Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update offers links to genomics news and publications relevant to public health. The Update highlights family health history and genomic tests, along with relevant data, policy, and legislation. Please send your comments to: email@example.com.
Thursday, November 17, 2011 Volume 27 Number 20
CDC Expert Commentary on Medscape: "Pharmacogenomics and Your Practice"
- New publication: Clinical utility of family history for cancer screening and referral in primary care: A report from the Family Healthware Impact Trial. Rubinstein WS, Acheson LS, Oʼneill SM, et al. Genet Med. 2011 Nov;13(11):956-965.
- Blog post "Can We Have Our Genome And Eat It Too? Deploying The Whole Genome Sequence In Medicine And Public Health, One Base Pair At A Time"
- November is Diabetes Awareness Month:
Clinical utility gene card for: Adrenoleukodystrophy
Krasemann E, et al. Eur J Hum Genet 2011 Nov
Dosing Clopidogrel Based on CYP2C19 Genotype and the Effect on Platelet Reactivity in Patients With Stable Cardiovascular Disease
Mega J, Hochholzer W, Frelinger A, et al. JAMA 2011 Nov 16
Genetic tests can predict who needs higher doses of Plavix, USA Today, November 16
Raising Clopidogrel dosage for patients with genetic variation improves drug response, Medical News Today, November 16
Blood-based genomic test better than imaging test for ruling out obstructive coronary artery disease, EurekAlert, November 15
Clinical utility of family history for cancer screening and referral in primary care: A report from the Family Healthware Impact Trial
Rubinstein WS, et al. Genet Med 2011 Nov;13(11):956-65
FHH in Health Centers, Genetic Alliance
Family History Matters! [PDF 258.98 KB] University of Washington, November 2011
Young women with family history of breast cancer and their risk factors for benign breast disease
Berkey C, Tamimi R, Rosner B, et al. Cancer 2011 Nov 14
Family history, alcohol intake, and benign breast disease, Medscape, November 14
Screenings key to identifying genetic cancer risk, MDNews, November 14
Factors accounting for a missed diagnosis of cystic fibrosis after newborn screening
Rock MJ, et al. Pediatr Pulmonol 2011 Dec;46(12):1166-74
Genetics for the General Internist
Laukaitis CM Am J Med 2011 Nov
Health-care providers' views on pursuing reproductive benefit through newborn screening: the case of sickle cell disorders
Bombard Y, et al. Eur J Hum Genet 2011 Nov
Newborn Screening for Severe Combined Immunodeficiency; The Wisconsin Experience (2008-2011)
Verbsky JW, et al. J Clin Immunol 2011 Nov
Outcomes of Integrating Genetics in Management of Patients With Retinoblastoma
Dhar S, Chintagumpala M, Noll C, et al. Arch Ophthalmol. 2011;129(11):1428-1434
Team approach may be helpful for integrating genetic testing in management of retinoblastoma, EurekAlert, November 14
Teen athletes often not screened for heart risks, study finds, MSNBC, November 13
Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice
Sequist L, Heist R, Shaw A, et al. Ann Oncol (2011) Nov 9
SNaPshot: Screening for Many Mutations at Once, Medscape Today, November 11 [by free subscription only]
Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents: Summary Report[PDF 631.31 KB]
Kavey R, Simons-Morton D, de Jesus J; Pediatrics 2011
Doctors: Test all kids for cholesterol by age 11, MSNBC, November 11
Can pharmacogenomics improve malaria drug policy?
Roederer MW, et al. Bull World Health Organ 2011 Nov;89(11):838-45
Pharmacogenetic risk for adverse reactions to irinotecan in the major ethnic populations of singapore: regulatory evaluation by the health sciences authority.
Sung C, Lee PL, Tan LL, et al. Drug Saf. 2011 Dec 1;34(12):1167-75.
ADHDgene: a genetic database for attention deficit hyperactivity disorder
Zhang L, et al. Nucleic Acids Res 2011 Nov
Self-reported mammography use following BRCA1/2 genetic testing may be overestimated
Larouche G, et al. Fam Cancer 2011 Nov
Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition
Kogan A, Saslow L, Impett E, et al. PNAS 2011 Nov 4
Is empathy in our genes? CNN Health, November 15
Abundant pleiotropy in human complex diseases and traits.
Sivakumaran S, Agakov F, Theodoratou E, et al. Am J Hum Genet. 2011 Nov 11;89(5):607-18.
Genes 'linked to multiple diseases', BBC News, November 11
Breast Cancer Risk for Noncarriers of Family-Specific BRCA1 and BRCA2 Mutations: Findings From the Breast Cancer Family Registry.
Kurian AW, Gong GD, John EM, et al. J Clin Oncol. 2011 Nov 7.
Women without BRCA mutations have normal cancer risk, PHG Foundation, November 11
Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non–Small Cell Lung Cancer
Juergens R, Wrangle J, Vendetti F, et al. Cancer Discovery 2011 Nov 9
New epigenetic combo shows some dramatic responses in NSCLC, Medscape Today, November 10 [by free subscription only]
CDC authors are indicated in bold
Global population structure of Aspergillus terreus inferred by ISSR typing reveals geographical subclustering
Neal CO, Richardson AO, Hurst SF, Tortorano AM, Viviani MA, Stevens DA, Balajee SA. BMC Microbiol. 2011 ;11:203.
Informational privacy, public health, and state laws
O'Connor J, Matthews G. Am J Public Health. 2011 Oct;101(10):1845-50.
Serology as an adjunct to polymerase chain reaction assays for surveillance of acute respiratory virus infections
Sawatwong P, Chittaganpitch M, Hall H, Peruski LF, Xu X, Baggett HC, Fry AM, Erdman DD, Olsen SJ. Clin Infect Dis. 2011 Nov 4.
Streptococcus pneumoniae serotype 9A isolates contain diverse mutations to wcjE that result in variable expression of serotype 9V-specific epitope
Calix JJ, Oliver MB, Sherwood LK, Beall BW, Hollingshead SK, Nahm MH. J Infect Dis. 2011 Nov;204(10):1585-95.
Using microbial genome data for global public health, PHG Foundation, November 15
MicroRNAs in the Pathogenesis of Cancer.
Lovat F, Valeri N, Croce CM. Semin Oncol. 2011 Dec;38(6):724-33.
Blood test finds lung cancer 2 years before scans, Health News Digest, November 14
Medical data explosion requires urgent system changes, PHG Foundation, November 14
Noninvasive prenatal diagnosis of a fetal microdeletion syndrome.
Peters D, Chu T, Yatsenko SA, et al. N Engl J Med. 2011 Nov 10;365(19):1847-8.
Non-invasive prenatal diagnosis of a microdeletion, PHG Foundation, November 14
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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