Genomics & Health Weekly Update
This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.
Thursday, March 17, 2011 Volume 26 Number 11
Strengthening the Reporting of Genetic RIsk Prediction Studies (GRIPS)
A multidisciplinary panel sponsored by CDC and the Human Genome Epidemiology Network (HuGENet™) has published recommendations for strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS). The statement and elaboration papers are published simultaneously in multiple journals today. Read more.
- New publication of interest, Current priorities for public health practice in addressing the role of human genomics in improving population health, published in American Journal of Preventive Medicine, March 2011. Authors: Khoury MJ, Bowen MS, Burke W, Coates RJ, Dowling NJ, Evans JP, Reyes M, St. Pierre J.
- Starting March 24 2011, the Genomics & Health Weekly Update will have a new name – Genomics & Health Impact Update –and a new mission. The update will focus on genomic information that has more direct impact on policy and practice. We hope the new Genomics & Health Impact Update will be informative and useful to practitioners, policy makers, and consumers, and researchers. We welcome your comments. Learn more.
- Special report on the Genome-based Knowledge Management in Cycles model: a complex adaptive systems framework for implementation of genomic applications published in Personalized Medicine by members of the GAPPNet™ Knowledge Synthesis & Dissemination Working Group in March 2011. Authors: Arar N, Knight SJ, Modell SM, Issa AM for the GAPPNet Inaugural Knowledge Synthesis and Dissemination Working Group.
- The following are headlines from on-line news articles published during the past week.
- The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
- Free registration required for some articles.
New genetic insights into bowel cancer, PHG Foundation, March 16
Tamoxifen found to prevent breast cancer deaths in at-risk women, My Health News Daily, March 14
Patient turns genetic detective, BBC News, March 13
Prostate cancer tests improving with new technology, Today Health, March 13
A blood test for lung cancer, Science Daily, March 12
Found: the rouge genes behind heart disease, IOL, March 14
Wellcome Trust GWAS yields liver cirrhosis risk loci, Genome Web, March 14 [by free subscription only]
Key house members comment on impact of genetic tests on health care quality and cost in the Hill policy briefing, Atlanta Business Chronicle, March 16
Rights to personal genome testing, PHG Foundation, March 15
Action needed on genetic privacy pact, WBJournal, March 14
NCCN panel calls for higher standards, better ways of translating molecular genetics into clinical practice, Insurancenewsnet, March 14
DTC genomics firms say they want to comply with FDA regs but maintain direct access, Genome Web, March 11 [by free subscription only]
AMA calls for regulation of consumer genetic tests, amednews,com, March 10
Aspects of total genome sequencing, Research in Germany, March 10
You Docs: Family health history more important than any DNA testing, Oregon Live, March 16
Collecting a family medical history, South Washington County Bulletin, March 15
Health history Monday, John Hopkins School of Public Health, March 14
Family can predict ills, The Arizona Republic, March 13
Genetic mapping raises hope for cures, Canada.com, March 16
Some genetic tests should be "prescription only", New Scientist, March 15
Majority of Americans support government involvement in distribution of genetic test, News-Medical.Net, March 11
Gene therapy reverses symptoms of Parkinson's disease, EurekAlert, March 17
Pharmacogenomics becomes standard in over 50 hospitals throughout Taiwan through use of new genetic screening kit, Medical News Today, March 13
Fragile X researcher honored by March of Dimes, EurekAlert, March 16
New reporting guidelines for genetic risk prediction studies: GRIPS Statement, EurekAlert, March 15
Future of genome research: More therapies, scarcer funding, U.S. Medicine, March 14
Researchers discover new gene for Sensenbrenner syndrome, News-Medical,Net, March 14
Scientists need new metaphor for human genome, The National, March 13
It's all in the genes, Savannah Now, March 11
New gene sites affecting nonalcoholic fatty liver disease (NAFLD) discovered, Medical News Today, March 11
Genetics is "Top of the Pops" in science research, News Daily, March 10
How useful is it clinically to analyse the K-ras mutational status for the diagnosis of exocrine pancreatic cancer? A systematic review and meta-analysis
Parker LA, et al.
Eur J Clin Invest 2011 Mar
Outcome of risk-reducing salpingo-oophorectomy in BRCA carriers and women of unknown mutation status
Manchanda R, et al.
