeting Collaborative Group of the Americas, on Inherited Colorectal Cancer (CGA-ICC)

3rd Course 'Prenatal Genetic Diagnosis'

5th Congress of the International Society of Nutrigenetics/Nutrigenomics (ISNN)

Access other events

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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.

 

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