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Genomics & Health Impact Update

The Office of Public Health Genomics (OPHG) provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation. We hope the update is informative  to practitioners, policy makers, consumers, and researchers. Please send your comments to: genetics@cdc.gov.


Thursday, May 5, 2011       Volume 26   Number 18


Spotlight

Genomics and Health Impact Blog

New Genomics and Health Impact Blog

In the Genomics and Health Impact blog, we will offer comments from a public health perspective on genomic research and programs conducted by CDC and other institutions around the world.  We will not provide individual medical advice or endorse specific commercial products. We encourage respectful comments and dialogue.

 



Announcement


CancerGEM KB
CDC Office of Public Health Genomics in collaboration with NCI Division of Cancer Control and Population Sciences has launched the CancerGEM KB.  It is an online resource for researchers, public health professionals, policy makers, and health care providers interested in the use of genomic information in cancer care and prevention. CancerGEM KB provides objective synthesis and timely dissemination of information on cancer human genome epidemiology (genetic associations, gene-environment interactions and gene prevalence information) and aggregated evidence on cancer genomic tests in transition to clinical and public health practice. CancerGEM KB also provides information on genomic tests through PLoS Currents: Evidence on Genomic Tests, an open-access journal for systematic reviews and structured short summaries of evidence for the validity and utility of genetic tests.



Topics


Genomic Tests

ASCO recommends EGFR Testing for NSCLC, but for which patients, Medscape Today, April 28 [by free subscription only]

For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base.

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Family Health History

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Practice and Programs

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Policy and Legislation

Lab group to ask congress for statutory changes to keep LDTs under CLIA, Genome Web, May 4 [by free subscription only]

In final report, SACGHS addresses genetics education, training, Genome Web, April 27 [by free subscription only]

10 Years After the Human Genome Project, AACC Clinical Laboratory News

Personalized Perspectives, Genome Web, May [by free subscription only]

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Data and Statistics

A User's Guide to the Encyclopedia of DNA Elements (ENCODE).
The ENCODE Project Consortium. PLoS Biol. 2011 Apr;9(4):e1001046.

For this week's human genome epidemiology articles, please visit the HuGE Literature Finder in the HuGE Navigator.

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CDC-Authored Genomics Publications

CDC authors are indicated in bold

Applied genomics: Data mining reveals species-specific malaria diagnostic targets more sensitive than 18S rRNA
Demas A, Oberstaller J, Debarry J, Lucchi NW, Srinivasamoorthy G, Sumari D, Kabanywanyi AM, Villegas L, Escalante AA, Kachur SP, Barnwell JW, Peterson DS, Udhayakumar V, Kissinger JC. J Clin Microbiol. 2011 Apr 27.

Implementation of the first worldwide quality assurance program for cystic fibrosis multiple mutation detection in population-based screening
Earley MC, Laxova A, Farrell PM, Driscoll-Dunn R, Cordovado S, Mogayzel PJ, Konstan MW, Hannon WH. Clin Chim Acta. 2011 Apr 14.

Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice
Erdely A, Hulderman T, Salmen-Muniz R, Liston A, Zeidler-Erdely PC, Chen BT, Stone S, Frazer DG, Antonini JM, Simeonova PP. Toxicol Lett. 2011 Apr 14.

Live attenuated rabies virus co-infected with street rabies virus protects animals against rabies
Wu X, Franka R, Henderson H, Rupprecht CE. Vaccine. 2011 Apr 20.

Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis
Li JZ, Paredes R, Ribaudo HJ, Svarovskaia ES, Metzner KJ, Kozal MJ, Hullsiek KH, Balduin M, Jakobsen MR, Geretti AM, Thiebaut R, Ostergaard L, Masquelier B, Johnson JA, Miller MD, Kuritzkes DR. JAMA. 2011 Apr 6;305(13):1327-35.

Temporal variations in the hepatitis C virus intra-host population during chronic infection
Ramachandran S, Campo DS, Dimitrova ZE, Xia GL, Purdy MA, Khudyakov YE. J Virol. 2011 Apr 27.

View previous CDC-authored publications

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Events and Training

Personalized Medicine: Why the Future Will Work and the Present Doesn't

Public Workshop - Study Methodologies for Diagnostics in the Postmarket Setting

AACC Annual Meeting 2011

Access other events

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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.

 

 

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  • Additional information for Public Health Genomics is available on our contact page.

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