Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update offers links to genomics news and publications relevant to public health. The Update highlights family health history and genomic tests, along with relevant data, policy, and legislation. Please send your comments to: firstname.lastname@example.org.
Thursday, November 3, 2011 Volume 27 Number 18
- Diabetes Awareness Month:
- New Publication: Implementing screening for Lynch syndrome among patients with newly diagnosed colorectal cancer: Summary of a public health/clinical collaborative meeting. Bellcross CA, et al.. Genet Med. 2011 Oct 21.
- Call for Pharmacogenomic Tests Submissions - PLoS Currents Evidence on Genomic Tests
PLoS Currents Evidence on Genomic Tests is an open-access online publication that accepts brief evidence summaries based on rapid review of available information on the analytic validity, clinical validity, and clinical utility of genomic tests. A template that illustrates the structure of the articles can be found here. Summaries published in PLoS Currents Evidence on Genomic Tests are permanently archived in PubMedCentral and searchable through PubMed. Potential authors are encouraged to look at the FDA Table of Pharmacogenomic Biomarkers in Drug Labels for ideas on topics to consider. We look forward to receiving your pharmacogenomics article submissions!
- The EGAPP Working Group (EWG) will be adding at least 3 new members in 2011. Nominations for membership on the EWG are accepted on a continuous basis.
Pharmacogenomics of 6-Mercaptopurine: Clinical implications, Medscape, November 1 [by free subscription only]
From gene testing to the bedside: workshop focuses on future strategies.
Goozner M. J Natl Cancer Inst. 2011 Aug 3;103(15):1150-1.
From gene testing to the bedside, Medscape, October 31 [by free subscription only]
Gene expression reveals metastatic risk in Uveal melanoma, Medscape, October 31 [by free subscription only]
Proposed NIH genetic testing registry lacks clarity, understates costs, EurekAlert, October 27
When breast cancer tests get it wrong, CNN Health, October 27
Breast Cancer Risk for Noncarriers of Family-Specific BRCA1 and BRCA2 Mutations: Findings From the Breast Cancer Family Registry.
Kurian AW, Gong GD, John EM, et al. J Clin Oncol. 2011 Oct 31
Women who don't have BRCA mutation but have relatives who do do not face an increased risk of breast cancer, Medical News Today, November 1
Genomic Education Resources for Nursing Faculty
Tonkin E, et al. J Nurs Scholarsh 2011 Oct
Genomics in nursing and midwifery, PHG Foundation, October 31
Ethical aspects of the expansion of neonatal screening programme due to technological advances
Elliman D Clin Chem Lab Med 2011 Oct
Genomics really gets personal: How exome and whole genome sequencing challenge the ethical framework of human genetics research
Tabor HK, et al. Am J Med Genet A 2011 Oct
Abbott's genetic test for acute myeloid leukemia prognosis cleared by FDA, Medical News Today, October 28
Do all women need genetic testing before pregnancy? Time Healthland, October 27
Can genetic risk information for age-related macular degeneration influence motivation to stop smoking? A pilot study
Rennie CA, et al. Eye (Lond) 2011 Oct
Genomics and the Multifactorial Nature of Human Autoimmune Disease
Cho JH, Gregersen PK. N Engl J Med. 2011 Oct 27;365(17):1612-23.
Associations with early-life socio-economic position in adult DNA methylation
Borghol N, Suderman M, McArdle W, et al. Int. J. Epidemiol. (2011) Oct 20
How your childhood might change your genes, PHG Foundation, October 28
Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
Kilpeläinen T, Qi L, Brage S, et al. PLoS Med 2011 8(11): e1001116.
Physical activity reduces the effect of the 'obesity gene', EurekAlert, November 1
High incidence of NLRP3 somatic mosaicism in chronic infantile neurological cutaneous and articular syndrome patients: The results of an international multicenter collaborative study.
Tanaka N, Izawa K, Saito MK, et al. Arthritis Rheum. 2011 Jun 23.
NIH scientists discover link among spectrum of childhood diseases, NIH News, October 31
Temporal Dynamics and Genetic Control of Transcription in Human Prefontal Cortex
Colantuoni C, Lipska BK, Ye T, et al. Nature. 2011 Oct 26;478(7370):519-23.
Scientists chart gene expression in the brain across lifespan, Science Daily, October 28
Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
Burn J, Gerdes A, Macrae F, et al. Lancet 2011 Oct 28
Aspirin cuts colorectal cancer risk in Lynch syndrome patients, ABC News, October 27
People with genetic risk of cancer reduce chances with aspirin, but not recommended for most, Washington Post, October 27
The eph-receptor a7 is a soluble tumor suppressor for follicular lymphoma.
Oricchio E, Nanjangud G, Wolfe AL, et al. Cell. 2011 Oct 28;147(3):554-64.
From genomic data to new cancer drug, EurekAlert, October 27
CDC authors are indicated in bold
Comparison of real-time PCR and a microimmunofluorescence serological assay for detection of Chlamydophila pneumoniae infection in an outbreak investigation
Benitez AJ, Thurman KA, Diaz MH, Conklin L, Kendig NE, Winchell JM. J Clin Microbiol. 2011 Oct 26.
Gene expression analysis in the thalamus and cerebrum of horses experimentally infected with West Nile virus
Bourgeois MA, Denslow ND, Seino KS, Barber DS, Long MT. PLoS One. 2011 ;6(10):e24371.
Hepatitis B outbreak associated with a hematology-oncology office practice in New Jersey, 2009
Greeley RD, Semple S, Thompson ND, High P, Rudowski E, Handschur E, Xia GL, Ganova-Raeva L, Crawford J, Robertson C, Tan C, Montana B. Am J Infect Control. 2011 Oct;39(8):663-70.
The iron-responsive regulator Irr is required for wild-type expression of the gene encoding the heme transporter BhuA in Brucella abortus 2308
Anderson ES, Paulley JT, Martinson DA, Gaines JM, Steele KH, Roop RM. J Bacteriol. 2011 Oct;193(19):5359-64.
Phylogeography and molecular epidemiology of Yersinia pestis in Madagascar
Vogler AJ, Chan F, Wagner DM, Roumagnac P, Lee J, Nera R, Eppinger M, Ravel J, Rahalison L, Rasoamanana BW, Beckstrom-Sternberg SM, Achtman M, Chanteau S, Keim P. PLoS Negl Trop Dis. 2011 Sep;5(9):e1319.
ALFRED: an allele frequency resource for research and teaching
Rajeevan H, et al. Nucleic Acids Res 2011 Oct
Detours on the Road to Personalized Medicine
Fiore L, D’Avolio L. JAMA 2011;306(17):1914-1915
BioNOT: A searchable database of biomedical negated sentences.
Agarwal S, Yu H, Kohane I. BMC Bioinformatics. 2011 Oct 27;12(1):420.
Search tool accentuates the negative, eliminates the positive, Science Insider, November 2
'Wrongful life' - the children who sue for being born, Bio News, October 31
Field performance of engineered male mosquitoes
Harris AF, Nimmo D, McKemey AR, et al. Nat Biotechnol. 2011 Oct 30.
Concerns are raised about genetically engineered mosquitoes, The New York Times, October 30
Google strikes deal to preserve DNA data online, Montreal Gazette, October 27
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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