Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, March 17, 2011       Volume 26   Number 11

Spotlight

Strengthening the Reporting of Genetic RIsk Prediction Studies (GRIPS)

A multidisciplinary panel sponsored by CDC and the Human Genome Epidemiology Network (HuGENet™) has published recommendations for strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS). The statement and elaboration papers are published simultaneously in multiple journals today. Read more.

 

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Announcements

• New publication of interest, Current priorities for public health practice in addressing the role of human genomics in improving population health, published in American Journal of Preventive Medicine, March 2011. Authors: Khoury MJ, Bowen MS, Burke W, Coates RJ, Dowling NJ, Evans JP, Reyes M, St. Pierre J.
• Starting March 24 2011, the Genomics & Health Weekly Update will have a new name – Genomics & Health Impact Update –and a new mission. The update will focus on genomic information that has more direct  impact on policy and practice. We hope the new Genomics & Health Impact Update will be informative and useful to practitioners, policy makers, and consumers, and researchers. We welcome your comments. Learn more.
• Special report on the Genome-based Knowledge Management in Cycles model: a complex adaptive systems framework for implementation of genomic applications published in Personalized Medicine by members of the GAPPNet™ Knowledge Synthesis & Dissemination Working Group in March 2011. Authors: Arar N, Knight SJ, Modell SM, Issa AM for the GAPPNet Inaugural Knowledge Synthesis and Dissemination Working Group.

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer

New genetic insights into bowel cancer, PHG Foundation, March 16

Tamoxifen found to prevent breast cancer deaths in at-risk women, My Health News Daily, March 14

Patient turns genetic detective, BBC News, March 13

Prostate cancer tests improving with new technology, Today Health, March 13

A blood test for lung cancer, Science Daily, March 12

Cardiovascular Disease

Found: the rouge genes behind heart disease, IOL, March 14

Chronic Disease

Wellcome Trust GWAS yields liver cirrhosis risk loci, Genome Web, March 14 [by free subscription only]

Ethical, Legal, and Social Issues (ELSI)

Key house members comment on impact of genetic tests on health care quality and cost in the Hill policy briefing, Atlanta Business Chronicle, March 16

Rights to personal genome testing, PHG Foundation, March 15

Action needed on genetic privacy pact, WBJournal, March 14

NCCN panel calls for higher standards, better ways of translating molecular genetics into clinical practice, Insurancenewsnet, March 14

DTC genomics firms say they want to comply with FDA regs but maintain direct access, Genome Web, March 11 [by free subscription only]

AMA calls for regulation of consumer genetic tests, amednews,com, March 10

Aspects of total genome sequencing, Research in Germany, March 10

Family History

You Docs: Family health history more important than any DNA testing, Oregon Live, March 16

Collecting a family medical history, South Washington County Bulletin, March 15

Health history Monday, John Hopkins School of Public Health, March 14

Family can predict ills, The Arizona Republic, March 13

Genetic Testing

Genetic mapping raises hope for cures, Canada.com, March 16

Some genetic tests should be "prescription only", New Scientist, March 15

Majority of Americans support government involvement in distribution of genetic test, News-Medical.Net, March 11

Neurologic Conditions

Gene therapy reverses symptoms of Parkinson's disease, EurekAlert, March 17

Pharmacogenomics

Pharmacogenomics becomes standard in over 50 hospitals throughout Taiwan through use of new genetic screening kit, Medical News Today, March 13

Other

Fragile X researcher honored by March of Dimes, EurekAlert, March 16

New reporting guidelines for genetic risk prediction studies: GRIPS Statement, EurekAlert, March 15

Future of genome research: More therapies, scarcer funding, U.S. Medicine, March 14

Researchers discover new gene for Sensenbrenner syndrome, News-Medical,Net, March 14

Scientists need new metaphor for human genome, The National, March 13

It's all in the genes, Savannah Now, March 11

New gene sites affecting nonalcoholic fatty liver disease (NAFLD) discovered, Medical News Today, March 11

Genetics is "Top of the Pops" in science research, News Daily, March 10

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Genomics in the Scientific Literature

Cancer

How useful is it clinically to analyse the K-ras mutational status for the diagnosis of exocrine pancreatic cancer? A systematic review and meta-analysis
Parker LA, et al.
Eur J Clin Invest 2011 Mar

Outcome of risk-reducing salpingo-oophorectomy in BRCA carriers and women of unknown mutation status
Manchanda R, et al.
BJOG 2011 Mar

Value of Mismatch Repair, KRAS, and BRAF Mutations in Predicting Recurrence and Benefits From Chemotherapy in Colorectal Cancer
Hutchins G, et al.
J Clin Oncol 2011 Mar

