 For information on human genome epidemiology, please visit the HuGE Navigator |
 For information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base |
Genomics & Health Impact Update
The Office of Public Health Genomics (OPHG) provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation. We hope the update is informative to practitioners, policy makers, consumers, and researchers. Please send your comments to: genetics@cdc.gov.
Thursday, May 5, 2011 Volume 26 Number 18
Spotlight
New Genomics and Health Impact Blog
In the Genomics and Health Impact blog, we will offer comments from a public health perspective on genomic research and programs conducted by CDC and other institutions around the world. We will not provide individual medical advice or endorse specific commercial products. We encourage respectful comments and dialogue.
Announcement
CancerGEM KB
CDC Office of Public Health Genomics in collaboration with NCI Division of Cancer Control and Population Sciences has launched the CancerGEM KB. It is an online resource for researchers, public health professionals, policy makers, and health care providers interested in the use of genomic information in cancer care and prevention. CancerGEM KB provides objective synthesis and timely dissemination of information on cancer human genome epidemiology (genetic associations, gene-environment interactions and gene prevalence information) and aggregated evidence on cancer genomic tests in transition to clinical and public health practice. CancerGEM KB also provides information on genomic tests through PLoS Currents: Evidence on Genomic Tests, an open-access journal for systematic reviews and structured short summaries of evidence for the validity and utility of genetic tests.
Topics
Genomic Tests
Diagnostic Yield of Genetic Testing in Children Diagnosed With Autism Spectrum Disorders at a Regional Referral Center
Roesser J Clin Pediatr (Phila) 2011 Apr
American Society of Clinical Oncology Provisional Clinical Opinion: Epidermal Growth Factor Receptor (EGFR) Mutation Testing for Patients With Advanced Non-Small-Cell Lung Cancer Considering First-Line EGFR Tyrosine Kinase Inhibitor Therapy.
Keedy VL, Temin S, Somerfield MR, et al. J Clin Oncol. 2011 Apr 11.
ASCO recommends EGFR Testing for NSCLC, but for which patients, Medscape Today, April 28 [by free subscription only]
For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base.
Family Health History
Risk Prediction of Complex Diseases from Family History and Known Susceptibility Loci, with Applications for Cancer Screening
So HC, et al. Am J Hum Genet 2011 Apr
Practice and Programs
Cystic fibrosis newborn screening does not delay the identification of cystic fibrosis in children with negative results
Maclean JE, et al. J Cyst Fibros 2011 Apr
Patients-in-waiting: Living between sickness and health in the genomics era.
Timmermans S, Buchbinder M. J Health Soc Behav. 2010 Dec;51(4):408-23.
Pros, cons of newborn genetic screening, Jewish Journal, May 3
Use and Evaluation of an Individually Tailored Website for Counselees Prior to Breast Cancer Genetic Counseling
Albada A, et al. J Cancer Educ 2011 May
Policy and Legislation
Feedback of individual genetic results to research participants: in favor of a qualified disclosure policy
Bredenoord AL, et al. Hum Mutat 2011 Apr
Lab group to ask congress for statutory changes to keep LDTs under CLIA, Genome Web, May 4 [by free subscription only]
In final report, SACGHS addresses genetics education, training, Genome Web, April 27 [by free subscription only]
10 Years After the Human Genome Project, AACC Clinical Laboratory News
Personalized Perspectives, Genome Web, May [by free subscription only]
Data and Statistics
A cost-effectiveness analysis of prophylactic surgery versus gynecologic surveillance for women from hereditary non-polyposis colorectal cancer (HNPCC) Families
Yang KY, et al. Fam Cancer 2011 May
BRCA1 mutations do not increase prostate cancer risk: Results from a meta-analysis including new data.
Fachal L, Gómez-Caamaño A, Celeiro-Muñoz C, et al. Prostate. 2011 Apr 25.
Testing Women With Endometrial Cancer to Detect Lynch Syndrome
Kwon JS, et al. J Clin Oncol 2011 May
Best way to screen for Lynch syndrome in women with endometrial cancer identified, Cure Today, May 2
A User's Guide to the Encyclopedia of DNA Elements (ENCODE).
The ENCODE Project Consortium. PLoS Biol. 2011 Apr;9(4):e1001046.
Progress and challenges for the Encyclopedia of DNA elements, PHG Foundation, May 1
For this week's human genome epidemiology articles, please visit the HuGE Literature Finder in the HuGE Navigator.
CDC-Authored Genomics Publications
CDC authors are indicated in boldApplied genomics: Data mining reveals species-specific malaria diagnostic targets more sensitive than 18S rRNA
Demas A, Oberstaller J, Debarry J, Lucchi NW, Srinivasamoorthy G, Sumari D, Kabanywanyi AM, Villegas L, Escalante AA, Kachur SP, Barnwell JW, Peterson DS, Udhayakumar V, Kissinger JC. J Clin Microbiol. 2011 Apr 27.
Implementation of the first worldwide quality assurance program for cystic fibrosis multiple mutation detection in population-based screening
Earley MC, Laxova A, Farrell PM, Driscoll-Dunn R, Cordovado S, Mogayzel PJ, Konstan MW, Hannon WH. Clin Chim Acta. 2011 Apr 14.
Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice
Erdely A, Hulderman T, Salmen-Muniz R, Liston A, Zeidler-Erdely PC, Chen BT, Stone S, Frazer DG, Antonini JM, Simeonova PP. Toxicol Lett. 2011 Apr 14.
Live attenuated rabies virus co-infected with street rabies virus protects animals against rabies
Wu X, Franka R, Henderson H, Rupprecht CE. Vaccine. 2011 Apr 20.
Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis
Li JZ, Paredes R, Ribaudo HJ, Svarovskaia ES, Metzner KJ, Kozal MJ, Hullsiek KH, Balduin M, Jakobsen MR, Geretti AM, Thiebaut R, Ostergaard L, Masquelier B, Johnson JA, Miller MD, Kuritzkes DR. JAMA. 2011 Apr 6;305(13):1327-35.
Temporal variations in the hepatitis C virus intra-host population during chronic infection
Ramachandran S, Campo DS, Dimitrova ZE, Xia GL, Purdy MA, Khudyakov YE. J Virol. 2011 Apr 27.
View previous CDC-authored publications
Events and Training
Personalized Medicine: Why the Future Will Work and the Present Doesn't
Public Workshop - Study Methodologies for Diagnostics in the Postmarket Setting
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