BJOG 2011 Mar
Value of Mismatch Repair, KRAS, and BRAF Mutations in Predicting Recurrence and Benefits From Chemotherapy in Colorectal Cancer
Hutchins G, et al.
J Clin Oncol 2011 Mar
Autosomal dominant polycystic kidney disease: genetics, mutations and microRNAs
Tan YC, et al.
Biochim Biophys Acta 2011 Mar
The quest for genetic risk factors for Crohn's disease in the post-GWAS era
Fransen K, et al.
Genome Med 2011 Feb;3(2):13
FTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life: A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies
Hertel JK, et al.
Diabetes 2011 Mar
Diet Induced Epigenetic Changes and their implications for Health
McKay JA & Mathers JC
Acta Physiol (Oxf) 2011 Mar
Epigenetics of asthma
Durham AL, et al.
Biochim Biophys Acta 2011 Mar
Translational Application of Epigenetic Alterations: Ovarian Cancer as a Model
Maradeo ME & Cairns P
FEBS Lett 2011 Mar
ACCE, Pharmacogenomics, and Stopping Clinical Trials: Time to Extend the CONSORT Statement?
Ozdemir V, et al.
Am J Bioeth 2011 Mar;11(3):11-3
Ethical Considerations for Genetic Testing, Infertility, and Balancing Maternal-Fetal Needs
MCN Am J Matern Child Nurs 2011 Mar
Not so simple: a quasi-experimental study of how researchers adjudicate genetic research results
Hayeems RZ, et al.
Eur J Hum Genet 2011 Mar
Familial breast cancer: is it time to move from a reactive to a proactive role?
Harris H, et al.
Fam Cancer 2011 Mar
Family history of cancer and the risk of laryngeal cancer: A case-control study from Italy and Switzerland
Garavello W, et al.
Int J Cancer 2011 Mar
How much colonoscopy screening should be recommended to individuals with various degrees of family history of colorectal cancer?
Wilschut JA, et al.
Cancer 2011 Mar
Lifestyle Behaviors in Black and White Women With a Family History of Breast Cancer
Spector D, et al.
Prev Med 2011 Mar
Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry
Scheffold T, et al.
BMC Cardiovasc Disord 2011 Mar;11(1):9
Community Corner: Opening the Pandora's box of prenatal genetic testing
Nat Med 2011 Mar;17(3):250-1
Genetic testing and youth sports
Brooks MA & Tarini BA
JAMA 2011 Mar;305(10):1033-4
The educational role of External Quality Assessment in genetic testing: a 7-year experience of The European Molecular Genetics Quality Network (EMQN) in Lynch syndrome
Qiu J, et al.
Hum Mutat 2011 Mar
The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing
Pharoah PD, et al.
Clin Cancer Res 2011 Mar
Association of Host Genetic Risk Factors With the Course of Cytomegalovirus Retinitis in Patients Infected With Human Immunodeficiency Virus
Sezgin E, et al.
Am J Ophthalmol 2011 Mar
Knowledge and Attitudes about Personalized Mental Health Genomics: Narratives from Individuals Coping with Serious Mental Illness
Potokar DN, et al.
Community Ment Health J 2011 Mar
Psychotropic Drug Effects on Gene Transcriptomics Relevant to Alzheimer Disease
Alzheimer Dis Assoc Disord 2011 Mar
Pharmacogenomic testing in a tertiary care outpatient psychosomatic medicine practice
Rundell JR, et al.
Psychosomatics 2011 Mar-2011 Apr;52(2):141-6
Pharmacogenomics of cardiovascular drugs and adverse effects in paediatrics
Visscher H, et al.
J Cardiovasc Pharmacol 2011 Feb
Association of the Nicotine Metabolite Ratio and CHRNA5/CHRNA3 Polymorphisms With Smoking Rate Among Treatment-Seeking Smokers
Falcone M, et al.
Nicotine Tob Res 2011 Mar
Strengthening the reporting of genetic risk prediction studies: the GRIPS statement
Janssens AC, et al.
Eur J Hum Genet 2011 Mar
Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration
Janssens AC, et al.
Eur J Hum Genet 2011 Mar
For this week's human genome epidemiology articles, please visit the HuGE Navigator.
For the most recent information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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