Chronic Disease

Autosomal dominant polycystic kidney disease: genetics, mutations and microRNAs
Tan YC, et al.
Biochim Biophys Acta 2011 Mar

The quest for genetic risk factors for Crohn's disease in the post-GWAS era
Fransen K, et al.
Genome Med 2011 Feb;3(2):13

Diabetes

FTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life: A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies
Hertel JK, et al.
Diabetes 2011 Mar

Epigenomics

Diet Induced Epigenetic Changes and their implications for Health
McKay JA & Mathers JC
Acta Physiol (Oxf) 2011 Mar

Epigenetics of asthma
Durham AL, et al.
Biochim Biophys Acta 2011 Mar

Translational Application of Epigenetic Alterations: Ovarian Cancer as a Model
Maradeo ME & Cairns P
FEBS Lett 2011 Mar

Ethical, Legal, and Social Issues (ELSI)

ACCE, Pharmacogenomics, and Stopping Clinical Trials: Time to Extend the CONSORT  Statement?
Ozdemir V, et al.
Am J Bioeth 2011 Mar;11(3):11-3

Ethical Considerations for Genetic Testing, Infertility, and Balancing Maternal-Fetal Needs
Callister LC
MCN Am J Matern Child Nurs 2011 Mar

Not so simple: a quasi-experimental study of how researchers adjudicate genetic research results
Hayeems RZ, et al.
Eur J Hum Genet 2011 Mar

Family History

Familial breast cancer: is it time to move from a reactive to a proactive role?
Harris H, et al.
Fam Cancer 2011 Mar

Family history of cancer and the risk of laryngeal cancer: A case-control study from Italy and Switzerland
Garavello W, et al.
Int J Cancer 2011 Mar

How much colonoscopy screening should be recommended to individuals with various degrees of family history of colorectal cancer?
Wilschut JA, et al.
Cancer 2011 Mar

Lifestyle Behaviors in Black and White Women With a Family History of Breast Cancer
Spector D, et al.
Prev Med 2011 Mar

Six sequence variants on chromosome 9p21.3 are associated with a positive family  history of myocardial infarction: a multicenter registry
Scheffold T, et al.
BMC Cardiovasc Disord 2011 Mar;11(1):9

The Asia-Pacific Colorectal Screening score: a validated tool that stratifies risk for colorectal advanced neoplasia in asymptomatic Asian subjects
Yeoh KG, et al.
Gut 2011 Mar

Genetic Testing

Community Corner: Opening the Pandora's box of prenatal genetic testing
Nat Med 2011 Mar;17(3):250-1

Genetic testing and youth sports
Brooks MA & Tarini BA
JAMA 2011 Mar;305(10):1033-4

The educational role of External Quality Assessment in genetic testing: a 7-year  experience of The European Molecular Genetics Quality Network (EMQN) in Lynch syndrome
Qiu J, et al.
Hum Mutat 2011 Mar

The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing
Pharoah PD, et al.
Clin Cancer Res 2011 Mar

Infectious Disease

Association of Host Genetic Risk Factors With the Course of Cytomegalovirus Retinitis in Patients Infected With Human Immunodeficiency Virus
Sezgin E, et al.
Am J Ophthalmol 2011 Mar

Mental Health

Knowledge and Attitudes about Personalized Mental Health Genomics: Narratives from Individuals Coping with Serious Mental Illness
Potokar DN, et al.
Community Ment Health J 2011 Mar

Neurologic Conditions

Psychotropic Drug Effects on Gene Transcriptomics Relevant to Alzheimer Disease
Lauterbach EC
Alzheimer Dis Assoc Disord 2011 Mar

Pharmacogenomics

Pharmacogenomic testing in a tertiary care outpatient psychosomatic medicine practice
Rundell JR, et al.
Psychosomatics 2011 Mar-2011 Apr;52(2):141-6

Pharmacogenomics of cardiovascular drugs and adverse effects in paediatrics
Visscher H, et al.
J Cardiovasc Pharmacol 2011 Feb

Smoking, Tobacco and Alcohol

Association of the Nicotine Metabolite Ratio and CHRNA5/CHRNA3 Polymorphisms With Smoking Rate Among Treatment-Seeking Smokers
Falcone M, et al.
Nicotine Tob Res 2011 Mar

Other

Strengthening the reporting of genetic risk prediction studies: the GRIPS statement
Janssens AC, et al.
Eur J Hum Genet 2011 Mar

Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration
Janssens AC, et al.
Eur J Hum Genet 2011 Mar

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

GAPP

For the most recent information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base.

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