Genomics & Health Impact Update

Genotype-based dosing algorithms for warfarin therapy: data review and recommendations
Johnson EG, et al. Mol Diagn Ther 2011 Oct;15(5):255-64

Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice
Sequist L, Heist R, Shaw A, et al. Ann Oncol (2011) Nov 9

Researchers find way to screen for broad range of cancer-causing genetic changes, EurekAlert, November 8

High False-Negative Rate of HER2 Quantitative Reverse Transcription Polymerase Chain Reaction of the Oncotype DX Test: An Independent Quality Assurance Study.
Dabbs DJ, Klein ME, Mohsin SK, et al. J Clin Oncol. 2011 Oct 11.

Common breast cancer gene test may be flawed, study says, US News, November 4

'Preemptive' statin-myopathy gene test offered to patients, Medscape, November 3

Delivering a Pharmacogenetic Service: Is There a Role for Genetic Counselors?
Callard A, et al. J Genet Couns 2011 Nov

Ethics for the pediatrician: genetic testing and newborn screening
Gonzales JL Pediatr Rev 2011 Nov;32(11):490-3

Interpretation of genetic testing for lynch syndrome in patients with putative familial colorectal cancer
Rybak C & Hall MJ J Natl Compr Canc Netw 2011 Nov;9(11):1311-20

Practical considerations to guide development of access controls and decision support for genetic information in electronic medical records
Darcy DC, et al. BMC Health Serv Res 2011 Nov;11(1):294

2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy
Gersh B, Maron B, Bonow R, et al. J Am Coll Cardiol 2011 Nov 8

New guidelines issued for genetic heart disease, US News and World Report, November 8

Age-related macular degeneration: current treatment and future options
Moutray T. Ther Adv Chronic Dis. 2011;2(5):325-331

Age-related macular degeneration, Medcape, November 7

Pharmacogenomics of Clopidogrel: Clinical Implications, Medscape, November 7

DNA Theft: Your Genetic Information at Risk
Joh EE.  Nat Rev Genet. 2011 Oct 25.

Congressional Leaders Expect to Give Personalized Medicine Act Another Shot, GEN, November 9

Gene patent upheld by British Supreme Court, PHG Foundation, November 8

Guidelines for establishing locus specific databases
Vihinen M, et al. Hum Mutat 2011 Nov

Public Perspectives About Pharmacogenetic Testing and Managing Ancillary Findings
Haga SB, et al. Genet Test Mol Biomarkers 2011 Nov

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis
March H, Rust A, Wright N, et al. Nature Genetics, 2011;

Colorectal cancer: Jumping gene named sleeping beauty plays vital role in investigating cancer pathway, Science Daily, November 6

Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1.
Bown MJ, Jones GT, Harrison SC, et al. Am J Hum Genet. 2011 Nov 3.

New methods to treat aneurysms may result from gene discovery, Medical News Today, November 6

An X-chromosome-wide association study in autism families identifies TBL1X as a novel autism spectrum disorder candidate gene in males.
Chung RH, Ma D, Wang K, et al. Mol Autism. 2011 Nov 4;2(1):18.

X marks the spot -- TBL1X gene involved in autism spectrum disorder, EurekAlert, November 3

Evaluation of pooling strategies for acute HIV-1 infection screening using nucleic acid amplification testing
Sullivan TJ, Patel P, Hutchinson A, Ethridge SF, Parker MM. J Clin Microbiol. 2011 Oct;49(10):3667-8.

North American West Nile virus genotype isolates demonstrate differential replicative capacities in response to temperature
Andrade CC, Maharaj PD, Reisen WK, Brault AC. J Gen Virol. 2011 Nov;92(Pt 11):2523-33.

Tuberculosis Genotyping Information Management System: enhancing tuberculosis surveillance in the United States
Ghosh S, Moonan P, Cowan L, Grant J, Kammerer S, Navin T. Infect Genet Evol. 2011 Oct 25.

What questions should newborn screening long-term follow-up be able to answer? A statement of the US Secretary for Health and Human Services' Advisory Committee on Heritable Disorders in Newborns and Children
Hinton CF, Feuchtbaum L, Kus CA, Kemper AR, Berry SA, Levy-Fisch J, Luedtke J, Kaye C, Boyle CA. Genet Med. 2011 Oct;13(10):861-865.

Interview: Personal account of the discovery of a new disease using next-generation sequencing
Lyon G. Future Medicine November 2011, Vol. 12, No. 11, Pages 1519-1523

Hit reset on cancer screening: 'Tests not perfect', USA Today, November 7

International project to examine epilepsy genomics, PHG Foundation, November 7

Perspectives on translational science, PHG Foundation, November 4

Gene cure in sight for eye disorders, PHG Foundation, November 3

Genomics giant joins fight to beat autism, PHG Foundation, November 3